Article
Endocrinology & Metabolism
Carolina Chaves, Eveline Bruinstroop, Samuel Refetoff, Paul Yen, Joao Anselmo
Summary: The study found that mutations in the THRB gene causing resistance to thyroid hormone beta can lead to increased hepatic steatosis, particularly affecting intrahepatic TR beta signaling, independent of factors like age and obesity. This highlights the importance of thyroid hormone in liver lipid metabolism and provides a rationale for the development of TR beta-selective thyromimetics.
Article
Endocrinology & Metabolism
Giuseppe Petito, Federica Cioffi, Elena Silvestri, Rita De Matteis, Davide Lattanzi, Pieter de Lange, Assunta Lombardi, Maria Moreno, Fernando Goglia, Antonia Lanni, Rosalba Senese
Summary: This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rossella Cannarella, Marco Musmeci, Vincenzo Garofalo, Tiziana A. Timpanaro, Guido Leone, Manuela Caruso, Paolo E. Maltese, Rosita A. Condorelli, Sandro La Vignera, Aldo E. Calogero
Summary: This study describes the clinical features of two unrelated patients with resistance to thyroid hormones. One patient carries a novel mutation and shows related symptoms, while the other has additional issues after childbirth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Yueting Ge, Yuhui Yang, Yuge Jiang, Chuanxing Feng, Bowen Li, Jin Sun, Xue Tang, Yonghui Shi, Guowei Le
Summary: Recent studies have found that high oxidative injury pork and Dityr intake induce oxidative stress and inflammation, impairing thyroid function and peripheral metabolism, leading to a decrease in circulating and liver thyroid hormones and induced hepatic steatosis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Paul Manka, Jason D. Coombes, Svenja Sydor, Marzena K. Swiderska-Syn, Jan Best, Karine Gauthier, Leo A. van Grunsven, Ye H. Oo, Cindy Wang, Anna M. Diehl, Georg S. Hoenes, Lars C. Moeller, Anja Figge, Rene J. Boosman, Klaas N. Faber, Andrea Tannapfel, Oliver Goetze, Patricia Aspichueta, Christian M. Lange, Ali Canbay, Wing-Kin Syn
Summary: Thyroid hormones play a crucial role in hepatic fibrogenesis by regulating the phenotype of hepatic stellate cells (HSC) via the TGF beta signaling pathway. In vitro experiments showed that T3 can inhibit the expression of fibrogenic genes and promote wound healing in HSC. In vivo experiments on TR alpha-deficient mice further confirmed the importance of the TH-TR axis in liver fibrosis.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Luis A. Videla, Rodrigo Valenzuela
Summary: Oxidative stress can disrupt redox signaling and control, leading to cellular dysfunction, with protective or harmful effects depending on the antioxidant potential of cells, levels of reactive oxygen/nitrogen species, and exposure time. Conditions like iron overload and NAFLD can cause redox imbalance, while thyroid hormones play a role in preconditioning the liver against ischemia-reperfusion injury.
Article
Nutrition & Dietetics
Jinwang Li, Siyu Xie, Wendi Teng
Summary: Sulforaphane (SFA) has the potential to improve lipid metabolism, inhibit lipid accumulation and apoptosis, making it a potential candidate for preventing and treating nonalcoholic fatty liver disease (NAFLD).
Review
Biochemistry & Molecular Biology
Paulina Vidal-Cevallos, Sofia Murua-Beltran Gall, Misael Uribe, Norberto C. Chavez-Tapia
Summary: The high prevalence of hypothyroidism in NAFLD patients suggests a possible involvement of thyroid dysfunction in the pathogenesis of NAFLD. Thyroid hormones regulate lipid and carbohydrate metabolism in the liver, and selective liver THR-beta agonists have shown promise in reducing liver fat content and improving nonalcoholic steatohepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrea Moran-Costoya, Ana M. Proenza, Magdalena Gianotti, Isabel Llado, Adamo Valle
Summary: Gender differences play a significant role in the pathogenesis of NAFLD, with new research providing interesting clues for the development of new therapeutic strategies, pointing to the higher protection females have against NAFLD.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Endocrinology & Metabolism
Bing Liu, Wei Yi, Xiaoxiang Mao, Ling Yang, Caijun Rao
Summary: The study found that ECH1 expression was significantly increased in human NASH biopsy specimens and in methionine choline-deficient (MCD) diet-fed mice. Overexpression of ECH1 alleviated hepatic steatosis, inflammation, fibrogenesis, apoptosis, and oxidative stress in mice, while also reducing alanine aminotransferase and proinflammatory cytokine levels in serum and triglyceride levels in livers. ECH1 may act as a potential therapeutic target for NASH by inhibiting ferroptosis.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Nadine Gehrke, Lea J. Hofmann, Beate K. Straub, Frank Ruehle, Ari Waisman, Peter R. Galle, Joern M. Schattenberg
Summary: This study investigates the contribution of hepatic interleukin-1 receptor type 1 (IL-1R1) signaling to insulin sensitivity in nonalcoholic fatty liver disease. The results show that hepatocyte IL-1R1 knockout mice maintain higher insulin sensitivity despite a high-fat, high-carbohydrate diet, with less hepatic inflammation and stable IL-1R1 signaling compared to wild-type mice.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Sushila Maharjan, Diana Bonilla, Princy Sindurakar, Hongbin Li, Wanlu Li, Sergio Duarte, Ali Zarrinpar, Y. Shrike Zhang
Summary: This study developed a three-dimensional human hepatic tissue model for emulating steatotic and fibrotic conditions, providing a valuable in vitro platform for drug testing and mechanistic studies. The model used photolithography biofabrication with specific inductions to successfully induce hepatic steatosis and fibrosis, and validated drug treatments for inhibiting these conditions.
BIO-DESIGN AND MANUFACTURING
(2021)
Review
Medicine, General & Internal
Anna Malgorzata Kucharska, Ewelina Witkowska-Sedek, Malgorzata Ruminska, Beata Pyrzak
Summary: This paper presents literature data describing changes in thyroid function related to rhGH therapy and provides a current explanation of the mechanisms involved in this phenomenon, emphasizing the importance of changes in central and peripheral regulation during treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Stephania Guzman, Magdalena Dragan, Hyokjoon Kwon, Vanessa de Oliveira, Shivani Rao, Vrushank Bhatt, Katarzyna M. Kalemba, Ankit Shah, Vinod K. Rustgi, He Wang, Paul R. Bech, Ali Abbara, Chioma Izzi-Engbeaya, Pinelopi Manousou, Jessie Y. Guo, Grace L. Guo, Sally Radovick, Waljit S. Dhillo, Fredric E. Wondisford, Andy Babwah, Moshmi Bhattacharya
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease associated with obesity, diabetes, and metabolic syndrome. Activation of the kisspeptin 1 receptor (KISS1R) signaling pathway has therapeutic effects in treating NAFLD.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Suwen Lin, Shengjian Huang, Zhou Deng, Yu Zhang, Lin Huang, Yanyi Wu, Shuyan Lv, Zhiyi Wang, Ning Huang, Lan Wang, Ziqi Chen, Guangyin Yu, Weihua Yin, You Zhou, Zhengyu Fang
Summary: In this study, a novel THR-beta agonist called CS271011 was discovered and its safety and efficiency compared to MGL-3196 were assessed. Results showed that CS271011 exhibited higher THR-beta activation in vitro compared to MGL-3196 and demonstrated favorable pharmacokinetic properties and liver enrichment in a diet-induced obesity mice model. Furthermore, CS271011 improved dyslipidemia and liver steatosis. Overall, CS271011 is a potent and liver-targeted THR-beta agonist for treating lipid metabolism disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Marco Giammanco, Manfredi Marco Giammanco
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Oncology
Gabriella Schiera, Carlo Maria Di Liegro, Italia Di Liegro
Summary: The development and function of the mammalian brain depends on precise regulation of gene expression by thyroid hormones, which act at multiple levels and cell types. Thyroid hormones have both genomic and non-genomic effects on brain cells, affecting proliferation, differentiation, and metabolism. Furthermore, thyroid hormone levels may influence cancer proliferation and invasion through complex interactions with their targets.
Article
Cell Biology
Yuta Kanamori, Alessia Finotti, Laura Di Magno, Gianluca Canettieri, Tomoaki Tahara, Fabio Timeus, Antonio Greco, Paola Tirassa, Jessica Gasparello, Pasquale Fino, Carlo Maria Di Liegro, Patrizia Proia, Gabriella Schiera, Italia Di Liegro, Roberto Gambari, Enzo Agostinelli
Summary: Neuroblastoma is a common malignant solid tumor in children, with N-Myc amplification being a poor prognostic marker in NB patients. Treatment with BSAO/SPM leads to increased mRNA levels of proapoptotic genes in NB cell lines, inducing apoptosis activity.
Article
Nutrition & Dietetics
Alessandra Amato, Paolo Ragonese, Sonia Ingoglia, Gabriella Schiera, Giuseppe Schiro, Carlo Maria Di Liegro, Giuseppe Salemi, Italia Di Liegro, Patrizia Proia
Summary: This study investigated the effects of lactacid anaerobic training on multiple sclerosis patients. The results showed that the exercise influenced BDNF and DHEAS levels, reduced baseline lactate levels, and increased self-efficacy and self-esteem in the patients.
Review
Chemistry, Multidisciplinary
Emanuele Salvatore Scarpa, Marco Giammanco, Mauro Magnani
Summary: Combining phytochemicals with anticancer drugs shows synergistic anticancer effects against gastrointestinal tumors, modulating molecular pathways and cancer biomarkers to improve efficacy in future clinical applications.
APPLIED SCIENCES-BASEL
(2021)
Review
Biology
Marco Giammanco, Fulvio Plescia, Manfredi M. Giammanco, Gaetano Leto, Carla Gentile
Summary: Citrus fruits are recognized for their beneficial effects on human health, which are attributed to their high content in vitamins, minerals, and fibers, as well as their antioxidant and anti-inflammatory activities. They have been shown to reduce the risk of chronic degenerative diseases such as atherosclerosis and cancer.
JOURNAL OF BIOLOGICAL RESEARCH-BOLLETTINO DELLA SOCIETA ITALIANA DI BIOLOGIA SPERIMENTALE
(2022)
Article
Genetics & Heredity
Gabriella Schiera, Patrizia Cancemi, Carlo Maria Di Liegro, Flores Naselli, Sara Volpes, Ilenia Cruciata, Paola Sofia Cardinale, Fabiola Vaglica, Matteo Calligaris, Anna Paola Carreca, Roberto Chiarelli, Simone Dario Scilabra, Olga Leone, Fabio Caradonna, Italia Di Liegro
Summary: Gliomas, especially astrocytomas, are the most frequent brain cancers, derived from glial cells. Astrocytes play essential roles in brain functions, but when they become cancerous, their functions are altered and they invade the brain tissue. Studying the molecular properties of transformed astrocytes is crucial for better understanding of this cancer.
Review
Biochemistry & Molecular Biology
Carlo Maria Di Liegro, Gabriella Schiera, Giuseppe Schiro, Italia Di Liegro
Summary: The post-transcriptional regulation of mRNA fate plays a central role in nervous system development and function. RNA-binding proteins (RBPs) control the maturation, localization, stability, and translation of transcripts by recognizing and binding RNA sequences, base modifications, or secondary/tertiary structures. RBPs, which often contain intrinsically disordered regions (IDRs), are involved in the formation of membrane-less structures and can form aggregates under altered cellular conditions. Additionally, RBPs can enter extracellular vesicles (EVs), allowing them to be transported to cells other than those that produced them.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)