Serine Protease Inhibitors in Ticks: An Overview of Their Role in Tick Biology and Tick-Borne Pathogen Transmission

Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo

(2016) Vania G. Branco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell

(2016) Katia L. P. Morais et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick–Host Interactions

(2016) Jindřich Chmelař et al.   TRENDS IN PARASITOLOGY

BmTI-A, a Kunitz type inhibitor from Rhipicephalus microplus able to interfere in vessel formation

(2016) Tatiane S. Soares et al.   VETERINARY PARASITOLOGY

Identification and the preliminary in vitro characterization of IRIS homologue from salivary glands of Ixodes persulcatus Schulze

(2016) Kochi Toyomane et al.   Ticks and Tick-Borne Diseases

Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the yeast Pichia pastoris

(2016) Tao Xu et al.   Ticks and Tick-Borne Diseases

Target validation of highly conserved Amblyomma americanum tick saliva serine protease inhibitor 19

(2016) Tae K. Kim et al.   Ticks and Tick-Borne Diseases

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus

(2016) Teresa C. Assumpção et al.   PLoS Neglected Tropical Diseases

Ixodes ricinus Salivary Serpin IRS-2 Affects Th17 Differentiation via Inhibition of the Interleukin-6/STAT-3 Signaling Pathway

(2015) Jana Páleníková et al.   INFECTION AND IMMUNITY

Conserved Amblyomma americanum tick Serpin19, an inhibitor of blood clotting factors Xa and XIa, trypsin and plasmin, has anti-haemostatic functions

(2015) Tae Kwon Kim et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Modulation of host immunity by tick saliva

(2015) Jan Kotál et al.   Journal of Proteomics

Midgut proteome of an argasid tick, Ornithodoros erraticus: a comparison between unfed and engorged females

(2015) Ana Oleaga et al.   Parasites & Vectors

Rhipicephalus microplus serine protease inhibitor family: annotation, expression and functional characterisation assessment

(2015) Manuel Rodriguez-Valle et al.   Parasites & Vectors

Saliva from nymph and adult females of Haemaphysalis longicornis: a proteomic study

(2015) Lucas Tirloni et al.   Parasites & Vectors

Bioinformatic analyses of male and female Amblyomma americanum tick expressed serine protease inhibitors (serpins)

(2015) Lindsay Porter et al.   Ticks and Tick-Borne Diseases

Deep Sequencing Analysis of the Ixodes ricinus Haemocytome

(2015) Michalis Kotsyfakis et al.   PLoS Neglected Tropical Diseases

CHARACTERIZATION OF A NEW KUNITZ-TYPE SERINE PROTEASE INHIBITOR FROM THE HARD TICKRhipicephalus hemaphysaloides

(2015) Jie Cao et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Identification and Mechanistic Analysis of a Novel Tick-Derived Inhibitor of Thrombin

(2015) Willy Jablonka et al.   PLoS One

RmKK, a tissue kallikrein inhibitor from Rhipicephalus microplus eggs

(2014) Patrícia A. Abreu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A 24-48 h fed Amblyomma americanum tick saliva immuno-proteome

(2014) Željko M Radulović et al.   BMC GENOMICS

A blood meal-induced Ixodes scapularis tick saliva serpin inhibits trypsin and thrombin, and interferes with platelet aggregation and blood clotting

(2014) Adriana M.G. Ibelli et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

A Systems Level Analysis Reveals Transcriptomic and Proteomic Complexity inIxodes RicinusMidgut and Salivary Glands During Early Attachment and Feeding

(2014) Alexandra Schwarz et al.   MOLECULAR & CELLULAR PROTEOMICS

The sialotranscriptome of Amblyomma triste, Amblyomma parvum and Amblyomma cajennense ticks, uncovered by 454-based RNA-seq

(2014) Gustavo Garcia et al.   Parasites & Vectors

Proteomic Analysis of Cattle Tick Rhipicephalus (Boophilus) microplus Saliva: A Comparison between Partially and Fully Engorged Females

(2014) Lucas Tirloni et al.   PLoS One

Transcriptome of the Female Synganglion of the Black-Legged Tick Ixodes scapularis (Acari: Ixodidae) with Comparison between Illumina and 454 Systems

(2014) Noble Egekwu et al.   PLoS One

Platelet Membrane Glycoproteins: A Historical Review

(2014) Alan Nurden   SEMINARS IN THROMBOSIS AND HEMOSTASIS

IrSPI, a Tick Serine Protease Inhibitor Involved in Tick Feeding and Bartonella henselae Infection

(2014) Xiang Ye Liu et al.   PLoS Neglected Tropical Diseases

Hard Tick Factors Implicated in Pathogen Transmission

(2014) Xiang Ye Liu et al.   PLoS Neglected Tropical Diseases

A family of serine protease inhibitors (serpins) in the cattle tick Rhipicephalus (Boophilus) microplus

(2013) Lucas Tirloni et al.   EXPERIMENTAL PARASITOLOGY

Amblyomma americanumtick saliva serine protease inhibitor 6 is a cross-class inhibitor of serine proteases and papain-like cysteine proteases that delays plasma clotting and inhibits platelet aggregation

(2013) A. Mulenga et al.   INSECT MOLECULAR BIOLOGY

Differential expression of Ixodes ricinus salivary gland proteins in the presence of the Borrelia burgdorferi sensu lato complex

(2013) Violaine Cotté et al.   Journal of Proteomics

Tryptogalinin Is a Tick Kunitz Serine Protease Inhibitor with a Unique Intrinsic Disorder

(2013) James J. Valdés et al.   PLoS One

Characterization of Ixophilin, A Thrombin Inhibitor from the Gut of Ixodes scapularis

(2013) Sukanya Narasimhan et al.   PLoS One

Isolation and characterization of two novel serpins from the tick Rhipicephalus haemaphysaloides

(2013) Yingfang Yu et al.   Ticks and Tick-Borne Diseases

Interaction of the tick immune system with transmitted pathogens

(2013) Ondřej Hajdušek et al.   Frontiers in Cellular and Infection Microbiology

Tick salivary compounds: their role in modulation of host defences and pathogen transmission

(2013) Mária Kazimírová et al.   Frontiers in Cellular and Infection Microbiology

Ticks and tick-borne pathogens at the cutaneous interface: host defenses, tick countermeasures, and a suitable environment for pathogen establishment

(2013) Stephen Wikel   Frontiers in Microbiology

Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis

(2012) Shao-Xing Dai et al.   BMC EVOLUTIONARY BIOLOGY

Structure and function of invertebrate Kunitz serine protease inhibitors

(2012) Shiwanthi Ranasinghe et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Tick control practices in Burkina Faso and acaricide resistance survey in Rhipicephalus (Boophilus) geigyi (Acari: Ixodidae)

(2012) Hassane Adakal et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

A hemocyte-derived Kunitz–BPTI-type chymotrypsin inhibitor, HlChI, from the ixodid tick Haemaphysalis longicornis, plays regulatory functions in tick blood-feeding processes

(2012) M. Abdul Alim et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Plasmin as a proinflammatory cell activator

(2012) T. Syrovets et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis

(2012) C.C. Drewes et al.   TOXICON

Ticks and tick-borne diseases: a One Health perspective

(2012) Filipe Dantas-Torres et al.   TRENDS IN PARASITOLOGY

Protective immunity against tick infestation in cattle vaccinated with recombinant trypsin inhibitor of Rhipicephalus microplus

(2012) Renato Andreotti et al.   VACCINE

Expression and functional characterization of boophilin, a thrombin inhibitor from Rhipicephalus (Boophilus) microplus midgut

(2012) Tatiane Sanches Soares et al.   VETERINARY PARASITOLOGY

Differential recognition by tick-resistant cattle of the recombinantly expressed Rhipicephalus microplus serine protease inhibitor-3 (RMS-3)

(2012) Manuel Rodriguez-Valle et al.   Ticks and Tick-Borne Diseases

Synganglion transcriptome and developmental global gene expression in adult females of the American dog tick, Dermacentor variabilis (Acari: Ixodidae)

(2011) B. W. Bissinger et al.   INSECT MOLECULAR BIOLOGY

Amblyomma americanum (L.) (Acari: Ixodidae) tick salivary gland serine protease inhibitor (serpin) 6 is secreted into tick saliva during tick feeding

(2011) K. C. Chalaire et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

An insight into the sialotranscriptome and proteome of the coarse bontlegged tick, Hyalomma marginatum rufipes

(2011) Ivo M.B. Francischetti et al.   Journal of Proteomics

Serpin structure, function and dysfunction

(2011) J. A. HUNTINGTON   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus

(2011) Zdeněk Franta et al.   Parasites & Vectors

Protease inhibitors and proteolytic signalling cascades in insects

(2010) David Gubb et al.   BIOCHIMIE

A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation

(2010) J. Chmelar et al.   BLOOD

A proteomics approach for the analysis of hemolymph proteins involved in the immediate defense response of the soft tick, Ornithodoros savignyi, when challenged with Candida albicans

(2010) Elaine Stopforth et al.   EXPERIMENTAL AND APPLIED ACAROLOGY

A Kunitz Protease Inhibitor fromDermacentor variabilis, a Vector for Spotted Fever Group Rickettsiae, LimitsRickettsia montanensisInvasion

(2010) Shane M. Ceraul et al.   INFECTION AND IMMUNITY

Characterization of the anticoagulant protein Rhipilin-1 from the Rhipicephalus haemaphysaloides tick

(2010) Xiao Gao et al.   JOURNAL OF INSECT PHYSIOLOGY

Serine proteases of the human immune system in health and disease

(2010) Kirstin M. Heutinck et al.   MOLECULAR IMMUNOLOGY

A new tick Kunitz type inhibitor, Amblyomin-X, induces tumor cell death by modulating genes related to the cell cycle and targeting the ubiquitin-proteasome system

(2010) Ana Marisa Chudzinski-Tavassi et al.   TOXICON

A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

(2009) I.F.C. Batista et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Hepcidin, the hormone of iron metabolism, is bound specifically to  -2-macroglobulin in blood

(2009) G. Peslova et al.   BLOOD

High sequence variability among hemocyte-specific Kazal-type proteinase inhibitors in decapod crustaceans

(2009) Lage Cerenius et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Structure and function of invertebrate Kazal-type serine proteinase inhibitors

(2009) Vichien Rimphanitchayakit et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Exosites mediate the anti-inflammatory effects of a multifunctional serpin from the saliva of the tickIxodes ricinus

(2009) Pierre-Paul Prevot et al.   FEBS Journal

Characterization, kinetics, and possible function of Kazal-type proteinase inhibitors of Chinese white shrimp, Fenneropenaeus chinensis

(2009) Zong-Heng Wang et al.   FISH & SHELLFISH IMMUNOLOGY

The role of saliva in tick feeding

(2009) Ivo et al.   Frontiers in Bioscience-Landmark

Genetic basis and impact of tick acaricide resistance

(2009) Rodrigo Rosario-Cruz   Frontiers in Bioscience-Landmark

Ir-CPI, a coagulation contact phase inhibitor from the tickIxodes ricinus, inhibits thrombus formation without impairing hemostasis

(2009) Yves Decrem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Kunitz-type proteinase inhibitor from the midgut of the ixodid tick, Haemaphysalis longicornis, and its endogenous target serine proteinase

(2009) Takeharu Miyoshi et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells

(2009) Tsugunobu Andoh et al.   PEPTIDES

Biochemical characterization of a Kunitz type inhibitor similar to dendrotoxins produced by Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) hemocytes

(2009) Cássia A. Lima et al.   VETERINARY PARASITOLOGY

The Kunitz-Like Modulatory Protein Haemangin Is Vital for Hard Tick Blood-Feeding Success

(2009) M. Khyrul Islam et al.   PLoS Pathogens

Exploring the mialome of ticks: An annotated catalogue of midgut transcripts from the hard tick, Dermacentor variabilis (Acari: Ixodidae)

(2008) Jennifer M Anderson et al.   BMC GENOMICS

IrAM—An α2-macroglobulin from the hard tick Ixodes ricinus: Characterization and function in phagocytosis of a potential pathogen Chryseobacterium indologenes

(2008) Veronika Buresova et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Functional Characterization and Novel Rickettsiostatic Effects of a Kunitz-Type Serine Protease Inhibitor from the Tick Dermacentor variabilis

(2008) S. M. Ceraul et al.   INFECTION AND IMMUNITY

Hemalin, a thrombin inhibitor isolated from a midgut cDNA library from the hard tick Haemaphysalis longicornis

(2008) Min Liao et al.   JOURNAL OF INSECT PHYSIOLOGY

Insect vitellogenin/lipophorin receptors: Molecular structures, role in oogenesis, and regulatory mechanisms

(2008) Muhammad Tufail et al.   JOURNAL OF INSECT PHYSIOLOGY

Structure of and influence of a tick complement inhibitor on human complement component 5

(2008) Folmer Fredslund et al.   NATURE IMMUNOLOGY

Isolation, Cloning and Structural Characterisation of Boophilin, a Multifunctional Kunitz-Type Proteinase Inhibitor from the Cattle Tick

(2008) Sandra Macedo-Ribeiro et al.   PLoS One

rBmTI-6, a Kunitz-BPTI domain protease inhibitor from the tick Boophilus microplus, its cloning, expression and biochemical characterization

(2008) Sergio D. Sasaki et al.   VETERINARY PARASITOLOGY

BmSI-7, a novel subtilisin inhibitor from Boophilus microplus, with activity toward Pr1 proteases from the fungus Metarhizium anisopliae

(2007) Sergio D. Sasaki et al.   EXPERIMENTAL PARASITOLOGY

Characterization of anti-hemostatic factors in the argasid, Argas monolakensis: Implications for the evolution of blood-feeding in the soft tick family

(2007) Ben J. Mans et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY