Extracellular vesicles through the blood–brain barrier: a review

The Role of Extracellular Vesicles in the Pathogenesis and Treatment of Autoimmune Disorders

(2021) Mengrou Lu et al.   Frontiers in Immunology

A Microfluidic Multisize Spheroid Array for Multiparametric Screening of Anticancer Drugs and Blood–Brain Barrier Transport Properties

(2021) Christoph Eilenberger et al.   Advanced Science

L1CAM is not associated with extracellular vesicles in human cerebrospinal fluid or plasma

(2021) Maia Norman et al.   NATURE METHODS

Engineered extracellular vesicles as brain therapeutics

(2021) Miguel M. Lino et al.   JOURNAL OF CONTROLLED RELEASE

The function and clinical application of extracellular vesicles in innate immune regulation

(2020) Xiaoxue Zhou et al.   Cellular & Molecular Immunology

Transport of Extracellular Vesicles across the Blood-Brain Barrier: Brain Pharmacokinetics and Effects of Inflammation

(2020) William A. Banks et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles in the Development of Cancer Therapeutics

(2020) Haoyao Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Photonic-chip assisted correlative light and electron microscopy

(2020) Jean-Claude Tinguely et al.   Communications Biology

Exosomes: biogenesis, biologic function and clinical potential

(2019) Yuan Zhang et al.   Cell and Bioscience

The biology of extracellular vesicles: The known unknowns

(2019) Leonid Margolis et al.   PLOS BIOLOGY

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

(2019) Laura M. Doyle et al.   Cells

Tumor-Derived Extracellular Vesicles Breach the Intact Blood–Brain Barrier via Transcytosis

(2019) Golnaz Morad et al.   ACS Nano

Suppression of transcytosis regulates zebrafish blood-brain barrier function

(2019) Natasha M O'Brown et al.   eLife

Blood brain barrier: A tissue engineered microfluidic chip

(2019) Sikkandhar Musafargani et al.   JOURNAL OF NEUROSCIENCE METHODS

The Transport Mechanism of Extracellular Vesicles at the Blood-Brain Barrier

(2018) Junichi Matsumoto et al.   CURRENT PHARMACEUTICAL DESIGN

Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer’s disease

(2018) Edward J. Goetzl et al.   FASEB JOURNAL

Bridging barriers: a comparative look at the blood–brain barrier across organisms

(2018) Natasha M. O'Brown et al.   GENES & DEVELOPMENT

High-vacuum optical platform for cryo-CLEM (HOPE): A new solution for non-integrated multiscale correlative light and electron microscopy

(2018) Shuoguo Li et al.   JOURNAL OF STRUCTURAL BIOLOGY

Extracellular vesicles in cancer — implications for future improvements in cancer care

(2018) Rong Xu et al.   Nature Reviews Clinical Oncology

Cluster of Differentiation 46 Is the Major Receptor in Human Blood–Brain Barrier Endothelial Cells for Uptake of Exosomes Derived from Brain-Metastatic Melanoma Cells (SK-Mel-28)

(2018) Hiroki Kuroda et al.   MOLECULAR PHARMACEUTICS

Insight into Cellular Uptake and Intracellular Trafficking of Nanoparticles

(2018) Parisa Foroozandeh et al.   Nanoscale Research Letters

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics

(2018) Sonja Bergmann et al.   Nature Protocols

Double-slit photoelectron interference in strong-field ionization of the neon dimer

(2018) Maksim Kunitski et al.   Nature Communications

Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

(2017) Colin M. Fadzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice

(2017) Weijian Zong et al.   NATURE METHODS

Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents

(2017) Choi-Fong Cho et al.   Nature Communications

Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model

(2017) Shi-Cong Tao et al.   Theranostics

Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson’s disease?

(2017) Junichi Matsumoto et al.   Acta Neuropathologica Communications

Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

(2017) Lawrence Vernetti et al.   Scientific Reports

Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis

(2017) Lingling Bai et al.   Scientific Reports

Elucidation of Exosome Migration Across the Blood–Brain Barrier Model In Vitro

(2016) Claire C. Chen et al.   Cellular and Molecular Bioengineering

Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Role of exosomes in the protection of cellular homeostasis

(2016) Gabriela Desdín-Micó et al.   Cell Adhesion & Migration

DNA sequences within glioma-derived extracellular vesicles can cross the intact blood-brain barrier and be detected in peripheral blood of patients

(2016) Noemí García-Romero et al.   Oncotarget

Plasma neuronal exosomal levels of Alzheimer's disease biomarkers in normal aging

(2016) Erin L. Abner et al.   Annals of Clinical and Translational Neurology

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC

(2015) Benjamin Besse et al.   OncoImmunology

Imaging Approach to Mechanistic Study of Nanoparticle Interactions with the Blood–Brain Barrier

(2014) Mattia Bramini et al.   ACS Nano

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Tissue-engineered microenvironment systems for modeling human vasculature

(2014) Anna Tourovskaia et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer’s disease

(2014) CHEN-GENG LIU et al.   Molecular Medicine Reports

Notch3 establishes brain vascular integrity by regulating pericyte number

(2013) Y. Wang et al.   DEVELOPMENT

Exosomes: Looking back three decades and into the future

(2013) Clifford V. Harding et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Functional Characterisation of the Maturation of the Blood-Brain Barrier in Larval Zebrafish

(2013) Angeleen Fleming et al.   PLoS One

Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

(2013) Marcel Grapp et al.   Nature Communications

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier

(2013) Eduard Urich et al.   Scientific Reports

Penetration and differentiation of cephalic neural crest-derived cells in the developing mouse telencephalon

(2012) Emiko Yamanishi et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Exosomes as intercellular signalosomes and pharmacological effectors

(2011) Michel Record et al.   BIOCHEMICAL PHARMACOLOGY

Immunosuppressive exosomes from TGF-β1 gene-modified dendritic cells attenuate Th17-mediated inflammatory autoimmune disease by inducing regulatory T cells

(2011) Zhijian Cai et al.   CELL RESEARCH

Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver

(2010) Kinji Asahina et al.   HEPATOLOGY

Astroglial structures in the zebrafish brain

(2010) Larissa Grupp et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway

(2008) N. Izquierdo-Useros et al.   BLOOD

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Mesothelium contributes to vascular smooth muscle and mesenchyme during lung development

(2008) J. Que et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional and developmental analysis of the blood–brain barrier in zebrafish

(2007) Jae-Yeon Jeong et al.   BRAIN RESEARCH BULLETIN