Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes

Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

(2021) Joshua T. Weinreb et al.   DEVELOPMENTAL CELL

Cytosolic dsDNA is a novel senescence marker associated with pyroptosis activation

(2021) Ruoyu Zhou et al.   TISSUE & CELL

Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs

(2020) Tomoya Muto et al.   NATURE IMMUNOLOGY

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation

(2020) Shaima’a Hamarsheh et al.   Nature Communications

STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

(2020) Wenbiao Wang et al.   PLoS Pathogens

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling

(2019) Daniel A. Pollyea et al.   HAEMATOLOGICA

High-resolution, strand-specific R-loop mapping via S9.6-based DNA–RNA immunoprecipitation and high-throughput sequencing

(2019) Lionel A. Sanz et al.   Nature Protocols

Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis

(2019) Jong Jin Jeong et al.   Cancer Discovery

Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1

(2019) Sylwia D. Tyrkalska et al.   IMMUNITY

Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry

(2019) Silvia Lucena Lage et al.   Frontiers in Immunology

Srsf2P95Hinitiates myeloid bias and myelodysplastic/myeloproliferative syndrome (MDS/MPN) from hemopoietic stem cells

(2018) Monique F. Smeets et al.   BLOOD

The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations

(2018) Liang Chen et al.   MOLECULAR CELL

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

(2018) Mingjian Du et al.   SCIENCE

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

(2018) Fiachra Humphries et al.   Nature Communications

A TRAF3-NIK module differentially regulates DNA vs RNA pathways in innate immune signaling

(2018) Kislay Parvatiyar et al.   Nature Communications

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion

(2018) Vikas Madan et al.   HAEMATOLOGICA

Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study

(2018) Ashley A Basiorka et al.   Lancet Haematology

The U2AF1S34F mutation induces lineage-specific splicing alterations in myelodysplastic syndromes

(2017) Bon Ham Yip et al.   JOURNAL OF CLINICAL INVESTIGATION

A noncanonical function of cGAMP in inflammasome priming and activation

(2017) Karen V. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

(2017) José J. Fuster et al.   SCIENCE

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice

(2017) Jessica Vincent et al.   Nature Communications

IFI16, an amplifier of DNA-damage response: Role in cellular senescence and aging-associated inflammatory diseases

(2016) Divaker Choubey et al.   AGEING RESEARCH REVIEWS

The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype

(2016) A. A. Basiorka et al.   BLOOD

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

(2016) Emna Mahfoudhi et al.   DNA REPAIR

The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA

(2016) Elizabeth E. Gray et al.   IMMUNITY

Activation of STING requires palmitoylation at the Golgi

(2016) Kojiro Mukai et al.   Nature Communications

SRSF2 Mutations Contribute to Myelodysplasia by Mutant-Specific Effects on Exon Recognition

(2015) Eunhee Kim et al.   CANCER CELL

RNA Polymerase III Regulates Cytosolic RNA:DNA Hybrids and Intracellular MicroRNA Expression

(2015) Christine Xing'er Koo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections

(2014) S M Dauphinee et al.   GENES AND IMMUNITY

A 3-microRNA scoring system for prognostication in de novo acute myeloid leukemia patients

(2014) M-K Chuang et al.   LEUKEMIA

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing

(2014) Dirk Heckl et al.   NATURE BIOTECHNOLOGY

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Induction of myelodysplasia by myeloid-derived suppressor cells

(2013) Xianghong Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Involvement of A20 in the molecular switch that activates the non-canonical NF-кB pathway

(2013) Noritaka Yamaguchi et al.   Scientific Reports

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Tet2 Loss Leads to Increased Hematopoietic Stem Cell Self-Renewal and Myeloid Transformation

(2011) Kelly Moran-Crusio et al.   CANCER CELL

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

(2011) Konstantina Skourti-Stathaki et al.   MOLECULAR CELL

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

(2011) M. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA