Potential Cross Talk between Autism Risk Genes and Neurovascular Molecules: A Pilot Study on Impact of Blood Brain Barrier Integrity

A Preliminary Report: The Hippocampus and Surrounding Temporal Cortex of Patients With Schizophrenia Have Impaired Blood-Brain Barrier

(2022) Eric L. Goldwaser et al.   Frontiers in Human Neuroscience

Schizophrenia-derived hiPSC brain microvascular endothelial-like cells show impairments in angiogenesis and blood–brain barrier function

(2022) Bárbara S. Casas et al.   MOLECULAR PSYCHIATRY

Increased blood-brain barrier permeability of the thalamus and the correlation with symptom severity and brain volume alterations in schizophrenia patients

(2022) Yuqi Cheng et al.   Biological Psychiatry-Cognitive Neuroscience and Neuroimaging

Potential crosstalk between sonic hedgehog‐WNT signaling and neurovascular molecules: Implications for blood–brain barrier integrity in autism spectrum disorder

(2021) Evelyne Gozal et al.   JOURNAL OF NEUROCHEMISTRY

The use of biomarkers associated with leaky gut as a diagnostic tool for early intervention in autism spectrum disorder: a systematic review

(2021) Laila Al-Ayadhi et al.   Gut Pathogens

Inflammatory Subtypes in Antipsychotic-Naïve First-Episode Schizophrenia are Associated with Altered Brain Morphology and Topological Organization

(2021) Dung Hoang et al.   BRAIN BEHAVIOR AND IMMUNITY

Endothelial Semaphorin 3F Maintains Endothelial Barrier Function and Inhibits Monocyte Migration

(2020) Huayu Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revisiting the functional anatomy of the human brain: Toward a meta-networking theory of cerebral functions

(2020) Guillaume Herbet et al.   PHYSIOLOGICAL REVIEWS

Gender-Specific Effect of 5-HT and 5-HIAA on Threshold Level of Behavioral Symptoms and Sex-Bias in Prevalence of Autism Spectrum Disorder

(2020) Barnali Chakraborti et al.   Frontiers in Neuroscience

Semaphorin 3F signaling actively retains neutrophils at sites of inflammation

(2020) Tracie Plant et al.   JOURNAL OF CLINICAL INVESTIGATION

State of the Art of Genetic Testing for Patients With Autism: A Practical Guide for Clinicians

(2020) Bracha L. Kreiman et al.   Seminars in Pediatric Neurology

Blood-Brain Barrier: More Contributor to Disruption of Central Nervous System Homeostasis Than Victim in Neurological Disorders

(2020) Minjia Xiao et al.   Frontiers in Neuroscience

Social Cognition in a Research Domain Criteria Perspective: A Bridge Between Schizophrenia and Autism Spectra Disorders

(2020) Stefano Barlati et al.   Frontiers in Psychiatry

Understanding Abnormal SMO-SHH Signaling in Autism Spectrum Disorder: Potential Drug Target and Therapeutic Goals

(2020) Saloni Rahi et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Identifying brain areas correlated with ADOS raw scores by studying altered dynamic functional connectivity patterns

(2020) Omar Dekhil et al.   MEDICAL IMAGE ANALYSIS

Semaphorin Signaling in Cancer-Associated Inflammation

(2019) Giulia Franzolin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deletion of Semaphorin 3F in Interneurons Is Associated with Decreased GABAergic Neurons, Autism-like Behavior, and Increased Oxidative Stress Cascades

(2019) Zhu Li et al.   MOLECULAR NEUROBIOLOGY

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

(2019) Yuxing Liao et al.   NUCLEIC ACIDS RESEARCH

Development and Cell Biology of the Blood-Brain Barrier

(2019) Urs H. Langen et al.   Annual Review of Cell and Developmental Biology

Redefining the Etiologic Landscape of Cerebellar Malformations

(2019) Kimberly A. Aldinger et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanistic insights into autocrine and paracrine roles of endothelial GABA signaling in the embryonic forebrain

(2019) Yong Kee Choi et al.   Scientific Reports

Cognitive Behavioral Treatments for Anxiety in Children With Autism Spectrum Disorder

(2019) Jeffrey J. Wood et al.   JAMA Psychiatry

Endothelial tight junctions and their regulatory signaling pathways in vascular homeostasis and disease

(2019) Xin Cong et al.   CELLULAR SIGNALLING

Paroxysmal slow cortical activity in Alzheimer’s disease and epilepsy is associated with blood-brain barrier dysfunction

(2019) Dan Z. Milikovsky et al.   Science Translational Medicine

Mutations in MICAL-1 cause autosomal-dominant lateral temporal epilepsy

(2018) Emanuela Dazzo et al.   ANNALS OF NEUROLOGY

Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation

(2018) Kshama Ohja et al.   NEUROMOLECULAR MEDICINE

Blood-brain barrier regulation in psychiatric disorders

(2018) John Kealy et al.   NEUROSCIENCE LETTERS

EEG Analytics for Early Detection of Autism Spectrum Disorder: A data-driven approach

(2018) William J. Bosl et al.   Scientific Reports

Systematic reconstruction of autism biology from massive genetic mutation profiles

(2018) Weijun Luo et al.   Science Advances

Electroencephalogram (EEG) for children with autism spectrum disorder: evidential considerations for routine screening

(2018) Ronald J. Swatzyna et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

The Neuroprotective Roles of Sonic Hedgehog Signaling Pathway in Ischemic Stroke

(2018) Lian Liu et al.   NEUROCHEMICAL RESEARCH

Lost in Translation: Traversing the Complex Path from Genomics to Therapeutics in Autism Spectrum Disorder

(2018) Nenad Sestan et al.   NEURON

Blood-Brain Barrier: From Physiology to Disease and Back

(2018) Melanie D. Sweeney et al.   PHYSIOLOGICAL REVIEWS

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response

(2018) Sara Bachiller et al.   Frontiers in Cellular Neuroscience

Brain hyperserotonemia causes autism-relevant social deficits in mice

(2018) Miho Tanaka et al.   Molecular Autism

Role of neuropilin-2 in the immune system

(2017) S. Schellenburg et al.   MOLECULAR IMMUNOLOGY

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia

(2017) P Steullet et al.   MOLECULAR PSYCHIATRY

Corticostriatal circuit defects in Hoxb8 mutant mice

(2017) N Nagarajan et al.   MOLECULAR PSYCHIATRY

Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity

(2017) Brian O. Orr et al.   NATURE

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder

(2017) Ryan K C Yuen et al.   NATURE NEUROSCIENCE

Neuropilin-2/PlexinA3 Receptors Associate with GluA1 and Mediate Sema3F-Dependent Homeostatic Scaling in Cortical Neurons

(2017) Qiang Wang et al.   NEURON

Immunomodulatory Functions of Neuronal Guidance Proteins

(2017) Valbona Mirakaj et al.   TRENDS IN IMMUNOLOGY

Microglia Morphological Categorization in a Rat Model of Neuroinflammation by Hierarchical Cluster and Principal Components Analysis

(2017) María del Mar Fernández-Arjona et al.   Frontiers in Cellular Neuroscience

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

(2017) Sohini Roy et al.   Frontiers in Immunology

Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study

(2017) Dae-Wook Kang et al.   Microbiome

How Useful Is Electroencephalography in the Diagnosis of Autism Spectrum Disorders and the Delineation of Subtypes: A Systematic Review

(2017) Oana Gurau et al.   Frontiers in Psychiatry

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency

(2016) Patrick Mucka et al.   AMERICAN JOURNAL OF PATHOLOGY

Memantine ameliorates autistic behavior, biochemistry & blood brain barrier impairments in rats

(2016) Hariom Kumar et al.   BRAIN RESEARCH BULLETIN

Neuropilin 2 Signaling Is Involved in Cell Positioning of Adult-born Neurons through Glycogen Synthase Kinase-3β (GSK3β)

(2016) Teclise Ng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting the role of redox signaling in neuronal development

(2016) Daniel A. Bórquez et al.   JOURNAL OF NEUROCHEMISTRY

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-  Oligomers in Mice

(2016) J. H. Ledo et al.   JOURNAL OF NEUROSCIENCE

The serotonin system in autism spectrum disorder: From biomarker to animal models

(2016) C.L. Muller et al.   NEUROSCIENCE

Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse

(2016) Ikuo Matsuda et al.   Molecular Brain

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders

(2016) Maria Fiorentino et al.   Molecular Autism

Synaptic Wnt/GSK3βSignaling Hub in Autism

(2016) Mario O. Caracci et al.   NEURAL PLASTICITY

Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins

(2015) Hironao Nakayama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammatory profiles in the BTBR mouse: How relevant are they to autism spectrum disorders?

(2015) Milo Careaga et al.   BRAIN BEHAVIOR AND IMMUNITY

Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1

(2015) Jun Rao et al.   CANCER LETTERS

Role of Microglia in Autism: Recent Advances

(2015) Tomoyuki Takano   DEVELOPMENTAL NEUROSCIENCE

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Benefits of agomelatine in behavioral, neurochemical and blood brain barrier alterations in prenatal valproic acid induced autism spectrum disorder

(2015) Hariom Kumar et al.   NEUROCHEMISTRY INTERNATIONAL

Fluoxetine and S-citalopram inhibit M1 activation and promote M2 activation of microglia in vitro

(2015) F. Su et al.   NEUROSCIENCE

Serotonin mediated immunoregulation and neural functions: Complicity in the aetiology of autism spectrum disorders

(2015) Preeti Jaiswal et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The role of platelets in the recruitment of leukocytes during vascular disease

(2015) G. Ed Rainger et al.   PLATELETS

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

(2015) Hironao Nakayama et al.   Scientific Reports

Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice

(2015) Shinya Yufune et al.   Scientific Reports

Platelet studies in autism spectrum disorder patients and first-degree relatives

(2015) Nora Bijl et al.   Molecular Autism

Altered hippocampal-dependent memory and motor function in neuropilin 2–deficient mice

(2015) M W Shiflett et al.   Translational Psychiatry

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

(2014) Rona Baron et al.   AGING CELL

Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis

(2014) Stefano Gabriele et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Model-based hypothesis of gut microbe populations and gut/brain barrier permeabilities in the development of regressive autism

(2014) Ryan Downs et al.   MEDICAL HYPOTHESES

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Semaphorin 3F and Neuropilin-2 Control the Migration of Human T-Cell Precursors

(2014) Daniella Arêas Mendes-da-Cruz et al.   PLoS One

The gut microbiota influences blood-brain barrier permeability in mice

(2014) V. Braniste et al.   Science Translational Medicine

Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells

(2014) Janel E. Le Belle et al.   Stem Cell Reports

Regulation of β-catenin stabilization in human platelets

(2013) Sharda Kumari et al.   BIOCHIMIE

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Global increases in both common and rare copy number load associated with autism

(2013) Santhosh Girirajan et al.   HUMAN MOLECULAR GENETICS

MICAL, the Flavoenzyme Participating in Cytoskeleton Dynamics

(2013) Maria Vanoni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Neuropilin signalling in vessels, neurons and tumours

(2013) Claudio Raimondi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Neurotransmitter signaling in the pathophysiology of microglia

(2013) María Domercq et al.   Frontiers in Cellular Neuroscience

Microglia and synapse interactions: fine tuning neural circuits and candidate molecules

(2013) Akiko Miyamoto et al.   Frontiers in Cellular Neuroscience

Autonomous vascular networks synchronize GABA neuron migration in the embryonic forebrain

(2013) Chungkil Won et al.   Nature Communications

Inflammatory macrophage phenotype in BTBR T+tf/J mice

(2013) Charity E. Onore et al.   Frontiers in Neuroscience

Platelet serotonin promotes the recruitment of neutrophils to sites of acute inflammation in mice

(2012) D. Duerschmied et al.   BLOOD

Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances

(2012) Wei-Ye Liu et al.   CNS Neuroscience & Therapeutics

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

(2012) Uwe Heinemann et al.   GLIA

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Deficiency of the Microglial Receptor CX3CR1 Impairs Postnatal Functional Development of Thalamocortical Synapses in the Barrel Cortex

(2012) M. Hoshiko et al.   JOURNAL OF NEUROSCIENCE

Hypothesis for a systems connectivity model of autism spectrum disorder pathogenesis: Links to gut bacteria, oxidative stress, and intestinal permeability

(2012) Colin A. Heberling et al.   MEDICAL HYPOTHESES

Downregulating the Canonical Wnt/β-catenin Signaling Pathway Attenuates the Susceptibility to Autism-like Phenotypes by Decreasing Oxidative Stress

(2012) Yinghua Zhang et al.   NEUROCHEMICAL RESEARCH

Evidence of oxidative damage and inflammation associated with low glutathione redox status in the autism brain

(2012) S Rose et al.   Translational Psychiatry

Platelet-mediated vascular dysfunction during acute lung injury

(2012) James T. Dixon et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Class 3 semaphorins and their receptors in physiological and pathological angiogenesis: Figure 1

(2011) Carolyn A. Staton   BIOCHEMICAL SOCIETY TRANSACTIONS

An important role of lymphatic vessel activation in limiting acute inflammation

(2011) R. Huggenberger et al.   BLOOD

The role of immune dysfunction in the pathophysiology of autism

(2011) Charity Onore et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia Phenotype Diversity

(2011) M. Olah et al.   CNS & Neurological Disorders-Drug Targets

Platelets: a critical link between inflammation and microvascular dysfunction

(2011) Karen Y. Stokes et al.   JOURNAL OF PHYSIOLOGY-LONDON

How platelets safeguard vascular integrity

(2011) B. HO-TIN-NOÉ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

The role of semaphorins and their receptors in platelets: Lessons learned from neuronal and immune synapses

(2011) Kenneth M. Wannemacher et al.   PLATELETS

Neuropilin-2 Mediated β-Catenin Signaling and Survival in Human Gastro-Intestinal Cancer Cell Lines

(2011) Shaija Samuel et al.   PLoS One

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Genetics of autism spectrum disorders

(2011) Daniel H. Geschwind   TRENDS IN COGNITIVE SCIENCES

Alterations of GABAergic Signaling in Autism Spectrum Disorders

(2011) Rocco Pizzarelli et al.   NEURAL PLASTICITY

Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still counting

(2010) Catalina Betancur   BRAIN RESEARCH

Detection of Abnormalities for Diagnosing of Children with Autism Disorders Using of Quantitative Electroencephalography Analysis

(2010) Ali Sheikhani et al.   JOURNAL OF MEDICAL SYSTEMS

Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2

(2010) Geoffrey C.Y. Tan et al.   NEUROIMAGE

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

Alzheimer's disease peptide  -amyloid interacts with fibrinogen and induces its oligomerization

(2010) H. J. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2

(2010) A. A. Scott-Van Zeeland et al.   Science Translational Medicine

Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease

(2009) Robert D. Bell et al.   ACTA NEUROPATHOLOGICA

Platelet α-granules: Basic biology and clinical correlates

(2009) Price Blair et al.   BLOOD REVIEWS

Molecular mechanisms of endothelial hyperpermeability: implications in inflammation

(2009) Puneet Kumar et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing

(2009) Liseth M Parra et al.   NATURE NEUROSCIENCE

Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: Implications for autism and epilepsy

(2008) John C. Gant et al.   EPILEPSIA

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Canonical Wnt Signaling Regulates Organ-Specific Assembly and Differentiation of CNS Vasculature

(2008) J. M. Stenman et al.   SCIENCE