The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells

Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance

(2021) Christina Andronikou et al.   TRENDS IN MOLECULAR MEDICINE

Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines

(2021) Patrycja Gralewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Olaparib: A Review as First-Line Maintenance Therapy in Advanced Ovarian Cancer

(2021) Julia Paik   Targeted Oncology

Update on Poly ADP-Ribose Polymerase Inhibitors in Ovarian Cancer With Non-BRCA Mutations

(2021) Qin Xu et al.   Frontiers in Pharmacology

Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells

(2020) Rebecca L. Lloyd et al.   ONCOGENE

Chemical modification of melphalan as a key to improving treatment of haematological malignancies

(2020) Arkadiusz Gajek et al.   Scientific Reports

ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms

(2020) Harriet E. D. Southgate et al.   Cancers

Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods

(2020) Nuzhat Ahmed et al.   Cells

Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells

(2020) Miriam K. Gomez et al.   Cancers

Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer

(2020) Xuan-zhang Huang et al.   Frontiers in Oncology

PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality—An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness

(2020) Patrycja Gralewska et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Suppression of autophagy enhances preferential toxicity of Epothilone A and Epothilone B in ovarian cancer cells

(2019) Aneta Rogalska et al.   PHYTOMEDICINE

Mitotic functions of poly(ADP-ribose) polymerases

(2019) Dea Slade   BIOCHEMICAL PHARMACOLOGY

Differential activity of ATR and WEE1 inhibitors in a highly sensitive subpopulation of DLBCL linked to replication stress

(2019) Lucy A. Young et al.   CANCER RESEARCH

Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence

(2019) Hubert Fleury et al.   Nature Communications

Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling and cytotoxicity in BRCA2‐deficient cancer cells

(2019) Pepijn M. Schoonen et al.   Molecular Oncology

Low-Dose and Long-Term Olaparib Treatment Sensitizes MDA-MB-231 and SUM1315 Triple-Negative Breast Cancers Spheroids to Fractioned Radiotherapy

(2019) Clémence Dubois et al.   Journal of Clinical Medicine

Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib

(2018) Polly Gravells et al.   DNA REPAIR

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

(2018) Jone Michelena et al.   Nature Communications

An intrinsic S/G2 checkpoint enforced by ATR

(2018) Joshua C. Saldivar et al.   SCIENCE

Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management

(2018) RR Bonadio et al.   Clinics

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma

(2017) V Colicchia et al.   ONCOGENE

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

(2017) Pepijn M. Schoonen et al.   Nature Communications

PARP inhibition causes premature loss of cohesion in cancer cells

(2017) Eva Kukolj et al.   Oncotarget

The G2 checkpoint-a node-based molecular switch

(2017) Mark C. de Gooijer et al.   FEBS Open Bio

Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells

(2016) Aneta Balcerczyk et al.   BIOCHEMICAL PHARMACOLOGY

Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models

(2016) Hyoung Kim et al.   CLINICAL CANCER RESEARCH

Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei

(2016) Magnus T. Dillon et al.   MOLECULAR CANCER THERAPEUTICS

PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells

(2016) Shuhei Ito et al.   PLoS One

Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation

(2015) Narasimharao Nalabothula et al.   PLoS One

Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells

(2014) Aki Miyasaka et al.   BMC CANCER

Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes

(2014) Corine M. Beaufort et al.   PLoS One

A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance

(2014) Simran Khurana et al.   Cell Reports

Activation of DNA Damage Response Signaling by Condensed Chromatin

(2014) Rebecca C. Burgess et al.   Cell Reports

ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status

(2013) C. J. Huntoon et al.   CANCER RESEARCH

Checkpoint kinase 1 in DNA damage response and cell cycle regulation

(2013) Mallikarjun Patil et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776

(2013) C. G. Engelke et al.   CLINICAL CANCER RESEARCH

Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice

(2013) Thomas Helleday   CURRENT OPINION IN ONCOLOGY

Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond

(2013) Lidiya Luzhna et al.   Frontiers in Genetics

Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B

(2012) Aneta Rogalska et al.   TOXICOLOGY IN VITRO

Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements

(2011) Dorota Rybaczek et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The roles of PARP1 in gene control and cell differentiation

(2010) Yingbiao Ji et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage

(2010) Godelieve Smeenk et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions

(2008) E. Soutoglou et al.   SCIENCE