The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells
出版年份 2022 全文链接
标题
The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCAMUT and BRCAWT Ovarian Cancer Cells
作者
关键词
-
出版物
Cells
Volume 11, Issue 12, Pages 1889
出版商
MDPI AG
发表日期
2022-06-10
DOI
10.3390/cells11121889
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Studying PAR-Dependent Chromatin Remodeling to Tackle PARPi Resistance
- (2021) Christina Andronikou et al. TRENDS IN MOLECULAR MEDICINE
- Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines
- (2021) Patrycja Gralewska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Olaparib: A Review as First-Line Maintenance Therapy in Advanced Ovarian Cancer
- (2021) Julia Paik Targeted Oncology
- Update on Poly ADP-Ribose Polymerase Inhibitors in Ovarian Cancer With Non-BRCA Mutations
- (2021) Qin Xu et al. Frontiers in Pharmacology
- Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
- (2020) Rebecca L. Lloyd et al. ONCOGENE
- Chemical modification of melphalan as a key to improving treatment of haematological malignancies
- (2020) Arkadiusz Gajek et al. Scientific Reports
- ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms
- (2020) Harriet E. D. Southgate et al. Cancers
- Ovarian Cancer, Cancer Stem Cells and Current Treatment Strategies: A Potential Role of Magmas in the Current Treatment Methods
- (2020) Nuzhat Ahmed et al. Cells
- Identifying and Overcoming Mechanisms of PARP Inhibitor Resistance in Homologous Recombination Repair-Deficient and Repair-Proficient High Grade Serous Ovarian Cancer Cells
- (2020) Miriam K. Gomez et al. Cancers
- Efficacy and Prognostic Factors for PARP Inhibitors in Patients With Ovarian Cancer
- (2020) Xuan-zhang Huang et al. Frontiers in Oncology
- PARP Inhibition Increases the Reliance on ATR/CHK1 Checkpoint Signaling Leading to Synthetic Lethality—An Alternative Treatment Strategy for Epithelial Ovarian Cancer Cells Independent from HR Effectiveness
- (2020) Patrycja Gralewska et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Suppression of autophagy enhances preferential toxicity of Epothilone A and Epothilone B in ovarian cancer cells
- (2019) Aneta Rogalska et al. PHYTOMEDICINE
- Mitotic functions of poly(ADP-ribose) polymerases
- (2019) Dea Slade BIOCHEMICAL PHARMACOLOGY
- Differential activity of ATR and WEE1 inhibitors in a highly sensitive subpopulation of DLBCL linked to replication stress
- (2019) Lucy A. Young et al. CANCER RESEARCH
- Exploiting interconnected synthetic lethal interactions between PARP inhibition and cancer cell reversible senescence
- (2019) Hubert Fleury et al. Nature Communications
- Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling and cytotoxicity in BRCA2‐deficient cancer cells
- (2019) Pepijn M. Schoonen et al. Molecular Oncology
- Low-Dose and Long-Term Olaparib Treatment Sensitizes MDA-MB-231 and SUM1315 Triple-Negative Breast Cancers Spheroids to Fractioned Radiotherapy
- (2019) Clémence Dubois et al. Journal of Clinical Medicine
- Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib
- (2018) Polly Gravells et al. DNA REPAIR
- Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
- (2018) Jone Michelena et al. Nature Communications
- An intrinsic S/G2 checkpoint enforced by ATR
- (2018) Joshua C. Saldivar et al. SCIENCE
- Homologous recombination deficiency in ovarian cancer: a review of its epidemiology and management
- (2018) RR Bonadio et al. Clinics
- The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
- (2017) Arnab Ray Chaudhuri et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma
- (2017) V Colicchia et al. ONCOGENE
- Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
- (2017) Pepijn M. Schoonen et al. Nature Communications
- PARP inhibition causes premature loss of cohesion in cancer cells
- (2017) Eva Kukolj et al. Oncotarget
- The G2 checkpoint-a node-based molecular switch
- (2017) Mark C. de Gooijer et al. FEBS Open Bio
- Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells
- (2016) Aneta Balcerczyk et al. BIOCHEMICAL PHARMACOLOGY
- Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models
- (2016) Hyoung Kim et al. CLINICAL CANCER RESEARCH
- Radiosensitization by the ATR Inhibitor AZD6738 through Generation of Acentric Micronuclei
- (2016) Magnus T. Dillon et al. MOLECULAR CANCER THERAPEUTICS
- PARP Inhibitors in Clinical Use Induce Genomic Instability in Normal Human Cells
- (2016) Shuhei Ito et al. PLoS One
- Genome-Wide Profiling of PARP1 Reveals an Interplay with Gene Regulatory Regions and DNA Methylation
- (2015) Narasimharao Nalabothula et al. PLoS One
- Anti-tumor activity of olaparib, a poly (ADP-ribose) polymerase (PARP) inhibitor, in cultured endometrial carcinoma cells
- (2014) Aki Miyasaka et al. BMC CANCER
- Ovarian Cancer Cell Line Panel (OCCP): Clinical Importance of In Vitro Morphological Subtypes
- (2014) Corine M. Beaufort et al. PLoS One
- A Macrohistone Variant Links Dynamic Chromatin Compaction to BRCA1-Dependent Genome Maintenance
- (2014) Simran Khurana et al. Cell Reports
- Activation of DNA Damage Response Signaling by Condensed Chromatin
- (2014) Rebecca C. Burgess et al. Cell Reports
- ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
- (2013) C. J. Huntoon et al. CANCER RESEARCH
- Checkpoint kinase 1 in DNA damage response and cell cycle regulation
- (2013) Mallikarjun Patil et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776
- (2013) C. G. Engelke et al. CLINICAL CANCER RESEARCH
- Putting poly (ADP-ribose) polymerase and other DNA repair inhibitors into clinical practice
- (2013) Thomas Helleday CURRENT OPINION IN ONCOLOGY
- Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond
- (2013) Lidiya Luzhna et al. Frontiers in Genetics
- Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B
- (2012) Aneta Rogalska et al. TOXICOLOGY IN VITRO
- Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements
- (2011) Dorota Rybaczek et al. HISTOCHEMISTRY AND CELL BIOLOGY
- The roles of PARP1 in gene control and cell differentiation
- (2010) Yingbiao Ji et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage
- (2010) Godelieve Smeenk et al. JOURNAL OF CELL BIOLOGY
- Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers
- (2009) Peter C. Fong et al. NEW ENGLAND JOURNAL OF MEDICINE
- Death through a tragedy: mitotic catastrophe
- (2008) H Vakifahmetoglu et al. CELL DEATH AND DIFFERENTIATION
- Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
- (2008) E. Soutoglou et al. SCIENCE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started