Role of Hepatocyte Senescence in the Activation of Hepatic Stellate Cells and Liver Fibrosis Progression

Onset of Senescence and Steatosis in Hepatocytes as a Consequence of a Shift in the Diacylglycerol/Ceramide Balance at the Plasma Membrane

(2021) Gergana Deevska et al.   Cells

A proteomic atlas of senescence-associated secretomes for aging biomarker development

(2020) Nathan Basisty et al.   PLOS BIOLOGY

RNA sequencing reveals changes in the microRNAome of transdifferentiating hepatic stellate cells that are conserved between human and rat

(2020) Laura Sabater et al.   Scientific Reports

Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging

(2019) Eunhui Seo et al.   AGING CELL

Hallmarks of Cellular Senescence

(2018) Alejandra Hernandez-Segura et al.   TRENDS IN CELL BIOLOGY

Biomarkers of Cellular Senescence and Skin Aging

(2018) Audrey S. Wang et al.   Frontiers in Genetics

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/− ) mice

(2017) Anja Moncsek et al.   HEPATOLOGY

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Selective insulin resistance in hepatocyte senescence

(2015) Aloysious Aravinthan et al.   EXPERIMENTAL CELL RESEARCH

Hepatocyte senescence explains conjugated bilirubinaemia in chronic liver failure

(2015) Aloysious D. Aravinthan et al.   JOURNAL OF HEPATOLOGY

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Cellular senescence: a hitchhiker’s guide

(2015) Aloysious Aravinthan   Human Cell

Unleashing rapamycin in fibrosis

(2015) Alexander T. Hillel et al.   Oncotarget

Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis

(2015) Chad McKee et al.   Scientific Reports

A retrospective 15-year review: survival advantage after switching to sirolimus in hepatitis C virus infected liver graft recipients

(2014) M. Shah et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The senescent hepatocyte gene signature in chronic liver disease

(2014) Aloysious Aravinthan et al.   EXPERIMENTAL GERONTOLOGY

Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2

(2014) Weijie Wang et al.   PLoS One

Analyzing huge pathology images with open source software

(2013) Christophe Deroulers et al.   Diagnostic Pathology

Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease

(2013) Aloysious Aravinthan et al.   PLoS One

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Autophagy in cancer: Having your cake and eating it

(2011) Matthew Hoare et al.   SEMINARS IN CANCER BIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS