Cellular senescence: a hitchhiker’s guide

Adult-onset, short-term dietary restriction reduces cell senescence in mice

(2016) Chunfang Wang et al.   Aging-US

Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling

(2016) H. Dorota Halicka et al.   Aging-US

Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling

(2016) H. Dorota Halicka et al.   Aging-US

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

(2014) Florence C. C. Tan et al.   BIOGERONTOLOGY

The senescent hepatocyte gene signature in chronic liver disease

(2014) Aloysious Aravinthan et al.   EXPERIMENTAL GERONTOLOGY

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Cellular senescence or EGFR signaling induces Interleukin 6 (IL-6) receptor expression controlled by mammalian target of rapamycin (mTOR)

(2013) Christoph Garbers et al.   CELL CYCLE

Dual CDK4/CDK6 Inhibition Induces Cell-Cycle Arrest and Senescence in Neuroblastoma

(2013) J. Rader et al.   CLINICAL CANCER RESEARCH

The Length of the Shortest Telomere as the Major Determinant of the Onset of Replicative Senescence

(2013) Zhou Xu et al.   GENETICS

Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell

(2013) Hyun-Jin Na et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Hepatocyte Expression of the Senescence Marker p21 Is Linked to Fibrosis and an Adverse Liver-Related Outcome in Alcohol-Related Liver Disease

(2013) Aloysious Aravinthan et al.   PLoS One

Senescent Cardiac Fibroblast Is Critical for Cardiac Fibrosis after Myocardial Infarction

(2013) Fuli Zhu et al.   PLoS One

Cellular senescence in normal and premature lung aging

(2013) B. Bartling   ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE

Regulation of senescence by microRNA biogenesis factors

(2012) Kotb Abdelmohsen et al.   AGEING RESEARCH REVIEWS

A senescent cell bystander effect: senescence-induced senescence

(2012) Glyn Nelson et al.   AGING CELL

Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD

(2012) Young C. Jang et al.   AGING CELL

Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

(2012) Vladimir N. Anisimov et al.   CELL CYCLE

MicroRNAs and their roles in aging

(2012) T. Smith-Vikos et al.   JOURNAL OF CELL SCIENCE

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

Microarray-based identification of age-dependent differences in gene expression of human dermal fibroblasts

(2012) Pim Dekker et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

(2011) Antero Salminen et al.   CELLULAR SIGNALLING

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Proteomic and metabolomic analysis of H2O2-induced premature senescent human mesenchymal stem cells

(2011) Ji-Soo Kim et al.   EXPERIMENTAL GERONTOLOGY

Ginsenoside Rb1 Reverses H2O2-induced Senescence in Human Umbilical Endothelial Cells

(2011) Ding-Hui Liu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

(2011) M. Narita et al.   SCIENCE

Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy

(2011) Jun Liu et al.   Translational Research

MicroRegulators come of age in senescence

(2011) Myriam Gorospe et al.   TRENDS IN GENETICS

Impact of cellular senescence signature on ageing research

(2010) Ewa Sikora et al.   AGEING RESEARCH REVIEWS

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Oxidative Damage Increases and Antioxidant Gene Expression Decreases with Aging in the Mouse Ovary

(2010) J. Lim et al.   BIOLOGY OF REPRODUCTION

Senescent cells as a source of inflammatory factors for tumor progression

(2010) Albert R. Davalos et al.   CANCER AND METASTASIS REVIEWS

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

(2010) Richard A. Miller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

DNA damage response and cellular senescence in tissues of aging mice

(2009) Chunfang Wang et al.   AGING CELL

Autophagy mediates the mitotic senescence transition

(2009) A. R.J. Young et al.   GENES & DEVELOPMENT

Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging

(2009) Li Zhuo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Alterations in microRNA expression in stress-induced cellular senescence

(2009) Guorong Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7

(2008) Narendra Wajapeyee et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Critical pathways in cellular senescence and immortalization revealed by gene expression profiling

(2008) A L Fridman et al.   ONCOGENE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY