DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway

M6A demethylase FTO-mediated downregulation of DACT1 mRNA stability promotes Wnt signaling to facilitate osteosarcoma progression

(2022) Dongming Lv et al.   ONCOGENE

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex

(2021) Jalila Chagraoui et al.   Cell Stem Cell

Chemotherapy in Combination With Radiotherapy for Definitive-Intent Treatment of Stage II-IVA Nasopharyngeal Carcinoma: CSCO and ASCO Guideline

(2021) Yu-Pei Chen et al.   JOURNAL OF CLINICAL ONCOLOGY

HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target

(2021) Chun Cheng et al.   Cell Death & Disease

Frequent amplification of HDAC genes and efficacy of HDAC inhibitor chidamide and PD-1 blockade combination in soft tissue sarcoma

(2021) Yi Que et al.   Journal for ImmunoTherapy of Cancer

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

(2021) Bas Ponsioen et al.   NATURE CELL BIOLOGY

Combination of Chidamide-Mediated Epigenetic Modulation with Immunotherapy: Boosting Tumor Immunogenicity and Response to PD-1/PD-L1 Blockade

(2021) Kun Tu et al.   ACS Applied Materials & Interfaces

Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival

(2021) Paolo Armando Gagliardi et al.   DEVELOPMENTAL CELL

Gemcitabine Plus Cisplatin Versus Fluorouracil Plus Cisplatin as First-Line Therapy for Recurrent or Metastatic Nasopharyngeal Carcinoma: Final Overall Survival Analysis of GEM20110714 Phase III Study

(2021) Shaodong Hong et al.   JOURNAL OF CLINICAL ONCOLOGY

Camrelizumab versus placebo in combination with gemcitabine and cisplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (CAPTAIN-1st): a multicentre, randomised, double-blind, phase 3 trial

(2021) Yunpeng Yang et al.   LANCET ONCOLOGY

Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor

(2021) Chu-An Wang et al.   MOLECULAR CANCER THERAPEUTICS

TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination

(2021) Guixin Zhu et al.   NATURE CELL BIOLOGY

Toripalimab or placebo plus chemotherapy as first-line treatment in advanced nasopharyngeal carcinoma: a multicenter randomized phase 3 trial

(2021) Hai-Qiang Mai et al.   NATURE MEDICINE

Nasopharyngeal carcinoma: an evolving paradigm

(2021) Kenneth C. W. Wong et al.   Nature Reviews Clinical Oncology

HDAC1 is required for GATA-1 transcription activity, global chromatin occupancy and hematopoiesis

(2021) Bowen Yan et al.   NUCLEIC ACIDS RESEARCH

EBF3 reactivation by inhibiting the EGR1/EZH2/HDAC9 complex promotes metastasis via transcriptionally enhancing vimentin in nasopharyngeal carcinoma

(2021) Shirong Ding et al.   CANCER LETTERS

Structural dynamics in the evolution of a bilobed protein scaffold

(2021) Giorgos Gouridis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inner nuclear protein Matrin-3 coordinates cell differentiation by stabilizing chromatin architecture

(2021) Hye Ji Cha et al.   Nature Communications

The histone deacetylase complex MiDAC regulates a neurodevelopmental gene expression program to control neurite outgrowth

(2020) Baisakhi Mondal et al.   eLife

Microbiota-derived metabolite promotes HDAC3 activity in the gut

(2020) Shu-en Wu et al.   NATURE

Chemoradiotherapy improves NPC outcomes

(2020) Peter Sidaway   Nature Reviews Clinical Oncology

The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure

(2020) Robert E. Turnbull et al.   Nature Communications

A distal regulatory region of a class I human histone deacetylase

(2020) Nicolas D. Werbeck et al.   Nature Communications

Chidamide increases the sensitivity of refractory or relapsed acute myeloid leukemia cells to anthracyclines via regulation of the HDAC3 -AKT-P21-CDK2 signaling pathway

(2020) Hao Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Anti-Tumor T-cell Immunity

(2020) Aayoung Hong et al.   Cancer Discovery

Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial

(2019) Zefei Jiang et al.   LANCET ONCOLOGY

Nasopharyngeal carcinoma treated with intensity-modulated radiotherapy: clinical outcomes and patterns of failure among subsets of 8th AJCC stage IVa

(2019) Cheng-Long Huang et al.   EUROPEAN RADIOLOGY

Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer

(2018) Yuki Sawai et al.   LABORATORY INVESTIGATION

Gemcitabine plus cisplatin versus fluorouracil plus cisplatin in recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase 3 trial

(2016) Li Zhang et al.   LANCET

Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma

(2015) Y. Shi et al.   ANNALS OF ONCOLOGY

Inhibition of class I histone deacetylases by romidepsin potently induces Epstein-Barr virus lytic cycle and mediates enhanced cell death with ganciclovir

(2015) Kwai Fung Hui et al.   INTERNATIONAL JOURNAL OF CANCER

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting

(2015) Toshimasa Itoh et al.   NUCLEIC ACIDS RESEARCH

Combination of proteasome and class I HDAC inhibitors induces apoptosis of NPC cells through an HDAC6-independent ER stress-induced mechanism

(2014) Kwai Fung Hui et al.   INTERNATIONAL JOURNAL OF CANCER

Treatment of Nasopharyngeal Carcinoma Cells with the Histone-Deacetylase Inhibitor Abexinostat: Cooperative Effects with Cis-platin and Radiotherapy on Patient-Derived Xenografts

(2014) Mélanie Gressette et al.   PLoS One

Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma

(2012) K.F. Hui et al.   INTERNATIONAL JOURNAL OF CANCER

Quantitative Proteomics Reveals the Basis for the Biochemical Specificity of the Cell-Cycle Machinery

(2011) Felicia Walton Pagliuca et al.   MOLECULAR CELL

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm

(2009) Takahide Hayano et al.   GENES TO CELLS

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

(2008) Stephen M. Keyse   CANCER AND METASTASIS REVIEWS