Disruption of the circadian clock drives Apc loss of heterozygosity to accelerate colorectal cancer

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

(2021) Ayesha A. Shafi et al.   Nature Communications

CRY2 missense mutations suppress P53 and enhance cell growth

(2021) Alanna B. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucagon regulates the stability of REV-ERBα to modulate hepatic glucose production in a model of lung cancer–associated cachexia

(2021) Amandine Verlande et al.   Science Advances

The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.

(2021) Kyle Stokes et al.   Cellular and Molecular Gastroenterology and Hepatology

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

Type V Collagen in Scar Tissue Regulates the Size of Scar after Heart Injury

(2020) Tomohiro Yokota et al.   CELL

Lineage reversion drives WNT independence in intestinal cancer

(2020) Teng Han et al.   Cancer Discovery

Circadian regulation of c-MYC in mice

(2020) Zhenxing Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt

(2020) Amber N. Habowski et al.   Communications Biology

Development and validation of a 4-color multiplexing spinal muscular atrophy (SMA) genotyping assay on a novel integrated digital PCR instrument

(2020) Lingxia Jiang et al.   Scientific Reports

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism

(2019) Gisela Geoghegan et al.   Molecular Metabolism

High-fructose corn syrup enhances intestinal tumor growth in mice

(2019) Marcus D. Goncalves et al.   SCIENCE

FXR Regulates Intestinal Cancer Stem Cell Proliferation

(2019) Ting Fu et al.   CELL

Metabolic pathways regulating colorectal cancer initiation and progression

(2019) Sofia La Vecchia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism

(2019) Amandine Verlande et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Genomics of circadian rhythms in health and disease

(2019) Filipa Rijo-Ferreira et al.   Genome Medicine

Topological Arrangement of Cardiac Fibroblasts Regulates Cellular PlasticityNovelty and Significance

(2018) Jingyi Yu et al.   CIRCULATION RESEARCH

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes

(2018) Dongyin Guan et al.   CELL

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

(2018) Amandine Chaix et al.   Cell Metabolism

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

(2018) Baharan Fekry et al.   Nature Communications

Intestinal Stem Cells Exhibit Conditional Circadian Clock Function

(2018) Kathyani Parasram et al.   Stem Cell Reports

Colorectal Cancer Mortality Rates in Adults Aged 20 to 54 Years in the United States, 1970-2014

(2017) Rebecca L. Siegel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

Colorectal Cancer Incidence Patterns in the United States, 1974–2013

(2017) Rebecca L. Siegel et al.   JNCI-Journal of the National Cancer Institute

Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer

(2017) Lu Zhang et al.   JNCI-Journal of the National Cancer Institute

c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level

(2016) Anastasia Repouskou et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene

(2016) Peter Zauber et al.   BMC CANCER

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Lung Adenocarcinoma Distally Rewires Hepatic Circadian Homeostasis

(2016) Selma Masri et al.   CELL

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

(2016) Shawn M. Davidson et al.   Cell Metabolism

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

(2016) Aaron M. Hosios et al.   DEVELOPMENTAL CELL

Deregulated expression of cryptochrome genes in human colorectal cancer

(2016) Gianluigi Mazzoccoli et al.   Molecular Cancer

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Intercellular Coupling of the Cell Cycle and Circadian Clock in Adult Stem Cell Culture

(2016) Toru Matsu-ura et al.   MOLECULAR CELL

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

Circadian time signatures of fitness and disease

(2016) Joseph Bass et al.   SCIENCE

MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation

(2016) Anton Shostak et al.   Nature Communications

Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

(2015) Lukas E. Dow et al.   CELL

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

Sequential cancer mutations in cultured human intestinal stem cells

(2015) Jarno Drost et al.   NATURE

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Increasing Disparities in the Age-Related Incidences of Colon and Rectal Cancers in the United States, 1975-2010

(2015) Christina E. Bailey et al.   JAMA Surgery

Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges

(2014) Amandine Chaix et al.   Cell Metabolism

Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer

(2014) K. T. Pate et al.   EMBO JOURNAL

The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

(2014) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Glutamine Oxidation Maintains the TCA Cycle and Cell Survival during Impaired Mitochondrial Pyruvate Transport

(2014) Chendong Yang et al.   MOLECULAR CELL

The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition

(2014) Nate P. Hoverter et al.   NUCLEIC ACIDS RESEARCH

Strengths and Limitations of Period Estimation Methods for Circadian Data

(2014) Tomasz Zielinski et al.   PLoS One

Transcriptional program of Kpna2/Importin-α2 regulates cellular differentiation-coupled circadian clock development in mammalian cells

(2014) Yasuhiro Umemura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming of the Circadian Clock by Nutritional Challenge

(2013) Kristin L. Eckel-Mahan et al.   CELL

The Development of Highly Potent Inhibitors for Porcupine

(2013) Xiaolei Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Circadian Clock Gates the Intestinal Stem Cell Regenerative State

(2013) Phillip Karpowicz et al.   Cell Reports

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Effect of circadian clock mutations on DNA damage response in mammalian cells

(2012) Shobhan Gaddameedhi et al.   CELL CYCLE

Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

(2012) Megumi Hatori et al.   Cell Metabolism

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

Metabolic trajectory of cellular differentiation in small intestine by Phasor Fluorescence Lifetime Microscopy of NADH

(2012) Chiara Stringari et al.   Scientific Reports

Clock Gene Expression Levels and Relationship With Clinical and Pathological Features in Colorectal Cancer Patients

(2011) G. Mazzoccoli et al.   CHRONOBIOLOGY INTERNATIONAL

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

(2010) Michael E. Hughes et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Regulation of nucleotide excision repair activity by transcriptional and post-transcriptional control of the XPA protein

(2010) T.-H. Kang et al.   NUCLEIC ACIDS RESEARCH

Identification of β-catenin binding regions in colon cancer cells using ChIP-Seq

(2010) Daniel Bottomly et al.   NUCLEIC ACIDS RESEARCH

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Complete deletion of Apc results in severe polyposis in mice

(2009) A F Cheung et al.   ONCOGENE

WGCNA: an R package for weighted correlation network analysis

(2008) Peter Langfelder et al.   BMC BIOINFORMATICS

A Genome-Wide Screen for  -Catenin Binding Sites Identifies a Downstream Enhancer Element That Controls c-Myc Gene Expression

(2008) G. S. Yochum et al.   MOLECULAR AND CELLULAR BIOLOGY

R-Spondin Family Members Regulate the Wnt Pathway by a Common Mechanism

(2008) Kyung-Ah Kim et al.   MOLECULAR BIOLOGY OF THE CELL

Period 2 Mutation Accelerates ApcMin/+ Tumorigenesis

(2008) P. A. Wood et al.   MOLECULAR CANCER RESEARCH

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Phasor Approach to Fluorescence Lifetime Imaging Analysis

(2007) Michelle A. Digman et al.   BIOPHYSICAL JOURNAL