CRY2 missense mutations suppress P53 and enhance cell growth

Cryptochromes modulate E2F family transcription factors

(2020) Alanna B. Chan et al.   Scientific Reports

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing

(2020) Jennifer L Fribourgh et al.   eLife

Cancer, hear my battle CRY

(2020) Alanna B. Chan et al.   JOURNAL OF PINEAL RESEARCH

The mutational constraint spectrum quantified from variation in 141,456 humans

(2020) Konrad J. Karczewski et al.   NATURE

Isoform-selective regulation of mammalian cryptochromes

(2020) Simon Miller et al.   Nature Chemical Biology

Cryptochromes Suppress HIF1α in Muscles

(2020) Megan E. Vaughan et al.   iScience

Cancer in the Fourth Dimension: What Is the Impact of Circadian Disruption?

(2020) Marie Pariollaud et al.   Cancer Discovery

The circadian E3 ligase complex SCFFBXL3+CRY targets TLK2

(2019) Stephanie Papp Correia et al.   Scientific Reports

Targeting Glioblastoma Stem Cells through Disruption of the Circadian Clock

(2019) Zhen Dong et al.   Cancer Discovery

Advances in Hypoxia-Inducible Factor Biology

(2018) Hani Choudhry et al.   Cell Metabolism

An evolutionary hotspot defines functional differences between CRYPTOCHROMES

(2018) Clark Rosensweig et al.   Nature Communications

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

Critical cholangiocarcinogenesis control by cryptochrome clock genes

(2017) Ali Mteyrek et al.   INTERNATIONAL JOURNAL OF CANCER

Macromolecular Assemblies of the Mammalian Circadian Clock

(2017) Rajindra P. Aryal et al.   MOLECULAR CELL

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity

(2017) Anna Kriebs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembly and function of bHLH–PAS complexes

(2017) Jennifer L. Fribourgh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1

(2017) Alicia K. Michael et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

(2016) Nicole M. Kettner et al.   CANCER CELL

Hypoxia‐inducible factors: coupling glucose metabolism and redox regulation with induction of the breast cancer stem cell phenotype

(2016) Gregg L Semenza   EMBO JOURNAL

CRY2 and FBXL3 Cooperatively Degrade c-MYC

(2016) Anne-Laure Huber et al.   MOLECULAR CELL

Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

(2016) Tetsuya Gotoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding

(2016) Hagoon Jang et al.   Nature Communications

Clock gene Per2 as a controller of liver carcinogenesis

(2016) Ali Mteyrek et al.   Oncotarget

CH Activation Generates Period-Shortening Molecules That Target Cryptochrome in the Mammalian Circadian Clock

(2015) Tsuyoshi Oshima et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Small-Molecule Cryptochrome Stabilizer Derivatives as Modulators of the Circadian Clock

(2015) Jae Wook Lee et al.   ChemMedChem

Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signaling

(2015) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus

(2015) Haiyan Xu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization

(2015) Stephanie J Papp et al.   eLife

The Molecular Signatures Database Hallmark Gene Set Collection

(2015) Arthur Liberzon et al.   Cell Systems

Emerging Models for the Molecular Basis of Mammalian Circadian Timing

(2014) Chelsea L. Gustafson et al.   BIOCHEMISTRY

Interaction of Circadian Clock Proteins CRY1 and PER2 Is Modulated by Zinc Binding and Disulfide Bond Formation

(2014) Ira Schmalen et al.   CELL

Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock

(2014) Rui Ye et al.   GENES & DEVELOPMENT

The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cells

(2014) Tetsuya Gotoh et al.   MOLECULAR BIOLOGY OF THE CELL

Robust synchronization of coupled circadian and cell cycle oscillators in single mammalian cells

(2014) J. Bieler et al.   Molecular Systems Biology

Circadian rhythms synchronize mitosis in Neurospora crassa

(2014) C. I. Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular assembly of the period-cryptochrome circadian transcriptional repressor complex

(2014) Shannon N Nangle et al.   eLife

Competing E3 Ubiquitin Ligases Govern Circadian Periodicity by Degradation of CRY in Nucleus and Cytoplasm

(2013) Seung-Hee Yoo et al.   CELL

FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of Cryptochromes

(2013) Arisa Hirano et al.   CELL

Deficiency in PER proteins has no effect on the rate of spontaneous and radiation-induced carcinogenesis

(2013) Marina P Antoch et al.   CELL CYCLE

Phosphorylation of the Cryptochrome 1 C-terminal Tail Regulates Circadian Period Length

(2013) Peng Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket

(2013) Weiman Xing et al.   NATURE

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

(2013) W. W. Hwang-Verslues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Circadian topology of metabolism

(2012) Joseph Bass   NATURE

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

(2012) M. Geyfman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NONO couples the circadian clock to the cell cycle

(2012) E. Kowalska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Small Molecule Activators of Cryptochrome

(2012) T. Hirota et al.   SCIENCE

Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

(2012) N. Koike et al.   SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Delay in Feedback Repression by Cryptochrome 1 Is Required for Circadian Clock Function

(2011) Maki Ukai-Tadenuma et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The circadian mutation PER2 S662G is linked to cell cycle progression and tumorigenesis

(2011) X Gu et al.   CELL DEATH AND DIFFERENTIATION

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

(2011) Katja A. Lamia et al.   NATURE

Phenotypic effects of the circadian gene Cryptochrome 2 on cancer-related pathways

(2010) Aaron E Hoffman et al.   BMC CANCER

DYRK1A and Glycogen Synthase Kinase 3 , a Dual-Kinase Mechanism Directing Proteasomal Degradation of CRY2 for Circadian Timekeeping

(2010) N. Kurabayashi et al.   MOLECULAR AND CELLULAR BIOLOGY

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

(2010) Susie Lee et al.   PLoS One

Generation of a Novel Allelic Series of Cryptochrome Mutants via Mutagenesis Reveals Residues Involved in Protein-Protein Interaction and CRY2-Specific Repression

(2009) E. V. McCarthy et al.   MOLECULAR AND CELLULAR BIOLOGY

Per2 Inhibits K562 Leukemia Cell Growth In Vitro and In Vivo Through Cell Cycle Arrest and Apoptosis Induction

(2009) Cheng-ming Sun et al.   PATHOLOGY & ONCOLOGY RESEARCH

Loss of cryptochrome reduces cancer risk inp53mutant mice

(2009) Nuri Ozturk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Implication of the F-Box Protein FBXL21 in Circadian Pacemaker Function in Mammals

(2008) Hugues Dardente et al.   PLoS One