TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells

(2022) Helga Simon-Molas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The E3 ubiquitin ligase TRIM31 is involved in cerebral ischemic injury by promoting degradation of TIGAR

(2021) Shenglan Zeng et al.   Redox Biology

NADPH protects against kainic acid-induced excitotoxicity via autophagy-lysosome pathway in rat striatum and primary cortical neurons

(2020) Zi-Qi Liu et al.   TOXICOLOGY

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

(2020) Xiaoli Wu et al.   Autophagy

Selective autophagy as a therapeutic target for neurological diseases

(2020) Weilin Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Somatic autophagy of axonal mitochondria in ischemic neurons

(2019) Yanrong Zheng et al.   JOURNAL OF CELL BIOLOGY

Glucose-6-phosphate dehydrogenase blockade potentiates tyrosine kinase inhibitor effect on breast cancer cells through autophagy perturbation

(2019) Luigi Mele et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

(2019) Wenjuan Zhou et al.   Frontiers in Molecular Neuroscience

Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice

(2019) Olga Burmistrova et al.   Scientific Reports

13 reasons why the brain is susceptible to oxidative stress

(2018) James Nathan Cobley et al.   Redox Biology

G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway

(2017) Lijuan Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors

(2016) Anju Singh et al.   ACS Chemical Biology

Nrf2—a Promising Therapeutic Target for Defensing Against Oxidative Stress in Stroke

(2016) Rongrong Zhang et al.   MOLECULAR NEUROBIOLOGY

Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation

(2015) Jeong Su Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke

(2015) Mei Li et al.   STROKE

The glycolytic enzyme PFKFB3/phosphofructokinase regulates autophagy

(2014) Zhen Yang et al.   Autophagy

A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

(2014) M. Li et al.   JOURNAL OF NEUROSCIENCE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells

(2013) Ling Ye et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

(2013) Balaraman Kalyanaraman   Redox Biology

Mitochondrial Thiols in the Regulation of Cell Death Pathways

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Sestrins Activate Nrf2 by Promoting p62-Dependent Autophagic Degradation of Keap1 and Prevent Oxidative Liver Damage

(2012) Soo Han Bae et al.   Cell Metabolism

Expression of Keap1–Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion

(2010) Nobuhito Tanaka et al.   BRAIN RESEARCH

Regulation of autophagy by ROS: physiology and pathology

(2010) Ruth Scherz-Shouval et al.   TRENDS IN BIOCHEMICAL SCIENCES

Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia

(2009) Chenhui Yang et al.   BRAIN RESEARCH

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY