N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ciclopirox activates PERK-dependent endoplasmic reticulum stress to drive cell death in colorectal cancer

(2020) Jianjun Qi et al.   Cell Death & Disease

MERTK tyrosine kinase receptor together with TIM4 phosphatidylserine receptor mediates distinct signal transduction pathways for efferocytosis and cell proliferation

(2019) Chihiro Nishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease

(2019) Mirella Pastore et al.   Frontiers in Pharmacology

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis

(2019) Bishuang Cai et al.   Cell Metabolism

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

MERTK mediates intrinsic and adaptive resistance to AXL-targeting agents

(2018) Nellie K McDaniel et al.   MOLECULAR CANCER THERAPEUTICS

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure

(2017) Evangelos Triantafyllou et al.   GUT

Role of N-glycosylation in EGFR ectodomain ligand binding

(2017) Maryam Azimzadeh Irani et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genetic prevention of hepatitis C virus-induced liver fibrosis by allele-specific downregulation of MERTK

(2016) Marco Cavalli et al.   HEPATOLOGY RESEARCH

MERTK rs4374383 polymorphism affects the severity of fibrosis in non-alcoholic fatty liver disease

(2016) Salvatore Petta et al.   JOURNAL OF HEPATOLOGY

Site-Specific N-Glycosylation of Endothelial Cell Receptor Tyrosine Kinase VEGFR-2

(2016) Kevin Brown Chandler et al.   JOURNAL OF PROTEOME RESEARCH

MERTK as a novel therapeutic target in head and neck cancer

(2016) Anne von Mässenhausen et al.   Oncotarget

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

(2016) Marka R. Crittenden et al.   Oncotarget

Downregulation of TFAM inhibits the tumorigenesis of non-small cell lung cancer by activating ROS-mediated JNK/p38MAPK signaling and reducing cellular bioenergetics

(2016) Deyao Xie et al.   Oncotarget

In-depthN-glycome profiling of paired colorectal cancer and non-tumorigenic tissues reveals cancer-, stage- and EGFR-specific protein N-glycosylation

(2015) Manveen K Sethi et al.   GLYCOBIOLOGY

Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition

(2015) Hsin-Yung Yen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MerTK is a novel therapeutic target in gastric cancer

(2015) Jun Ho Yi et al.   Oncotarget

Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer

(2015) Yongzhang Liu et al.   Oncotarget

Mer tyrosine kinase promotes the survival of t(1;19)-positive acute lymphoblastic leukemia (ALL) in the central nervous system (CNS)

(2014) S. Krause et al.   BLOOD

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Overexpression of MERTK Receptor Tyrosine Kinase in Epithelial Cancer Cells Drives Efferocytosis in a Gain-of-Function Capacity

(2014) Khanh-Quynh N. Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Pathways: MERTK Signaling in Cancer

(2013) C. T. Cummings et al.   CLINICAL CANCER RESEARCH

MERTK receptor tyrosine kinase is a therapeutic target in melanoma

(2013) Jennifer Schlegel et al.   JOURNAL OF CLINICAL INVESTIGATION

Axl/Gas6/NFκB signalling in schwannoma pathological proliferation, adhesion and survival

(2013) S Ammoun et al.   ONCOGENE

c-Met function requires n-linked glycosylation modification of pro-Met

(2012) Run Chen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer

(2012) R M A Linger et al.   ONCOGENE

Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus

(2012) Justine Migdall-Wilson et al.   PLoS One

Cross-Phosphorylation, Signaling and Proliferative Functions of the Tyro3 and Axl Receptors in Rat2 Cells

(2012) Jessica E. Brown et al.   PLoS One

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Recombinant Mouse Granulocyte–Macrophage Colony-Stimulating Factor Is Glycosylated in Transgenic Tobacco and Maintains its Biological Activity

(2009) Anna Góra-Sochacka et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Inhibition of N-Linked Glycosylation Disrupts Receptor Tyrosine Kinase Signaling in Tumor Cells

(2008) J. N. Contessa et al.   CANCER RESEARCH