Article
Biochemistry & Molecular Biology
M. Martins Pinto, P. Paumard, C. Bouchez, S. Ransac, S. Duvezin-Caubet, J. P. Mazata, M. Rigouleta, A. Devina
Summary: Cancer cells exhibit altered energy metabolism, with decreased respiration and increased glycolysis compared to normal cells. This phenomenon, known as the Warburg effect, suggests that cancer cells mainly rely on fermentative metabolism for ATP generation. The mechanisms and implications of this metabolic shift are still a topic of debate. Understanding how cancer cells regulate their energy metabolism pathways and how this metabolism affects cell proliferation is crucial for unraveling the mechanisms of cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2023)
Article
Gastroenterology & Hepatology
Qiaozhu Zuo, Jia He, Shu Zhang, Hui Wang, Guangzhi Jin, Haojie Jin, Zhuoan Cheng, Xuemei Tao, Chengtao Yu, Botai Li, Chen Yang, Siying Wang, Yuanyuan Lv, Fangyu Zhao, Ming Yao, Wenming Cong, Cun Wang, Wenxin Qin
Summary: The study revealed that PGC1 alpha is down-regulated in HCC, and its low expression is associated with poor prognosis, vascular invasion, and larger tumor size. PGC1 alpha inhibits HCC metastasis by regulating the WNT/beta-catenin/PDK1 axis.
Article
Cell Biology
Dongdong Yang, Haiying Liu, Yongping Cai, Kangyang Lu, Xiuying Zhong, Songge Xing, Wei Song, Yaping Zhang, Ling Ye, Xia Zhu, Ting Wang, Pinggen Zhang, Shi-Ting Li, Jiaqian Feng, Weidong Jia, Huafeng Zhang, Ping Gao
Summary: The catabolism of branched-chain amino acid (BCAA) is associated with tumorigenesis. This study reveals that BCAA catabolism is activated in liver cancer cells lacking glutamine. Enhanced BCAA catabolism leads to the production of BCAA-derived carbon and nitrogen for nucleotide synthesis, promoting cell-cycle progression and cell survival. The mechanism involves O-GlcNAcylation increasing under glutamine-deprivation conditions, stabilizing the PPM1K protein, and leading to dephosphorylation of BCKDHA and enhanced BCAA decomposition. Dephosphorylation of BCKDHA and high expression of PPM1K promote tumorigenesis and are associated with poor prognosis in hepatocellular carcinoma patients. Inhibiting BCAA and glutamine metabolism can slow down HCC growth in vivo. These findings shed light on the role of BCAA catabolism in tumorigenesis and identify pBCKDHA and PPM1K as potential targets for therapy and predictive biomarkers.
Review
Nutrition & Dietetics
Ghazaleh Shimi
Summary: This review describes the impact of various dietary regimens targeting the Warburg effect on cancer treatment. The evidence suggests that combining diet-based strategies with routine cancer therapies may improve treatment outcomes, but the most suitable dietary strategies for specific cancers are not well understood yet.
Article
Medicine, Research & Experimental
Guoshu Bi, Yunyi Bian, Jiaqi Liang, Jiacheng Yin, Runmei Li, Mengnan Zhao, Yiwei Huang, Tao Lu, Cheng Zhan, Hong Fan, Qun Wang
Summary: This study analyzed the metabolic characteristics of glycolysis and oxidative phosphorylation in 9668 patients across 33 tumor types, identifying four metabolic subtypes. Patients with high glycolysis and low oxidative phosphorylation were consistently associated with worse prognosis. Common dysregulated molecular features were found between different metabolic subgroups, with their mutual interfering relationships investigated.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Ying Zhang, Wenhuan Li, Yuan Bian, Yan Li, Lei Cong
Summary: Liver cancer, a common and deadly malignancy, is closely associated with changes in liver metabolism and mitochondrial dysfunction. While defects in mitochondrial respiration are not generally responsible for aerobic glycolysis or selected during tumor evolution, dysfunction of mitochondrial oxidative phosphorylation (OXPHOS) may promote the proliferation, metastasis, and invasion of primary hepatic carcinoma. This review explores the roles of aerobic glycolysis and OXPHOS in the occurrence and development of hepatocellular carcinoma (HCC), highlighting the cooperative nature of mitochondrial OXPHOS and cytoplasmic glycolysis in maintaining energy balance in HCC cells. The findings suggest that targeting mitochondrial metabolism could be a potential therapy for HCC.
Article
Immunology
Rosaria Maria Pipitone, Vincenza Calvaruso, Lorenza Di Marco, Francesca Di Salvo, Miriam Gaggianesi, Giulia Lupo, Rossella Zito, Claudia La Mantia, Matteo Ramazzotti, Salvatore Petta, Vito Di Marco, Antonio Craxi, Stefania Grimaudo
Summary: A study found that MERTK gene polymorphisms are associated with liver disease progression in patients with chronic hepatitis C, potentially influencing fibrosis and hepatocellular carcinoma development. By evaluating the expression of relevant genes, differential expression was observed in certain genes among CHC patients with different MERTK genotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Qing Peng, Liyuan Hao, Yinglin Guo, Zhiqin Zhang, Jingmin Ji, Yu Xue, Yiwei Liu, Caige Li, Junlan Lu, Xinli Shi
Summary: Hepatocellular carcinoma (HCC) is the third most common cause of cancer death, with limited therapeutic options and low survival rate. Dihydroartemisinin (DHA), an FDA-approved anti-malarial drug, inhibits cell growth in HCC. This study investigates the role of DHA in the SLC2A1 mediated Warburg effect in HCC. The findings suggest that DHA suppresses the Warburg effect and SLC2A1 expression by inhibiting YAP1 and reduces the development of HCC.
JOURNAL OF NATURAL MEDICINES
(2023)
Article
Oncology
Jun Zheng, Xijing Yan, Tongyu Lu, Wen Song, Yang Li, Jinliang Liang, Jiebin Zhang, Jianye Cai, Xin Sui, Jiaqi Xiao, Haitian Chen, Guihua Chen, Qi Zhang, Yubin Liu, Yang Yang, Kanghong Zheng, Zihao Pan
Summary: CircFOXK2 is upregulated in hepatocellular carcinoma (HCC) and is associated with poor clinical outcomes. Silencing of circFOXK2 suppresses HCC progression by regulating the expression of proteins and miRNA sponges that lead to the activation of the Warburg effect. CircFOXK2 has potential as a therapeutic target for HCC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Da Man, Yifan Jiang, Deguo Zhang, Jingjing Wu, Bo Ding, Hanqing Liu, Guangming Xu, Jiahua Lu, Junnan Ru, Rongliang Tong, Shusheng Zheng, Diyu Chen, Jian Wu
Summary: Hepatocellular carcinoma (HCC) is a lethal tumor type. This study investigated the glycosylation status of HCC and its molecular mechanisms. High glycosylation levels were found to correlate with tumor progression and poor prognosis. The key molecular mechanism involved ST6GALNAC4, which induced abnormal glycosylation and contributed to proliferation, migration, and invasion in HCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Jiawei Rao, Xukun Wu, Xiaozhuan Zhou, Ronghai Deng, Yi Ma
Summary: This study developed and validated a prognostic model for HCC by analyzing genes involved in aerobic respiration. Patients in the low-risk group showed better survival rates. This model may aid in developing personalized treatment plans for patients with HCC.
Review
Biochemistry & Molecular Biology
Yifei Wang, Huarong Chen
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths globally. Protein glycosylation, a common post-translational modification, plays a crucial role in regulating various biological processes and is implicated in the development of HCC. Aberrant protein glycosylation in hepatocytes contributes to the malignant transformation to HCC by modulating tumor-promoting signaling pathways. Changes in protein glycosylation could serve as potential diagnostic, prognostic, and therapeutic factors in HCC.
Article
Chemistry, Medicinal
Cheng Hu, Haiyue Xu, Zehao Li, Dandan Liu, Siqi Zhang, Fang Fang, Liguo Wang
Summary: The current treatments for prostate cancer are inadequate, and new therapies targeting metabolic alterations in tumor cells are urgently needed. In this study, juglone was found to inhibit energy metabolism in prostate cancer cells, leading to decreased cell proliferation and induction of apoptosis. The inhibition of hexokinase, phosphofructokinase, and pyruvate kinase activities by juglone contributed to its suppressive effects on oxidative phosphorylation and glycolysis in prostate cancer cells.
PHYTOTHERAPY RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiangyun Chen, Bingjie Hao, Dan Li, Russel J. Reiter, Yidong Bai, Baigenzhin Abay, Guojie Chen, Shumeng Lin, Tiansheng Zheng, Yanbei Ren, Xiao Xu, Ming Li, Lihong Fan
Summary: The study found that melatonin can inhibit lung cancer growth by activating Sirt3 and PDH, leading to a reversal of the Warburg effect and an enhancement of mitochondrial energy metabolism.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Oncology
Ying Wang, Ge Jin, Yunfeng Guo, Yuan Cao, Shuhuai Niu, Xiaomei Fan, Jun Zhang
Summary: SMYD2 is highly expressed in human cervical cancer and is associated with poor prognosis. It promotes glycolytic metabolism and tumor growth, mainly through modulating the methylation status of p53.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Cell Biology
Dan Fang, Chengfei Zhang, Ping Xu, Yinhua Liu, Xiao Mo, Qi Sun, Alaa Abdelatty, Chao Hu, Haojun Xu, Guoren Zhou, Hongping Xia, Linhua Lan
Summary: The S100A16 gene, located on chromosome 1q21, is significantly upregulated in pancreatic ductal adenocarcinoma (PDAC) samples. It promotes PDAC progression through FGF19-mediated AKT and ERK1/2 signaling, indicating S100A16 as a promising therapeutic target for PDAC.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hongjin Chen, Xiaoming Wang, Fubing Wu, Xiao Mo, Chao Hu, Mei Wang, Haojun Xu, Chengyun Yao, Hongping Xia, Linhua Lan
Summary: The study showed that CENPF is significantly upregulated in pancreatic cancer tissues and correlated with poor patient prognosis. Silencing CENPF inhibited cell proliferation and migration in pancreatic cancer cells, potentially through the regulation of the TNF pathway and longevity regulating pathways. These findings suggest that CENPF could serve as a novel biomarker for pancreatic cancer.
Article
Chemistry, Medicinal
Hongbao Yang, Abdullahi Mohamed Said, Huimin Huang, Akuetteh Percy David Papa, Guihua Jin, Shijia Wu, Nengfang Ma, Linhua Lan, Fugen Shangguan, Qiyu Zhang
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a severe malignant tumor in human, and chlorogenic Acid (CA) has been found to suppress PDAC cell growth by targeting the c-Myc-TFR1 axis, indicating its potential as a promising compound for PDAC treatment.
PHYTOTHERAPY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kaiyuan Chen, Shanshan Wu, Sisi Ye, Huimin Huang, Yi Zhou, Hongfei Zhou, Shijia Wu, Yefan Mao, Fugen Shangguan, Linhua Lan, Bicheng Chen
Summary: DMF shows promise as a potential novel therapy for cancer treatment by modulating antioxidant pathways and suppressing cell growth in pancreatic cancer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Huimin Huang, Wangxiao Zhou, Renpin Chen, Bingfeng Xiang, Shipeng Zhou, Linhua Lan
Summary: Pancreatic adenocarcinoma (PAAD) is a common cancer with poor outcomes, necessitating the identification of precision biomarkers for early diagnosis and prognosis improvement. The study discovered CXCL10 as a potential prognostic indicator for PAAD patients, negatively correlated with prognosis and positively correlated with tumor cell differentiation. The expression of CXCL10 influenced the immune activity of the tumor microenvironment, suggesting its potential for immune targeted therapy in PAAD treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Yangyang Fang, Shunjie Pei, Kaizhao Huang, Feng Xu, Guangxin Xiang, Linhua Lan, Xiaoqun Zheng
Summary: This study investigated the metabolic and clinical characteristics of a highly malignant subgroup of PDAC using single-cell transcriptome technology. The findings revealed highly malignant cells with abnormally active metabolism, particularly enhanced glycolysis. The identification of five glycolytic marker genes allowed for the prediction of prognosis in PDAC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Alaa Abdelatty, Qi Sun, Junhong Hu, Fubing Wu, Guanqun Wei, Haojun Xu, Guoren Zhou, Xiaoming Wang, Hongping Xia, Linhua Lan
Summary: This study investigates the correlation between PKC genes and tumor immunity, as well as their potential as predictive biomarkers for tumor immunity and immunotherapeutic response. The results suggest that PKC isoenzymes can serve as robust biomarkers for the tumor immune status and can be used as predictors for the response to immunotherapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Shijia Wu, Yong Ai, Huimin Huang, Guangyu Wu, Shipeng Zhou, Weilong Hong, Percy David Papa Akuetteh, Guihua Jin, Xingling Zhao, Yihua Zhang, Xiaolong Zhang, Linhua Lan
Summary: This study demonstrates that B28 disrupts the YTHDF1-GLS1 axis to induce a ROS-dependent cell bioenergetics crisis and cell death, ultimately suppressing PAAD cell growth.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Percy D. P. Akuetteh, Huimin Huang, Shijia Wu, Hongfei Zhou, Guihua Jin, Welong Hong, Hongbao Yang, Linhua Lan, Fugen Shangguan, Qiyu Zhang
Summary: This study investigates the potential antitumor activity of synthetic triterpenoid CDDO-Me in pancreatic ductal adenocarcinoma (PDAC) and reveals the mechanism behind the inhibition of PDAC growth by CDDO-Me through excessive ROS and cellular bioenergetics disruption. Our findings suggest that CDDO-Me could be a potential compound for PDAC therapy, and SLC1A5 could serve as a novel biomarker for PDAC patients.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Plant Sciences
Nengfang Ma, Fugen Shangguan, Hongfei Zhou, Huimin Huang, Jun Lei, Jing An, Guihua Jin, Weiwei Zhuang, Shipeng Zhou, Shijia Wu, Hongping Xia, Hailong Yang, Linhua Lan
Summary: In this study, researchers found that a novel alkaloid named 6-methoxy dihydrosphingosine (6-ME) extracted from M. cordata fruits effectively inhibited the growth of pancreatic cancer cells and promoted apoptosis. The anti-tumor effects of 6-ME were achieved by disrupting OAA metabolism and increasing ROS production, leading to mitochondrial dysfunction and cell death.
Article
Pharmacology & Pharmacy
Wenwen Li, Mengxuan Li, Kaiyuan Chen, Yahui Tang, Ran Yin, Linhua Lan, Guangliang Hong
Summary: The study showed that oxaloacetic acid (OAA) has protective effects on acute lung injury induced by paraquat (PQ) poisoning, improving mitochondrial function and clearing reactive oxygen species (ROS) in cells, ultimately enhancing the survival rate of mice poisoned by PQ.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Lihua Wang, Zheng Zhu, Qi Liang, Yecheng Tao, Gaowei Jin, Yaoyao Zhong, Jichen Dai, Ruixia Dai, Zhixiang Wang, Junbo Chen, Lingjie Zhou, Shouyu Ke, Bin Zheng, Linhua Lan, Xiaokun Lin, Tongke Chen
Summary: This study confirms that WZ35 is a small molecule glycolysis inhibitor that inhibits the proliferation activity of liver cancer cells through metabolic reprogramming. GLUT1-YAP has important reference significance for predicting disease progression stages in liver cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Plant Sciences
Hongfei Zhou, Weiwei Zhuang, Huimin Huang, Nengfang Ma, Jun Lei, Guihua Jin, Shijia Wu, Shipeng Zhou, Xingling Zhao, Linhua Lan, Hongping Xia, Fugen Shangguan
Summary: This study found that 24-epibrassinolide (EBR) can be considered as a potential therapeutic compound for hepatocarcinoma (HCC) due to its pro-apoptosis, restriction of energy metabolism, and other anti-cancer properties. Meanwhile, the high expression of insulin-like growth factor-binding protein 1 (IGFBP1) induced by EBR in HCC contributes to our understanding of the role of IGFBP1 in drug resistance.
Article
Medicine, Research & Experimental
Yangyang Fang, Qiongdan Wang, Kaizhao Huang, Mengyue Zhang, Shunjie Pei, Liyi Li, Ying Peng, Linhua Lan, Xiaoqun Zheng
Summary: This study suggests that HCMV infection is widespread in CRC patients and associated with poor survival outcomes. The regulation of immune function by HCMV may be the key factor in the poor prognosis of CRC patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)