SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

(2022) Kazuhiro Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

(2022) Yunlong Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ORF8 protein of SARS-CoV-2 induced endoplasmic reticulum stress and mediated immune evasion by antagonizing production of interferon beta

(2021) Farooq Rashid et al.   VIRUS RESEARCH

Endoplasmic reticulum stress and NF‐kB activation in SARS‐CoV ‐2 infected cells and their response to antiviral therapy

(2021) Desirée Bartolini et al.   IUBMB LIFE

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

(2021) Yiwen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns

(2021) Natalia Redondo et al.   Frontiers in Immunology

SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione

(2021) Desirée Bartolini et al.   Redox Biology

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

(2021) Di Chen et al.   DEVELOPMENTAL CELL

Biogenesis of secretory immunoglobulin M requires intermediate non‐native disulfide bonds and engagement of the protein disulfide isomerase ERp44

(2021) Chiara Giannone et al.   EMBO JOURNAL

The PRIDE database resources in 2022: a hub for mass spectrometry-based proteomics evidences

(2021) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis

(2021) Ji-Seung Yoo et al.   Nature Communications

The Role of Unfolded Protein Response in Coronavirus Infection and Its Implications for Drug Design

(2021) Mei Xue et al.   Frontiers in Microbiology

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Phosphorylation switches protein disulfide isomerase activity to maintain proteostasis and attenuate ER stress

(2020) Jiaojiao Yu et al.   EMBO JOURNAL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

XBP-1 and the unfolded protein response (UPR)

(2020) Laurie H. Glimcher et al.   NATURE IMMUNOLOGY

Coronavirus replication factories

(2020) Andrea Du Toit   NATURE REVIEWS MICROBIOLOGY

Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

(2020) Barnaby E Young et al.   LANCET

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

Accurate Diagnosis of COVID-19 by a Novel Immunogenic Secreted SARS-CoV-2 orf8 Protein

(2020) Xiaohui Wang et al.   mBio

Integrative Imaging Reveals SARS-CoV-2-Induced Reshaping of Subcellular Morphologies

(2020) Mirko Cortese et al.   Cell Host & Microbe

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein

(2020) Thomas G. Flower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Coronavirus: Host-Pathogen Interaction

(2019) To Sing Fung et al.   Annual Review of Microbiology

Atlastin-mediated membrane tethering is critical for cargo mobility and exit from the endoplasmic reticulum

(2019) Liling Niu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the ERp44-Peroxiredoxin 4 Complex Reveals the Molecular Mechanisms of Thiol-Mediated Protein Retention

(2016) Kai Yang et al.   STRUCTURE

Endoplasmic Reticulum Stress in Immunity

(2015) Sarah E. Bettigole et al.   Annual Review of Immunology

Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone

(2015) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

ERAD and how viruses exploit it

(2014) Hyewon Byun et al.   Frontiers in Microbiology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Synchronization of secretory protein traffic in populations of cells

(2012) Gaelle Boncompain et al.   NATURE METHODS

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

(2010) Fulvio Reggiori et al.   Cell Host & Microbe

The IRE1α-XBP1 Pathway of the Unfolded Protein Response Is Required for Adipogenesis

(2009) Haibo Sha et al.   Cell Metabolism

The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6

(2009) Shu-Chiun Sung et al.   VIROLOGY