Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein

Molecular Simulations suggest Vitamins, Retinoids and Steroids as Ligands of the Free Fatty Acid Pocket of the SARS‐CoV‐2 Spike Protein

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In Silico Study of Polyunsaturated Fatty Acids as Potential SARS-CoV-2 Spike Protein Closed Conformation Stabilizers: Epidemiological and Computational Approaches

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The effect of the D614G substitution on the structure of the spike glycoprotein of SARS-CoV-2

(2021) Donald J. Benton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2

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Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution

(2021) Shuyuan Zhang et al.   Nature Communications

Polyunsaturated ω-3 fatty acids inhibit ACE2-controlled SARS-CoV-2 binding and cellular entry

(2021) Anna Goc et al.   Scientific Reports

SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets

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Disruption of disulfides within RBD of SARS‐CoV‐2 spike protein prevents fusion and represents a target for viral entry inhibition by registered drugs

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Structural impact on SARS-CoV-2 spike protein by D614G substitution

(2021) Jun Zhang et al.   SCIENCE

The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection

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Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants

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SARS-CoV-2 Accessory Proteins in Viral Pathogenesis: Knowns and Unknowns

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Disulfide Bonds Play a Critical Role in the Structure and Function of the Receptor-binding Domain of the SARS-CoV-2 Spike Antigen

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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

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COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models

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A pneumonia outbreak associated with a new coronavirus of probable bat origin

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Structural basis for RNA replication by the SARS-CoV-2 polymerase

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SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

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Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

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Structural basis of receptor recognition by SARS-CoV-2

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Remdesivir for the Treatment of Covid-19 — Preliminary Report

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A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

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An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

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Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

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N-acetylcysteine as a potential treatment for novel coronavirus disease 2019

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Potently neutralizing and protective human antibodies against SARS-CoV-2

(2020) Seth J. Zost et al.   NATURE

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions

(2020) Yingjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

(2020) Christopher O. Barnes et al.   NATURE

Spike mutation D614G alters SARS-CoV-2 fitness

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Free fatty acid binding pocket in the locked structure of SARS-CoV-2 spike protein

(2020) Christine Toelzer et al.   SCIENCE

Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium

(2020) Satria P. Sajuthi et al.   Nature Communications

Therapeutically administered ribonucleoside analogue MK-4482/EIDD-2801 blocks SARS-CoV-2 transmission in ferrets

(2020) Robert M. Cox et al.   Nature Microbiology

Allosteric disulfides: Sophisticated molecular structures enabling flexible protein regulation

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Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis

(2019) Charles R. Esther et al.   Science Translational Medicine

An Improved Inhaled Mucolytic to Treat Airway Muco-Obstructive Diseases

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Systematic and Quantitative Assessment of Hydrogen Peroxide Reactivity With Cysteines Across Human Proteomes

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Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase

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Crystal structure of NL63 respiratory coronavirus receptor-binding domain complexed with its human receptor

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Systematic Assembly of a Full-Length Infectious Clone of Human Coronavirus NL63

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