E4BP4 Coordinates Circadian Control of Cognition in Delirium

Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models

(2021) Tianpeng Zhang et al.   Nature Communications

Primary Microglia Isolation from Postnatal Mouse Brains

(2021) Siling Du et al.   Jove-Journal of Visualized Experiments

Sleep and circadian rhythm disturbances in intensive care unit (ICU)-acquired delirium: a case–control study

(2021) Ting Sun et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Single‐cell transcriptomics of suprachiasmatic nuclei reveal a Prokineticin‐driven circadian network

(2021) Emma L Morris et al.   EMBO JOURNAL

Microglia-specific knock-down of Bmal1 improves memory and protects mice from high fat diet-induced obesity

(2021) Xiao-Lan Wang et al.   MOLECULAR PSYCHIATRY

Period 2 Regulates CYP2B10 Expression and Activity in Mouse Liver

(2021) MengLin Chen et al.   Frontiers in Pharmacology

A CRHR1 antagonist prevents synaptic loss and memory deficits in a trauma-induced delirium-like syndrome

(2020) Silvia Cursano et al.   MOLECULAR PSYCHIATRY

The consistent burden in published estimates of delirium occurrence in medical inpatients over four decades: a systematic review and meta-analysis study

(2020) Kate Gibb et al.   AGE AND AGEING

Hippocampal microglial activation triggers a neurotoxic-specific astrocyte response and mediates etomidate-induced long-term synaptic inhibition

(2020) Dongliang Li et al.   Journal of Neuroinflammation

Circadian rhythm in pharmacokinetics and its relevance to chronotherapy

(2020) Dong Dong et al.   BIOCHEMICAL PHARMACOLOGY

ERK signalling: a master regulator of cell behaviour, life and fate

(2020) Hugo Lavoie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Roles of GABAA receptor α5 subunit on locomotion and working memory in transient forebrain ischemia in mice

(2020) Dong Hyun Kim et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

An NF-κB–driven lncRNA orchestrates colitis and circadian clock

(2020) Shuai Wang et al.   Science Advances

Microglial TonEBP mediates LPS-induced inflammation and memory loss as transcriptional cofactor for NF-κB and AP-1

(2020) Gyu Won Jeong et al.   Journal of Neuroinflammation

REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

(2020) Percy Griffin et al.   eLife

Circadian clock protein Rev-erbα regulates neuroinflammation

(2019) Percy Griffin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-containing Monooxygenase 5 in Mouse Liver

(2019) Min Chen et al.   DRUG METABOLISM AND DISPOSITION

Clock Genes Disruption in the Intensive Care Unit

(2019) Elena Diaz et al.   JOURNAL OF INTENSIVE CARE MEDICINE

E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbα in mice

(2018) Mengjing Zhao et al.   BIOCHEMICAL PHARMACOLOGY

The Period 2 Enhancer Nobiletin as Novel Therapy in Murine Models of Circadian Disruption Resembling Delirium*

(2018) Jennifer Gile et al.   CRITICAL CARE MEDICINE

Delirium in Older Persons

(2017) Esther S. Oh et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche

(2017) Benedetta Artegiani et al.   Cell Reports

Anesthesia and Surgery Impair Blood–Brain Barrier and Cognitive Function in Mice

(2017) Siming Yang et al.   Frontiers in Immunology

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Battery of behavioral tests in mice to study postoperative delirium

(2016) Mian Peng et al.   Scientific Reports

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A

(2016) Inmaculada Segura et al.   Cell Reports

Microglia inflammatory responses are controlled by an intrinsic circadian clock

(2015) Laura K. Fonken et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Microglia activation regulates GluR1 phosphorylation in chronic unpredictable stress-induced cognitive dysfunction

(2015) Mingchao Liu et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Circadian Factor BMAL1 in Histaminergic Neurons Regulates Sleep Architecture

(2014) Xiao Yu et al.   CURRENT BIOLOGY

Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

(2014) Monica R.P. Elmore et al.   NEURON

Systemic Inflammation Impairs Attention and Cognitive Flexibility but Not Associative Learning in Aged Rats: Possible Implications for Delirium

(2014) Deborah J. Culley et al.   Frontiers in Aging Neuroscience

Delirium in elderly people

(2013) Sharon K Inouye et al.   LANCET

Delirium: A disturbance of circadian integrity?

(2013) James M. Fitzgerald et al.   MEDICAL HYPOTHESES

TNF-α modulates expression of the circadian clock genePer2in rheumatoid synovial cells

(2013) K Yoshida et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

TH17 Cell Differentiation Is Regulated by the Circadian Clock

(2013) X. Yu et al.   SCIENCE

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

A longitudinal study of motor subtypes in delirium: Frequency and stability during episodes

(2012) David J. Meagher et al.   JOURNAL OF PSYCHOSOMATIC RESEARCH

Delirium prevalence, incidence, and implications for screening in specialist palliative care inpatient settings: A systematic review

(2012) Annmarie Hosie et al.   PALLIATIVE MEDICINE

Brain Derived Neurotrophic Factor: A novel neurotrophin involved in psychiatric and neurological disorders

(2012) Sivasankaran Balaratnasingam et al.   PHARMACOLOGY & THERAPEUTICS

Postoperative Complications: Delirium

(2012) Steven R. Allen et al.   SURGICAL CLINICS OF NORTH AMERICA

Long-Term Potentiation at CA3–CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress

(2011) Ashok Kumar   Frontiers in Aging Neuroscience

Does Hypoxia Affect Intensive Care Unit Delirium or Long-Term Cognitive Impairment After Multiple Trauma Without Intracranial Hemorrhage?

(2011) Oscar D. Guillamondegui et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Identification of SR8278, a Synthetic Antagonist of the Nuclear Heme Receptor REV-ERB

(2010) Douglas Kojetin et al.   ACS Chemical Biology

The neuroinflammatory hypothesis of delirium

(2010) Joaquim Cerejeira et al.   ACTA NEUROPATHOLOGICA

The Role of ERK1/2 Signaling Pathway in Coronary Microembolization-Induced Rat Myocardial Inflammation and Injury

(2010) Lang Li et al.   CARDIOLOGY

Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

(2009) Shintaro Kamizono et al.   JOURNAL OF EXPERIMENTAL MEDICINE

One-Year Health Care Costs Associated With Delirium in the Elderly Population

(2008) Douglas L. Leslie   ARCHIVES OF INTERNAL MEDICINE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Removal of FKBP12 Enhances mTOR-Raptor Interactions, LTP, Memory, and Perseverative/Repetitive Behavior

(2008) Charles A. Hoeffer et al.   NEURON

Motor Symptoms in 100 Patients With Delirium Versus Control Subjects: Comparison of Subtyping Methods

(2008) David J. Meagher et al.   PSYCHOSOMATICS