Chronic critical illness and post-intensive care syndrome: from pathophysiology to clinical challenges

Clinical Outcomes Among Patients With 1-Year Survival Following Intensive Care Unit Treatment for COVID-19

(2022) Hidde Heesakkers et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness

(2022) Christopher J. Walsh et al.   Journal of Cachexia Sarcopenia and Muscle

Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model

(2021) Chloë Goossens et al.   Journal of Cachexia Sarcopenia and Muscle

Serum Biomarkers of Regeneration and Plasticity are Associated with Functional Outcome in Pediatric Neurocritical Illness: An Exploratory Study

(2021) Catherine Madurski et al.   Neurocritical Care

Long-Term Outcomes and the Post-Intensive Care Syndrome in Critically Ill Children: A North American Perspective

(2021) Alan G. Woodruff et al.   Children-Basel

Tissues, not blood, are where immune cells function

(2021) Donna L. Farber   NATURE

Short-term health-related quality of life, physical function and psychological consequences of severe COVID-19

(2021) Luca Carenzo et al.   Annals of Intensive Care

Long-term quality of life in necrotizing soft-tissue infection survivors: a monocentric prospective cohort study

(2021) Tomas Urbina et al.   Annals of Intensive Care

Energetic dysfunction in sepsis: a narrative review

(2021) Sebastien Preau et al.   Annals of Intensive Care

Chronic Critical Illness and PICS Nutritional Strategies

(2021) Martin D. Rosenthal et al.   Journal of Clinical Medicine

Aerobic exercise capacity in long-term survivors of critical illness: secondary analysis of the post-EPaNIC follow-up study

(2021) Nathalie Van Aerde et al.   INTENSIVE CARE MEDICINE

Sickness Behavior Score Is Associated with Neuroinflammation and Late Behavioral Changes in Polymicrobial Sepsis Animal Model

(2020) Mariana Pereira de Souza Goldim et al.   INFLAMMATION

Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study

(2020) Nathalie Van Aerde et al.   INTENSIVE CARE MEDICINE

ICU-acquired weakness, diaphragm dysfunction and long-term outcomes of critically ill patients

(2020) Clément Saccheri et al.   Annals of Intensive Care

Alterations of B Cells in Immunosuppressive Phase of Septic Shock Patients*

(2020) Xijie Dong et al.   CRITICAL CARE MEDICINE

Contractility and Myofibrillar Content in Skeletal Muscle are Decreased During Post-Sepsis Recovery, but not During the Acute Phase of Sepsis

(2020) Kristen T. Crowell et al.   SHOCK

Cognitive and psychosocial outcomes of mechanically ventilated intensive care patients with and without delirium

(2020) Daniella Bulic et al.   Annals of Intensive Care

CD4 T Cell Responses and the Sepsis-Induced Immunoparalysis State

(2020) Matthew D. Martin et al.   Frontiers in Immunology

Post-intensive care syndrome in paediatrics: setting our sights on survivorship

(2020) Miguel Rodriguez-Rubio et al.   Lancet Child & Adolescent Health

The ubiquitin–proteasome system in regulation of the skeletal muscle homeostasis and atrophy: from basic science to disorders

(2020) Yasuo Kitajima et al.   Journal of Physiological Sciences

Intensive Care Unit—Acquired Weakness in Children: A Prospective Observational Study Using Simplified Serial Electrophysiological Testing (PEDCIMP Study)

(2020) Ananthanarayanan Kasinathan et al.   Neurocritical Care

Early neuromuscular electrical stimulation reduces the loss of muscle mass in critically ill patients – A within subject randomized controlled trial

(2020) Johan Segers et al.   JOURNAL OF CRITICAL CARE

Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repair

(2019) Guillaume Canaud et al.   Science Translational Medicine

Protein recycling and limb muscle recovery after critical illness in slow- and fast-twitch limb muscle

(2019) Sebastien Preau et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Preclinical septic shock research: why we need an animal ICU

(2019) Antoine Guillon et al.   Annals of Intensive Care

Dysfunction of the blood-brain barrier in postoperative delirium patients, referring to the axonal damage biomarker phosphorylated neurofilament heavy subunit

(2019) Kazuhito Mietani et al.   PLoS One

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model

(2019) Allison M Owen et al.   eLife

Dysregulated myelopoiesis and hematopoietic function following acute physiologic insult

(2018) Tyler J. Loftus et al.   CURRENT OPINION IN HEMATOLOGY

The Edmonton Frail Scale Improves the Prediction of 30-day Mortality in Elderly Patients Undergoing Cardiac Surgery: A Prospective Observational Study

(2018) Philippe Amabili et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Life after Critical Illness in Children—Toward an Understanding of Pediatric Post-intensive Care Syndrome

(2018) R. Scott Watson et al.   JOURNAL OF PEDIATRICS

Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury

(2018) Bing Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Psychological and Psychiatric Outcomes Following PICU Admission

(2018) Luís Carlos Lopes-Júnior et al.   Pediatric Critical Care Medicine

Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels

(2018) Elisa Balboa et al.   SHOCK

Post-sepsis cognitive impairment and associated risk factors: A systematic review

(2018) Allan J.C. Calsavara et al.   Australian Critical Care

Factors Associated With Short and Long Term Cognitive Changes in Patients With Sepsis

(2018) Allan J. C. Calsavara et al.   Scientific Reports

Prognostic value of the serum levels of S100B, NSE, and IL-6 in pediatric patients with traumatic brain injury

(2018) Seong-Hyun Park et al.   World Neurosurgery

The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans

(2018) D.J. Wilkinson et al.   AGEING RESEARCH REVIEWS

RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD

(2018) Hui Chen et al.   Cell Death & Disease

Biomarkers and postoperative cognitive function

(2018) Simon T. Schaefer et al.   Current Opinion in Anesthesiology

CSF biomarkers in delirium: a systematic review

(2017) Roanna J. Hall et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

International Survey of Critically Ill Children With Acute Neurologic Insults

(2017) Ericka L. Fink et al.   Pediatric Critical Care Medicine

Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis

(2017) Kristen T. Crowell et al.   SHOCK

Stories of survival: Children’s narratives of psychosocial well-being following paediatric critical illness or injury

(2017) Joseph C Manning et al.   Journal of Child Health Care

Septicemia is associated with increased risk for dementia: a population-based longitudinal study

(2017) Chung-Hsing Chou et al.   Oncotarget

Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?

(2017) Martin Sebastian Winkler et al.   PLoS One

Regulation of Akt-mTOR, ubiquitin-proteasome and autophagy-lysosome pathways in locomotor and respiratory muscles during experimental sepsis in mice

(2017) Jérome Morel et al.   Scientific Reports

No convincing association between post-operative delirium and post-operative cognitive dysfunction: a secondary analysis

(2016) M. Franck et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Mechanisms of Chronic Muscle Wasting and Dysfunction after an Intensive Care Unit Stay. A Pilot Study

(2016) Claudia dos Santos et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ICU-Acquired Weakness

(2016) Sarah E. Jolley et al.   CHEST

Pharmacological Therapy for the Prevention and Treatment of Weakness After Critical Illness

(2016) Stephen J. Shepherd et al.   CRITICAL CARE MEDICINE

Long-Term Quality of Life Among Survivors of Severe Sepsis

(2016) Sachin Yende et al.   CRITICAL CARE MEDICINE

Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity

(2016) Derek B. Danahy et al.   CRITICAL REVIEWS IN IMMUNOLOGY

Proteasome Inhibition After Burn Injury

(2016) P. Geoff Vana et al.   Journal of Burn Care & Research

Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery

(2016) Jan Hirsch et al.   Journal of Neuroinflammation

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

ICU-Acquired Weakness Is Associated With Differences in Clinical Outcomes in Critically Ill Children*

(2016) Aida Field-Ridley et al.   Pediatric Critical Care Medicine

Functional Outcomes and Physical Impairments in Pediatric Critical Care Survivors

(2016) Chengsi Ong et al.   Pediatric Critical Care Medicine

Transcriptomic analysis reveals abnormal muscle repair and remodeling in survivors of critical illness with sustained weakness

(2016) Christopher J. Walsh et al.   Scientific Reports

Exercise rehabilitation following intensive care unit discharge for recovery from critical illness: executive summary of a Cochrane Collaboration systematic review

(2016) Bronwen Connolly et al.   Journal of Cachexia Sarcopenia and Muscle

Assessment and predictors of physical functioning post-hospital discharge in survivors of critical illness

(2016) Kevin J. Solverson et al.   Annals of Intensive Care

The Association of Acute Kidney Injury in the Critically Ill and Postdischarge Outcomes

(2015) Clare M. Horkan et al.   CRITICAL CARE MEDICINE

Marked alterations of neutrophil functions during sepsis-induced immunosuppression

(2015) Julie Demaret et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

(2015) D. P. Basile et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments

(2015) A. Baisantry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Functional Recovery Following Critical Illness in Children

(2015) Karen Choong et al.   Pediatric Critical Care Medicine

Mental and Physical Well-Being Following Admission to Pediatric Intensive Care

(2015) Lorraine C. Als et al.   Pediatric Critical Care Medicine

Sepsis induces long-term metabolic and mitochondrial muscle stem cell dysfunction amenable by mesenchymal stem cell therapy

(2015) P. Rocheteau et al.   Nature Communications

ICU-acquired Weakness, Morbidity, and Death

(2014) Margaret S. Herridge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Acute Outcomes and 1-Year Mortality of Intensive Care Unit–acquired Weakness. A Cohort Study and Propensity-matched Analysis

(2014) Greet Hermans et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Chemotherapy-induced Peripheral Neuropathy Among Paediatric Oncology Patients

(2014) M.J. Purser et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Circulating Immature Granulocytes With T-Cell Killing Functions Predict Sepsis Deterioration*

(2014) Estelle Guérin et al.   CRITICAL CARE MEDICINE

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Long-Term Risk of Coronary Events after AKI

(2014) V.-C. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Kidney Injury and Chronic Kidney Disease as Interconnected Syndromes

(2014) Lakhmir S. Chawla et al.   NEW ENGLAND JOURNAL OF MEDICINE

Risk Factors for Acquiring Functional and Cognitive Disabilities During Admission to a PICU*

(2014) Meredith F. Bone et al.   Pediatric Critical Care Medicine

Persistent Lymphopenia After Diagnosis of Sepsis Predicts Mortality

(2014) Anne M. Drewry et al.   SHOCK

Relationship Between the Functional Status Scale and the Pediatric Overall Performance Category and Pediatric Cerebral Performance Category Scales

(2014) Murray M. Pollack et al.   JAMA Pediatrics

Radiologic Outcomes at 5 Years After Severe ARDS

(2013) M. Elizabeth Wilcox et al.   CHEST

Association between AKI and Long-Term Renal and Cardiovascular Outcomes in United States Veterans

(2013) L. S. Chawla et al.   Clinical Journal of the American Society of Nephrology

Serum Biomarkers of Brain Injury to Classify Outcome After Pediatric Cardiac Arrest*

(2013) Ericka L. Fink et al.   CRITICAL CARE MEDICINE

Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies

(2013) Fabienne Venet et al.   CURRENT OPINION IN IMMUNOLOGY

Early life response to infection

(2013) Peter Ghazal et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Histone Deacetylase Inhibitor Enhances Recovery after AKI

(2013) C. Cianciolo Cosentino et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Progressive endothelin-1 gene activation initiates chronic/end-stage renal disease following experimental ischemic/reperfusion injury

(2013) Richard A. Zager et al.   KIDNEY INTERNATIONAL

Long-Term Cognitive Impairment after Critical Illness

(2013) P.P. Pandharipande et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Outcomes in Pediatric Severe Sepsis

(2013) Reid W. D. Farris et al.   Pediatric Critical Care Medicine

Association between Endothelial Dysfunction and Acute Brain Dysfunction during Critical Illness

(2012) Christopher G. Hughes et al.   ANESTHESIOLOGY

The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging

(2012) Alessandro Morandi et al.   CRITICAL CARE MEDICINE

Biomechanical and Nonfunctional Assessment of Physical Capacity in Male ICU Survivors*

(2012) Jesper B. Poulsen et al.   CRITICAL CARE MEDICINE

Long-term neuromuscular sequelae of critical illness

(2012) Alexander Semmler et al.   JOURNAL OF NEUROLOGY

The developing immune system - from foetus to toddler

(2011) Sofia Ygberg et al.   ACTA PAEDIATRICA

Quality of Life, Pulmonary Function, and Tomographic Scan Abnormalities After ARDS

(2011) Joan R. Masclans et al.   CHEST

Long-term outcomes in survivors of acute respiratory distress syndrome ventilated in supine or prone position

(2011) D. Chiumello et al.   INTENSIVE CARE MEDICINE

Insufficient Activation of Autophagy Allows Cellular Damage to Accumulate in Critically Ill Patients

(2011) Ilse Vanhorebeek et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis

(2011) Steven G. Coca et al.   KIDNEY INTERNATIONAL

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Posttraumatic stress disorder in children and their parents following admission to the pediatric intensive care unit

(2011) Lara P. Nelson et al.   Pediatric Critical Care Medicine

Autophagy inhibition induces atrophy and myopathy in adult skeletal muscles

(2010) Eva Masiero et al.   Autophagy

Sepsis-associated encephalopathy and its differential diagnosis

(2010) Emanuele Iacobone et al.   CRITICAL CARE MEDICINE

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epithelial cell cycle arrest in G2/M mediates kidney fibrosis after injury

(2010) Li Yang et al.   NATURE MEDICINE

EARLY ASSESSMENT OF LEUKOCYTE ALTERATIONS AT DIAGNOSIS OF SEPTIC SHOCK

(2010) Fabienne Venet et al.   SHOCK

Long-term physical outcome in patients with septic shock

(2009) J. B. POULSEN et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

ECMO in ARDS: a long-term follow-up study regarding pulmonary morphology and function and health-related quality of life

(2009) V. B. LINDÉN et al.   ACTA ANAESTHESIOLOGICA SCANDINAVICA

Effects of Age on the Synergistic Interactions between Lipopolysaccharide and Mechanical Ventilation in Mice

(2009) Lincoln S. Smith et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Functional Status Scale: New Pediatric Outcome Measure

(2009) M. M. Pollack et al.   PEDIATRICS

Children's Factual and Delusional Memories of Intensive Care

(2008) Gillian Colville et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Long-term outcome in patients with critical illness myopathy or neuropathy: the Italian multicentre CRIMYNE study

(2008) B Guarneri et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Acute Kidney Injury Leads to Inflammation and Functional Changes in the Brain

(2008) M. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY