Genetics of cerebral malaria: pathogenesis, biomarkers and emerging therapeutic interventions

Diagnostic value of F-18 FDG PET/CT in fever or inflammation of unknown origin in a large single-center retrospective study

(2022) Friedrich Weitzer et al.   Scientific Reports

Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity

(2022) Thanh-Tin P. Nguyen et al.   Frontiers in Pediatrics

Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

(2021) Yvonne Adams et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

(2021) Shigeharu Sato   Journal of Physiological Anthropology

Dynamics of the Composition of Plasmodium Species Contained within Asymptomatic Malaria Infections in the Central Region of Ghana

(2021) Dorcas Bredu et al.   Journal of Tropical Medicine

Using EEG in Resource-Limited Areas: Comparing Qualitative and Quantitative Interpretation Methods in Cerebral Malaria

(2021) Alexander Andrews et al.   PEDIATRIC NEUROLOGY

Human genetics and malaria resistance

(2020) Silvia N. Kariuki et al.   HUMAN GENETICS

Plasmodium asexual growth and sexual development in the haematopoietic niche of the host

(2020) Kannan Venugopal et al.   NATURE REVIEWS MICROBIOLOGY

Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria

(2020) Juan Carlos Cespedes et al.   Frontiers in Genetics

Pathophysiology and neurologic sequelae of cerebral malaria

(2020) Nicoline Schiess et al.   MALARIA JOURNAL

Optical Coherence Tomography Angiography in Neurodegenerative Disorders

(2020) Marco Pellegrini et al.   Journal of Clinical Medicine

Binding of human serum proteins to Plasmodium falciparum-infected erythrocytes and its association with malaria clinical presentation

(2020) Mary Lopez-Perez et al.   MALARIA JOURNAL

Brain Magnetic Resonance Imaging Reveals Different Courses of Disease in Pediatric and Adult Cerebral Malaria

(2020) Praveen K Sahu et al.   CLINICAL INFECTIOUS DISEASES

Cerebral malaria is associated with differential cytoadherence to brain endothelial cells

(2019) Janet Storm et al.   EMBO Molecular Medicine

Evolutionary interplay of single nucleotide polymorphisms at the promoter region of TNF-α gene in different clinical outcomes of malaria in India

(2019) Stuti Mohanty et al.   INFECTION GENETICS AND EVOLUTION

Repeated clinical malaria episodes are associated with modification of the immune system in children

(2019) Yaw Bediako et al.   BMC Medicine

Proceedings #54: Miniature, Easy-to-Use, Disposable EEG for the Emergency Department and Other Points of Care

(2019) Abdel Baki et al.   Brain Stimulation

Blood–Brain Barrier in Cerebral Malaria: Pathogenesis and Therapeutic Intervention

(2019) Gopala Nishanth et al.   TRENDS IN PARASITOLOGY

Severe malaria

(2019) Josef A. Brejt et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Acquisition of IgG to ICAM-1-binding DBLβ domains in the Plasmodium falciparum erythrocyte membrane protein 1 antigen family varies between Groups A, B and C

(2019) Rebecca W. Olsen et al.   INFECTION AND IMMUNITY

Controlled human malaria infection with Plasmodium falciparum demonstrates impact of naturally acquired immunity on virulence gene expression

(2019) Anna Bachmann et al.   PLoS Pathogens

Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria

(2019) Valentina Barrera et al.   Frontiers in Immunology

Malaria: The Past and the Present

(2019) Talapko et al.   Microorganisms

Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it

(2019) Anja Ramstedt Jensen et al.   IMMUNOLOGICAL REVIEWS

The malaria toxin hemozoin induces apoptosis in human neurons and astrocytes: Potential role in the pathogenesis of cerebral malaria

(2019) Eliseo A. Eugenin et al.   BRAIN RESEARCH

Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria

(2019) Tsin W. Yeo et al.   FASEB JOURNAL

CD8+ T cells target cerebrovasculature in children with cerebral malaria

(2019) Brittany A. Riggle et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi

(2018) Catherine Manix Feintuch et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Molecular basis of α-thalassemia

(2018) Samaneh Farashi et al.   BLOOD CELLS MOLECULES AND DISEASES

Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria

(2018) Katherine Plewes et al.   CURRENT OPINION IN INFECTIOUS DISEASES

IgG responses to the Plasmodium falciparum antigen VAR2CSA in Colombia are restricted to pregnancy and are not induced by exposure to P. vivax

(2018) Mary Lopez-Perez et al.   INFECTION AND IMMUNITY

Cutting Edge:Plasmodium falciparumInduces Trained Innate Immunity

(2018) Jacob E. Schrum et al.   JOURNAL OF IMMUNOLOGY

Extensive diversity in the allelic frequency of Plasmodium falciparum merozoite surface proteins and glutamate-rich protein in rural and urban settings of southwestern Nigeria

(2018) Roland I. Funwei et al.   MALARIA JOURNAL

Cytotoxic T Lymphocyte Granzyme-b mediates neuronal cell death during Plasmodium berghei ANKA induced experimental cerebral malaria

(2018) Prabhakar Eeka et al.   NEUROSCIENCE LETTERS

Infected erythrocytes expressing DC13 PfEMP1 differ from recombinant proteins in EPCR-binding function

(2018) Yvonne Azasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resistance toPlasmodium falciparumin sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition

(2018) Natasha M. Archer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania

(2018) Matt Ravenhall et al.   PLoS Genetics

Two complement receptor one alleles have opposing associations with cerebral malaria and interact with α+thalassaemia

(2018) D Herbert Opi et al.   eLife

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study

(2018) Carolyne M Ndila et al.   Lancet Haematology

Immunization with recombinant P. falciparum erythrocyte membrane protein 1 CIDRα1 domains induces domain subtype inhibitory antibodies

(2018) Louise Turner et al.   INFECTION AND IMMUNITY

The Malaria-Protective Human Glycophorin Structural Variant DUP4 Shows Somatic Mosaicism and Association with Hemoglobin Levels

(2018) Walid Algady et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Molecular genotyping of G6PD mutations and Duffy blood group in Afro-descendant communities from Brazilian Amazon

(2018) Haiala S. Silva de Oliveira et al.   GENETICS AND MOLECULAR BIOLOGY

Endothelial glycocalyx regulates cytoadherence in Plasmodium falciparum malaria

(2018) Viola Introini et al.   Journal of the Royal Society Interface

Brain swelling is independent of peripheral plasma cytokine levels in Malawian children with cerebral malaria

(2018) Visopo Harawa et al.   MALARIA JOURNAL

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

(2017) Nicaise Tuikue Ndam et al.   JOURNAL OF INFECTIOUS DISEASES

Brain-derived Neurotrophic Factor Is Associated With Disease Severity and Clinical Outcome in Ugandan Children Admitted to Hospital With Severe Malaria

(2017) Chloe R. McDonald et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Reduction in serum sphingosine 1-phosphate concentration in malaria

(2017) Chuchard Punsawad et al.   PLoS One

Genetic and epigenetic changes in host ABCB1 influences malaria susceptibility to Plasmodium falciparum

(2017) Himanshu Gupta et al.   PLoS One

Resistance to malaria through structural variation of red blood cell invasion receptors

(2017) Ellen M. Leffler et al.   SCIENCE

Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans

(2017) Kimberly F. McManus et al.   PLoS Genetics

Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis

(2017) Richard M. Hoglund et al.   PLOS MEDICINE

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions

(2017) Erin E. Cutts et al.   PLoS Pathogens

Major transcriptional changes observed in the Fulani, an ethnic group less susceptible to malaria

(2017) Jaclyn E Quin et al.   eLife

Cytokines and Chemokines in Cerebral Malaria Pathogenesis

(2017) Josefine Dunst et al.   Frontiers in Cellular and Infection Microbiology

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

(2017) Angelika Hoffmann et al.   Jove-Journal of Visualized Experiments

Malaria

(2017) Margaret A. Phillips et al.   Nature Reviews Disease Primers

Cerebral malaria: insight into pathogenesis, complications and molecular biomarkers

(2017) Farah Hafiz Yusuf et al.   Infection and Drug Resistance

Extensive alterations of blood metabolites in pediatric cerebral malaria

(2017) Sanchit Gupta et al.   PLoS One

A Functional IL22 Polymorphism (rs2227473) Is Associated with Predisposition to Childhood Cerebral Malaria

(2017) Sandrine Marquet et al.   Scientific Reports

Cerebral malaria is associated with long-term mental health disorders: a cross sectional survey of a long-term cohort

(2016) Richard Idro et al.   MALARIA JOURNAL

Cerebral malaria – clinical manifestations and pathogenesis

(2016) Rachna Hora et al.   METABOLIC BRAIN DISEASE

MappingPlasmodium falciparumMortality in Africa between 1990 and 2015

(2016) Peter W. Gething et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

(2016) Catherine Manix Feintuch et al.   mBio

Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum -Infected Erythrocytes to Endothelial Cells

(2016) Marion Avril et al.   mBio

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

(2016) Reetesh Raj Akhouri et al.   Cell Reports

Biology of Malaria Transmission

(2016) Elamaran Meibalan et al.   Cold Spring Harbor Perspectives in Medicine

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

(2016) Phillip A. Swanson et al.   PLoS Pathogens

Cytokine response during non-cerebral and cerebral malaria: evidence of a failure to control inflammation as a cause of death in African adults

(2016) Yakhya Dieye et al.   PeerJ

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

(2015) Samuel C. Wassmer et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Investigating the function of Fc-specific binding of IgM toPlasmodium falciparumerythrocyte membrane protein 1 mediating erythrocyte rosetting

(2015) Liz Stevenson et al.   CELLULAR MICROBIOLOGY

Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain

(2015) Mariana C. Souza et al.   MEDIATORS OF INFLAMMATION

A novel locus of resistance to severe malaria in a region of ancient balancing selection

(2015)   NATURE

Brain Swelling and Death in Children with Cerebral Malaria

(2015) Karl B. Seydel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rifins, rosetting, and red blood cells

(2015) Christian W. Wang et al.   TRENDS IN PARASITOLOGY

Fatal Pediatric Cerebral Malaria Is Associated with Intravascular Monocytes and Platelets That Are Increased with HIV Coinfection

(2015) Sarah E. Hochman et al.   mBio

Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice

(2015) Valérie Soulard et al.   Nature Communications

Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy

(2015) Abdirahman I. Abdi et al.   Scientific Reports

Severity of malaria in relation to a complement receptor 1 polymorphism: a case–control study

(2015) Rebecca Tettey et al.   Pathogens and Global Health

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

(2015) Liz Stevenson et al.   PLoS Pathogens

Pathogenesis of cerebral malaria: new diagnostic tools, biomarkers, and therapeutic approaches

(2015) Praveen K. Sahu et al.   Frontiers in Cellular and Infection Microbiology

Enlightening the malaria parasite life cycle: bioluminescent Plasmodium in fundamental and applied research

(2015) Giulia Siciliano et al.   Frontiers in Microbiology

Quantification of Plasmodium falciparum Histidine-Rich Protein-2 in Cerebrospinal Spinal Fluid from Cerebral Malaria Patients

(2014) Kei Mikita et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Cerebral malaria in children: using the retina to study the brain

(2014) Ian J. C. MacCormick et al.   BRAIN

Plasma Concentration of Parasite DNA as a Measure of Disease Severity in Falciparum Malaria

(2014) Mallika Imwong et al.   JOURNAL OF INFECTIOUS DISEASES

Reappraisal of known malaria resistance loci in a large multicenter study

(2014) Kirk A Rockett et al.   NATURE GENETICS

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD36 and malaria: friends or foes? A decade of data provides some answers

(2014) Ana Cabrera et al.   TRENDS IN PARASITOLOGY

Severe Malaria

(2014)   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

(2014) Saparna Pai et al.   PLoS Pathogens

Pathogenesis of cerebral malaria—inflammation and cytoadherence

(2014) Janet Storm et al.   Frontiers in Cellular and Infection Microbiology

Mechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia

(2014) D. Herbert Opi et al.   EBioMedicine

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

(2013) C. A. Moxon et al.   BLOOD

A mobile phone-based retinal camera for portable wide field imaging

(2013) Robi N Maamari et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Imaging Plasmodium immunobiology in the liver, brain, and lung

(2013) Ute Frevert et al.   PARASITOLOGY INTERNATIONAL

Investigation of Hydrogen Sulfide Gas as a Treatment against P. falciparum, Murine Cerebral Malaria, and the Importance of Thiolation State in the Development of Cerebral Malaria

(2013) Brian DellaValle et al.   PLoS One

High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria

(2013) Selorme Adukpo et al.   PLoS One

Effects of Plasmodium falciparum-infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

(2013) Sarah D'Alessandro et al.   Asian Pacific Journal of Tropical Medicine

Looking through a cranial window

(2013) Jennifer C Volz   Virulence

Contrasting pediatric and adult cerebral malaria

(2013) Michael Hawkes et al.   Virulence

Cerebral tissue oxygenation impairment during experimental cerebral malaria

(2013) Pedro Cabrales et al.   Virulence

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

(2013) Marion Avril et al.   PLoS Pathogens

Acute Brain MRI Findings in 120 Malawian Children with Cerebral Malaria: New Insights into an Ancient Disease

(2012) M.J. Potchen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction

(2012) Mark R. Gillrie et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNAs in parasitic diseases: Potential for diagnosis and targeting

(2012) Raúl Manzano-Román et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Neurologic outcomes in retinopathy-negative cerebral malaria survivors

(2012) D. G. Postels et al.   NEUROLOGY

Inhaled Nitric Oxide and Cerebral Malaria

(2012) Brian Bergmark et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

α-Thalassemia Impairs the Cytoadherence of Plasmodium falciparum-Infected Erythrocytes

(2012) Michael A. Krause et al.   PLoS One

Assessing Diagnostic Tests: How to Correct for the Combined Effects of Interpretation and Reference Standard

(2012) Ahmet Omurtag et al.   PLoS One

Portable Optical Coherence Tomography in Management of Vitreoretinal Diseases: Current Developments, Indications, and Implications

(2012) Lynn L. Huang et al.   Seminars in Ophthalmology

Cerebral malaria

(2012) Laurent Rénia et al.   Virulence

The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection

(2012) Mykola Pinkevych et al.   PLoS Computational Biology

Diagnosing Severe Falciparum Malaria in Parasitaemic African Children: A Prospective Evaluation of Plasma PfHRP2 Measurement

(2012) Ilse C. E. Hendriksen et al.   PLOS MEDICINE

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

Malarial Retinopathy in Bangladeshi Adults

(2011) Abdullah Abu Sayeed et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Low-cost portable fluorescein angiography

(2011) R. J. Maude et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Brain Swelling and Mannitol Therapy in Adult Cerebral Malaria: A Randomized Trial

(2011) S. Mohanty et al.   CLINICAL INFECTIOUS DISEASES

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

Endothelial activation and dysregulation in malaria: a potential target for novel therapeutics

(2011) Hani Kim et al.   CURRENT OPINION IN HEMATOLOGY

Population genetics of malaria resistance in humans

(2011) P W Hedrick   HEREDITY

Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria

(2011) M. J. Ponsford et al.   JOURNAL OF INFECTIOUS DISEASES

Circulating Red Cell–derived Microparticles in Human Malaria

(2011) Duangdao Nantakomol et al.   JOURNAL OF INFECTIOUS DISEASES

Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India

(2011) Vidhan Jain et al.   MALARIA JOURNAL

CD8+ T Cells and IFN-γ Mediate the Time-Dependent Accumulation of Infected Red Blood Cells in Deep Organs during Experimental Cerebral Malaria

(2011) Carla Claser et al.   PLoS One

Identification of Malaria Retinopathy Improves the Specificity of the Clinical Diagnosis of Cerebral Malaria: Findings from a Prospective Cohort Study

(2010) Gretchen L. Birbeck et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Beta-thalassemia

(2010) Antonio Cao et al.   GENETICS IN MEDICINE

Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial

(2010) Arjen M Dondorp et al.   LANCET

Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study

(2010) Gretchen L Birbeck et al.   LANCET NEUROLOGY

Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome

(2010) Richard Idro et al.   PEDIATRIC RESEARCH

Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria

(2010) Joël Bertrand Pankoui Mfonkeu et al.   PLoS One

Microvesiculation and cell interactions at the brain–endothelial interface in cerebral malaria pathogenesis

(2010) Valéry Combes et al.   PROGRESS IN NEUROBIOLOGY

Imaging analysis of the brain in a primate model of cerebral malaria

(2009) Satoru Kawai et al.   ACTA TROPICA

Plasmepsin 4-Deficient Plasmodium berghei Are Virulence Attenuated and Induce Protective Immunity against Experimental Malaria

(2009) Roberta Spaccapelo et al.   AMERICAN JOURNAL OF PATHOLOGY

Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization

(2009) J. Makani et al.   BLOOD

Using malarial retinopathy to improve the classification of children with cerebral malaria

(2008) Susan Lewallen et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE