Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it

First-in-human, randomized, double-blind clinical trial of differentially adjuvanted PAMVAC, a vaccine candidate to prevent pregnancy-associated malaria

(2019) Benjamin Mordmüller et al.   CLINICAL INFECTIOUS DISEASES

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

(2019) Mads Delbo Larsen et al.   Frontiers in Immunology

Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC

(2019) Arnaud Chêne et al.   EBioMedicine

Modified MHC Class II–Associated Invariant Chain Induces Increased Antibody Responses against Plasmodium falciparum Antigens after Adenoviral Vaccination

(2019) Cyrielle Fougeroux et al.   JOURNAL OF IMMUNOLOGY

Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1

(2019) Maria Bernabeu et al.   mBio

The knob protein KAHRP assembles into a ring-shaped structure that underpins virulence complex assembly

(2019) Oliver Looker et al.   PLoS Pathogens

Severe malaria

(2019) Josef A. Brejt et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Comprehensive analysis of Fc-mediated IgM binding to the Plasmodium falciparum erythrocyte membrane protein 1 family in three parasite clones

(2019) Maria del Pilar Quintana et al.   Scientific Reports

The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

(2019) Frederic Sierro et al.   Frontiers in Immunology

Extracellular vesicles from early stage Plasmodium falciparum -infected red blood cells contain PfEMP1 and induce transcriptional changes in human monocytes

(2018) Natália G. Sampaio et al.   CELLULAR MICROBIOLOGY

Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria

(2018) Katherine Plewes et al.   CURRENT OPINION IN INFECTIOUS DISEASES

A vaccine targeted specifically to prevent cerebral malaria – is there hope?

(2018) Lars Hviid et al.   Expert Review of Vaccines

Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria

(2018) Rebecca W. Olsen et al.   INFECTION AND IMMUNITY

Malaria

(2018) Elizabeth A Ashley et al.   LANCET

Convalescent Plasmodium falciparum-specific seroreactivity does not correlate with paediatric malaria severity or Plasmodium antigen exposure

(2018) Anne Kessler et al.   MALARIA JOURNAL

A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection

(2018) Gigliola Zanghì et al.   Cell Reports

Immunization with recombinant P. falciparum erythrocyte membrane protein 1 CIDRα1 domains induces domain subtype inhibitory antibodies

(2018) Louise Turner et al.   INFECTION AND IMMUNITY

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Cerebral Malaria in Mouse and Man

(2018) Nazanin Ghazanfari et al.   Frontiers in Immunology

Pre-clinical and clinical development of the first placental malaria vaccine

(2017) Caroline Pehrson et al.   Expert Review of Vaccines

Parasites Causing Cerebral Falciparum Malaria Bind Multiple Endothelial Receptors and Express EPCR and ICAM-1-Binding PfEMP1

(2017) Nicaise Tuikue Ndam et al.   JOURNAL OF INFECTIOUS DISEASES

Margination of Stiffened Red Blood Cells Regulated By Vessel Geometry

(2017) Yuanyuan Chen et al.   Scientific Reports

Structural analysis of P. falciparum KAHRP and PfEMP1 complexes with host erythrocyte spectrin suggests a model for cytoadherent knob protrusions

(2017) Erin E. Cutts et al.   PLoS Pathogens

A quantitative brain map of experimental cerebral malaria pathology

(2017) Patrick Strangward et al.   PLoS Pathogens

Emerging roles for hemostatic dysfunction in malaria pathogenesis

(2016) J. M. OSullivan et al.   BLOOD

Plasmodium falciparum vargenes expressed in children with severe malaria encode CIDRα1 domains

(2016) Jakob S Jespersen et al.   EMBO Molecular Medicine

Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria

(2016) Julio Gallego-Delgado et al.   JOURNAL OF CLINICAL INVESTIGATION

Differences in PfEMP1s recognized by antibodies from patients with uncomplicated or severe malaria

(2016) Michael F. Duffy et al.   MALARIA JOURNAL

Cerebral malaria – clinical manifestations and pathogenesis

(2016) Rachna Hora et al.   METABOLIC BRAIN DISEASE

Plasmodium species: master renovators of their host cells

(2016) Tania F. de Koning-Ward et al.   NATURE REVIEWS MICROBIOLOGY

Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass

(2016) Maria Bernabeu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis

(2016) Priya Pal et al.   mBio

Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum -Infected Erythrocytes to Endothelial Cells

(2016) Marion Avril et al.   mBio

The structural basis for CD36 binding by the malaria parasite

(2016) Fu-Lien Hsieh et al.   Nature Communications

Architecture of Human IgM in Complex with P. falciparum Erythrocyte Membrane Protein 1

(2016) Reetesh Raj Akhouri et al.   Cell Reports

Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach

(2015) Samuel C. Wassmer et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes

(2015) J. M. Watermeyer et al.   BLOOD

Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

(2015) Clinton K.Y. Lau et al.   Cell Host & Microbe

Investigating the function of Fc-specific binding of IgM toPlasmodium falciparumerythrocyte membrane protein 1 mediating erythrocyte rosetting

(2015) Liz Stevenson et al.   CELLULAR MICROBIOLOGY

Diverse functional outcomes ofPlasmodium falciparumligation of EPCR: potential implications for malarial pathogenesis

(2015) Mark R. Gillrie et al.   CELLULAR MICROBIOLOGY

Plasmodium falciparumadhesion domains linked to severe malaria differ in blockade of endothelial protein C receptor

(2015) Sowmya Sampath et al.   CELLULAR MICROBIOLOGY

ThePlasmodium falciparumblood stages acquire factor H family proteins to evade destruction by human complement

(2015) Thiago F. A. Rosa et al.   CELLULAR MICROBIOLOGY

IgG Antibodies to Endothelial Protein C Receptor-Binding Cysteine-Rich Interdomain Region Domains of Plasmodium falciparum Erythrocyte Membrane Protein 1 Are Acquired Early in Life in Individuals Exposed to Malaria

(2015) Louise Turner et al.   INFECTION AND IMMUNITY

Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 Variants per Genome Can Bind IgM via Its Fc Fragment Fcμ

(2015) Anine Jeppesen et al.   INFECTION AND IMMUNITY

Mapping the Binding Site of a Cross-ReactivePlasmodium falciparumPfEMP1 Monoclonal Antibody Inhibitory of ICAM-1 Binding

(2015) Frank Lennartz et al.   JOURNAL OF IMMUNOLOGY

Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria

(2015) Danny A. Milner et al.   JOURNAL OF INFECTIOUS DISEASES

Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

(2015) Helle Holm Hansson et al.   MALARIA JOURNAL

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

(2015) Suchi Goel et al.   NATURE MEDICINE

Brain Swelling and Death in Children with Cerebral Malaria

(2015) Karl B. Seydel et al.   NEW ENGLAND JOURNAL OF MEDICINE

HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults

(2015) Krishanthi S. Subramaniam et al.   PLoS One

Protein C system defects inflicted by the malaria parasite protein PfEMP1 can be overcome by a soluble EPCR variant

(2015) Eveline A. M. Bouwens et al.   THROMBOSIS AND HAEMOSTASIS

Rifins, rosetting, and red blood cells

(2015) Christian W. Wang et al.   TRENDS IN PARASITOLOGY

Differential Plasmodium falciparum surface antigen expression among children with Malarial Retinopathy

(2015) Abdirahman I. Abdi et al.   Scientific Reports

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes

(2015) Liz Stevenson et al.   PLoS Pathogens

Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial

(2015) Juliet Mwanga-Amumpaire et al.   Open Forum Infectious Diseases

Binding of Subdomains 1/2 of PfEMP1-DBL1α to Heparan Sulfate or Heparin Mediates Plasmodium falciparum Rosetting

(2015) Davide Angeletti et al.   PLoS One

Cerebral malaria in children: using the retina to study the brain

(2014) Ian J. C. MacCormick et al.   BRAIN

Evidence of promiscuous endothelial binding byPlasmodium falciparum-infected erythrocytes

(2014) Claudia Esser et al.   CELLULAR MICROBIOLOGY

A lysine-rich membrane-associated PHISTb protein involved in alteration of the cytoadhesive properties of Plasmodium falciparum-infected red blood cells

(2014) Nicholas I. Proellocks et al.   FASEB JOURNAL

A Plasmodium falciparum PHIST protein binds the virulence factor PfEMP1 and comigrates to knobs on the host cell surface

(2014) Alexander Oberli et al.   FASEB JOURNAL

Identification of Residues in the C 4 Domain of Polymeric IgM Essential for Interaction with Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1)

(2014) A. Ghumra et al.   JOURNAL OF IMMUNOLOGY

Endothelial Microparticles Interact with and Support the Proliferation of T Cells

(2014) Julie Wheway et al.   JOURNAL OF IMMUNOLOGY

High Plasma Levels of Soluble Endothelial Protein C Receptor Are Associated With Increased Mortality Among Children With Cerebral Malaria in Benin

(2014) Azizath Moussiliou et al.   JOURNAL OF INFECTIOUS DISEASES

Severity of Retinopathy Parallels the Degree of Parasite Sequestration in the Eyes and Brains of Malawian Children With Fatal Cerebral Malaria

(2014) Valentina Barrera et al.   JOURNAL OF INFECTIOUS DISEASES

Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malaria

(2014) Izumi Naka et al.   MALARIA JOURNAL

P. falciparum Isolate-Specific Distinct Patterns of Induced Apoptosis in Pulmonary and Brain Endothelial Cells

(2014) Nadine N'Dilimabaka et al.   PLoS One

Endothelial Protein C Receptor Gene Variants Not Associated with Severe Malaria in Ghanaian Children

(2014) Kathrin Schuldt et al.   PLoS One

CD36 and malaria: friends or foes? A decade of data provides some answers

(2014) Ana Cabrera et al.   TRENDS IN PARASITOLOGY

Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology

(2014) Dumizulu L. Tembo et al.   PLoS Pathogens

Microparticles: A New Perspective in Central Nervous System Disorders

(2014) Stephanie M. Schindler et al.   Biomed Research International

Pathogenesis of cerebral malaria—inflammation and cytoadherence

(2014) Janet Storm et al.   Frontiers in Cellular and Infection Microbiology

The systemic pathology of cerebral malaria in African children

(2014) Danny A. Milner et al.   Frontiers in Cellular and Infection Microbiology

Plasmodium falciparum picks (on) EPCR

(2013) W. C. Aird et al.   BLOOD

Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children

(2013) C. A. Moxon et al.   BLOOD

Malaria's deadly grip: cytoadhesion ofPlasmodium falciparum-infected erythrocytes

(2013) Joseph D. Smith et al.   CELLULAR MICROBIOLOGY

Rosetting Plasmodium falciparum-Infected Erythrocytes Bind to Human Brain Microvascular Endothelial CellsIn Vitro, Demonstrating a Dual Adhesion Phenotype Mediated by Distinct P. falciparum Erythrocyte Membrane Protein 1 Domains

(2013) Yvonne Adams et al.   INFECTION AND IMMUNITY

Molecular Architecture of a Complex between an Adhesion Protein from the Malaria Parasite and Intracellular Adhesion Molecule 1

(2013) Alan Brown et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children

(2013) Christopher A. Moxon et al.   JOURNAL OF INFECTIOUS DISEASES

Mechanisms of anticoagulant and cytoprotective actions of the protein C pathway

(2013) E. A. M. Bouwens et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Severe malaria is associated with parasite binding to endothelial protein C receptor

(2013) Louise Turner et al.   NATURE

Malaria biology and disease pathogenesis: insights for new treatments

(2013) Louis H Miller et al.   NATURE MEDICINE

Development, maintenance and disruption of the blood-brain barrier

(2013) Birgit Obermeier et al.   NATURE MEDICINE

Cytoadherence characteristics to endothelial receptors ICAM-1 and CD36 ofPlasmodium falciparumpopulations from severe and uncomplicated malaria cases

(2013) S. Cojean et al.   Parasite

Expression of the Domain Cassette 8 Plasmodium falciparum Erythrocyte Membrane Protein 1 Is Associated with Cerebral Malaria in Benin

(2013) Gwladys I. Bertin et al.   PLoS One

High Plasma Levels of Soluble Intercellular Adhesion Molecule (ICAM)-1 Are Associated with Cerebral Malaria

(2013) Selorme Adukpo et al.   PLoS One

Endothelial microparticles: Sophisticated vesicles modulating vascular function

(2013) Anne M Curtis et al.   VASCULAR MEDICINE

Effects of Plasmodium falciparum-infected erythrocytes on matrix metalloproteinase-9 regulation in human microvascular endothelial cells

(2013) Sarah D'Alessandro et al.   Asian Pacific Journal of Tropical Medicine

Contrasting pediatric and adult cerebral malaria

(2013) Michael Hawkes et al.   Virulence

DC8 and DC13 var Genes Associated with Severe Malaria Bind Avidly to Diverse Endothelial Cells

(2013) Marion Avril et al.   PLoS Pathogens

The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

(2013) Robert Noble et al.   eLife

Plasmodium falciparum Histones Induce Endothelial Proinflammatory Response and Barrier Dysfunction

(2012) Mark R. Gillrie et al.   AMERICAN JOURNAL OF PATHOLOGY

Seasonal Differences in Retinopathy-Negative versus Retinopathy-Positive Cerebral Malaria

(2012) Douglas G. Postels et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria

(2012) Andrea L. Conroy et al.   CRITICAL CARE MEDICINE

Cerebral malaria pathogenesis: revisiting parasite and host contributions

(2012) Georges Emile Raymond Grau et al.   Future Microbiology

Structural and Functional Insight into How thePlasmodium falciparumVAR2CSA Protein Mediates Binding to Chondroitin Sulfate A in Placental Malaria

(2012) Thomas M. Clausen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Domain Cassette Identifies Plasmodium falciparum PfEMP1 Proteins Binding ICAM-1 and Is a Target of Cross-Reactive, Adhesion-Inhibitory Antibodies

(2012) A. Bengtsson et al.   JOURNAL OF IMMUNOLOGY

Plasma Concentrations of Parasite Histidine-Rich Protein 2 Distinguish Between Retinopathy-Positive and Retinopathy-Negative Cerebral Malaria in Malawian Children

(2012) K. B. Seydel et al.   JOURNAL OF INFECTIOUS DISEASES

Inhaled Nitric Oxide and Cerebral Malaria

(2012) Brian Bergmark et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

α-Thalassemia Impairs the Cytoadherence of Plasmodium falciparum-Infected Erythrocytes

(2012) Michael A. Krause et al.   PLoS One

The Density of Knobs on Plasmodium falciparum-Infected Erythrocytes Depends on Developmental Age and Varies among Isolates

(2012) Katharina A. Quadt et al.   PLoS One

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

(2012) A. Claessens et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A restricted subset of var genes mediates adherence of Plasmodium falciparum-infected erythrocytes to brain endothelial cells

(2012) M. Avril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

(2012) T. Lavstsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prognostic Indicators of Life-Threatening Malaria Are Associated with Distinct Parasite Variant Antigen Profiles

(2012) G. M. Warimwe et al.   Science Translational Medicine

The Role of Animal Models for Research on Severe Malaria

(2012) Alister G. Craig et al.   PLoS Pathogens

The Neuropathology of Fatal Cerebral Malaria in Malawian Children

(2011) Katerina Dorovini-Zis et al.   AMERICAN JOURNAL OF PATHOLOGY

Functional architecture of Weibel-Palade bodies

(2011) K. M. Valentijn et al.   BLOOD

Malaria: modification of the red blood cell and consequences in the human host

(2011) Christopher A. Moxon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium

(2011) Mauro Prato et al.   CELLULAR MICROBIOLOGY

The case for PfEMP1-based vaccines to protect pregnant women againstPlasmodium falciparummalaria

(2011) Lars Hviid   Expert Review of Vaccines

Sequestration and Microvascular Congestion Are Associated With Coma in Human Cerebral Malaria

(2011) M. J. Ponsford et al.   JOURNAL OF INFECTIOUS DISEASES

Unknown

(2011) Constance Finney et al.   MOLECULAR MEDICINE

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Combinations of Host Biomarkers Predict Mortality among Ugandan Children with Severe Malaria: A Retrospective Case-Control Study

(2011) Laura K. Erdman et al.   PLoS One

Specific Receptor Usage in Plasmodium falciparum Cytoadherence Is Associated with Disease Outcome

(2011) Lucy B. Ochola et al.   PLoS One

Association of Severe Malaria Outcomes with Platelet-Mediated Clumping and Adhesion to a Novel Host Receptor

(2011) Alfredo Mayor et al.   PLoS One

Evasion of immunity to Plasmodium falciparum malaria by IgM masking of protective IgG epitopes in infected erythrocyte surface-exposed PfEMP1

(2011) L. Barfod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemoglobins S and C Interfere with Actin Remodeling in Plasmodium falciparum-Infected Erythrocytes

(2011) M. Cyrklaff et al.   SCIENCE

Antigenic Variation in Plasmodium falciparum Malaria Involves a Highly Structured Switching Pattern

(2011) Mario Recker et al.   PLoS Pathogens

Investigating the Host Binding Signature on the Plasmodium falciparum PfEMP1 Protein Family

(2011) Joel H. Janes et al.   PLoS Pathogens

Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF

(2010) Samuel Crocodile Wassmer et al.   CELLULAR MICROBIOLOGY

Hierarchical, Domain Type-Specific Acquisition of Antibodies to Plasmodium falciparum Erythrocyte Membrane Protein 1 in Tanzanian Children

(2010) G. K. K. Cham et al.   INFECTION AND IMMUNITY

Metabolic Acidosis Induced by Plasmodium Falciparum Intraerythrocytic Stages Alters Blood—Brain Barrier Integrity

(2010) Sergine Zougbédé et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

DifferentialvarGene Expression in Children with Malaria and Antidromic Effects on Host Gene Expression

(2010) Yvonne Kalmbach et al.   JOURNAL OF INFECTIOUS DISEASES

The age patterns of severe malaria syndromes in sub-Saharan Africa across a range of transmission intensities and seasonality settings

(2010) Arantxa Roca-Feltrer et al.   MALARIA JOURNAL

Cerebral Malaria: Mechanisms of Brain Injury and Strategies for Improved Neurocognitive Outcome

(2010) Richard Idro et al.   PEDIATRIC RESEARCH

Endothelium-Based Biomarkers Are Associated with Cerebral Malaria in Malawian Children: A Retrospective Case-Control Study

(2010) Andrea L. Conroy et al.   PLoS One

Elevated Cell-Specific Microparticles Are a Biological Marker for Cerebral Dysfunctions in Human Severe Malaria

(2010) Joël Bertrand Pankoui Mfonkeu et al.   PLoS One

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

(2010) A. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microvesiculation and cell interactions at the brain–endothelial interface in cerebral malaria pathogenesis

(2010) Valéry Combes et al.   PROGRESS IN NEUROBIOLOGY

Plasmodium falciparum Erythrocyte Membrane Protein 1 Diversity in Seven Genomes – Divide and Conquer

(2010) Thomas S. Rask et al.   PLoS Computational Biology

Surface Co-Expression of Two Different PfEMP1 Antigens on Single Plasmodium falciparum-Infected Erythrocytes Facilitates Binding to ICAM1 and PECAM1

(2010) Louise Joergensen et al.   PLoS Pathogens

Plasmodium falciparum Adhesion on Human Brain Microvascular Endothelial Cells Involves Transmigration-Like Cup Formation and Induces Opening of Intercellular Junctions

(2010) Ronan Jambou et al.   PLoS Pathogens

Plasmodium falciparum-infected erythrocytes induce NF- B regulated inflammatory pathways in human cerebral endothelium

(2009) A. K. Tripathi et al.   BLOOD

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

(2009) D. J. Bridges et al.   BLOOD

Sequential, Ordered Acquisition of Antibodies to Plasmodium falciparum Erythrocyte Membrane Protein 1 Domains

(2009) G. K. K. Cham et al.   JOURNAL OF IMMUNOLOGY

Analysis ofPlasmodium falciparum varGenes Expressed in Children from Papua New Guinea

(2009) Nicole Falk et al.   JOURNAL OF INFECTIOUS DISEASES

Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria

(2009) Andrea L Conroy et al.   MALARIA JOURNAL

Dysregulation of coagulation in cerebral malaria

(2009) Christopher Alan Moxon et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment

(2009) Katie R. Hughes et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Angiopoietin 2 Is a Partial Agonist/Antagonist of Tie2 Signaling in the Endothelium

(2009) H. T. Yuan et al.   MOLECULAR AND CELLULAR BIOLOGY

Diagnosis and management of the neurological complications of falciparum malaria

(2009) Saroj K. Mishra et al.   Nature Reviews Neurology

Serum Angiopoietin-1 and -2 Levels Discriminate Cerebral Malaria from Uncomplicated Malaria and Predict Clinical Outcome in African Children

(2009) Fiona E. Lovegrove et al.   PLoS One

Plasmodium falciparum var gene expression is modified by host immunity

(2009) G. M. Warimwe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The murine cerebral malaria phenomenon

(2009) Nicholas J. White et al.   TRENDS IN PARASITOLOGY

High Throughput Functional Assays of the Variant Antigen PfEMP1 Reveal a Single Domain in the 3D7 Plasmodium falciparum Genome that Binds ICAM1 with High Affinity and Is Targeted by Naturally Acquired Neutralizing Antibodies

(2009) Andrew V. Oleinikov et al.   PLoS Pathogens

Severe Plasmodium falciparum Malaria Is Associated with Circulating Ultra-Large von Willebrand Multimers and ADAMTS13 Inhibition

(2009) Deirdre Larkin et al.   PLoS Pathogens

Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia

(2008) Julie Gavard et al.   DEVELOPMENTAL CELL

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

(2008) Matthew K. Higgins   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet‐Induced Clumping ofPlasmodium falciparum–Infected Erythrocytes from Malawian Patients with Cerebral Malaria—Possible Modulation In Vivo by Thrombocytopenia

(2008) Samuel Crocodile Wassmer et al.   JOURNAL OF INFECTIOUS DISEASES

Rho Kinase Inhibition in Severe Malaria: Thwarting Parasite‐Induced Collateral Damage to Endothelia

(2008) Zacharie Taoufiq et al.   JOURNAL OF INFECTIOUS DISEASES

CD36 selection of 3D7 Plasmodium falciparum associated with severe childhood malaria results in reduced VAR4 expression

(2008) Pamela A Magistrado et al.   MALARIA JOURNAL

Blood Coagulation, Inflammation, and Malaria

(2008) Ivo M. B. Francischetti et al.   MICROCIRCULATION

Soluble factors from Plasmodium falciparum-infected erythrocytes induce apoptosis in human brain vascular endothelial and neuroglia cells

(2008) N WILSON et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Plasmodium falciparumantigenic variation. Mapping mosaicvargene sequences onto a network of shared, highly polymorphic sequence blocks

(2008) Peter C. Bull et al.   MOLECULAR MICROBIOLOGY

Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1

(2008) Shigetomo Fukuhara et al.   NATURE CELL BIOLOGY

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Control of pathogenic CD8+T cell migration to the brain by IFN-γ during experimental cerebral malaria

(2008) E. BELNOUE et al.   PARASITE IMMUNOLOGY

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria

(2008) T. W. Yeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired cytoadherence of Plasmodium falciparum-infected erythrocytes containing sickle hemoglobin

(2008) R. Cholera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using malarial retinopathy to improve the classification of children with cerebral malaria

(2008) Susan Lewallen et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

The eye in cerebral malaria: what can it teach us?

(2008) Richard J. Maude et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Rosetting in Plasmodium falciparum: A cytoadherence phenotype with multiple actors

(2008) O. Mercereau-Puijalon et al.   TRANSFUSION CLINIQUE ET BIOLOGIQUE

Does activation of the blood coagulation cascade have a role in malaria pathogenesis?

(2008) Ivo M.B. Francischetti   TRENDS IN PARASITOLOGY

Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology

(2008) Peter F Davies   Nature clinical practice. Cardiovascular medicine

Direct In Vivo Assessment of Microcirculatory Dysfunction in Severe Falciparum Malaria

(2007) A. M. Dondorp et al.   JOURNAL OF INFECTIOUS DISEASES