Siglec-15-induced autophagy promotes invasion and metastasis of human osteosarcoma cells by activating the epithelial–mesenchymal transition and Beclin-1/ATG14 pathway

Long Noncoding RNA TUG1 Inhibits Tumor Progression through Regulating Siglec-15-Related Anti-Immune Activity in Hepatocellular Carcinoma

(2022) Yanyi Ren et al.   Journal of Immunology Research

Regulation of PD-L1 expression in the tumor microenvironment

(2021) Ming Yi et al.   Journal of Hematology & Oncology

Sialic acid-binding immunoglobulin-like lectin-15 expression on peritumoral macrophages is a favorable prognostic factor for primary central nervous system lymphoma patients

(2021) Hirotaka Fudaba et al.   Scientific Reports

SOX2 promotes chemoresistance, cancer stem cells properties, and epithelial–mesenchymal transition by β-catenin and Beclin1/autophagy signaling in colorectal cancer

(2021) Yin Zhu et al.   Cell Death & Disease

Siglec‐15 promotes the migration of liver cancer cells by repressing lysosomal degradation of CD44

(2021) Weitao Liu et al.   FEBS LETTERS

Siglec-15 Promotes Tumor Progression in Osteosarcoma via DUSP1/MAPK Pathway

(2021) Meng-ke Fan et al.   Frontiers in Oncology

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

(2021) Hiroyuki Tsukazaki et al.   BONE

Role of RHO family interacting cell polarization regulators (RIPORs) in health and disease: Recent advances and prospects

(2021) Zeheng Lv et al.   International Journal of Biological Sciences

PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy

(2021) Yiqi Xu et al.   Journal for ImmunoTherapy of Cancer

The diverse functions of Siglec-15 in bone remodeling and antitumor responses

(2020) Fu-biao Kang et al.   PHARMACOLOGICAL RESEARCH

LINC00973 involves in cancer immune suppression through positive regulation of Siglec‐15 in ccRCC

(2020) Yanbin Liu et al.   CANCER SCIENCE

Tumor-Associated Macrophages in Osteosarcoma: From Mechanisms to Therapy

(2020) Francesca Cersosimo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytoskeletal Crosstalk in Cell Migration

(2020) Shailaja Seetharaman et al.   TRENDS IN CELL BIOLOGY

Autophagy and the Wnt signaling pathway: A focus on Wnt/β-catenin signaling

(2020) Shahrokh Lorzadeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs

(2020) Chenglong Chen et al.   CANCER LETTERS

Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways

(2019) Tingting Ren et al.   Cell Death & Disease

Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy

(2019) Jun Wang et al.   NATURE MEDICINE

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy

(2019) Hong-Tao Chen et al.   Molecular Cancer

TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status

(2019) Chen Liang et al.   Autophagy

A PAK5–DNPEP–USP4 axis dictates breast cancer growth and metastasis

(2019) Nanxi Geng et al.   INTERNATIONAL JOURNAL OF CANCER

M1 Macrophages Induce PD-L1 Expression in Hepatocellular Carcinoma Cells Through IL-1β Signaling

(2019) Zhaoyun Zong et al.   Frontiers in Immunology

Assessment of the expression of the immune checkpoint molecules PD‐1, CTLA4, TIM‐3 and LAG‐3 across different cancers in relation to treatment response, tumor‐infiltrating immune cells and survival

(2019) Lei Tu et al.   INTERNATIONAL JOURNAL OF CANCER

Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study

(2018) Nathalie Gaspar et al.   EUROPEAN JOURNAL OF CANCER

Inhibitory functions of PD-L1 and PD-L2 in the regulation of anti-tumor immunity in murine tumor microenvironment

(2018) Daisuke Umezu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Synergistic inhibitory effects of capsaicin combined with cisplatin on human osteosarcoma in culture and in xenografts

(2018) Yang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

EMT Transition States during Tumor Progression and Metastasis

(2018) Ievgenia Pastushenko et al.   TRENDS IN CELL BIOLOGY

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy

(2016) M Gugnoni et al.   ONCOGENE

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF

(2016) Tatsushi Yoshida et al.   Oncotarget

Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3

(2016) Marina N. Sharifi et al.   Cell Reports

MAPK/JNK signaling: A potential autophagy regulation pathway

(2015) Yuan-Yuan Zhou et al.   BIOSCIENCE REPORTS

Siglec-15 Regulates Osteoclast Differentiation by Modulating RANKL-Induced Phosphatidylinositol 3-Kinase/Akt and Erk Pathways in Association With Signaling Adaptor DAP12

(2013) Yusuke Kameda et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-  secretion from monocytes/macrophages through the DAP12-Syk pathway

(2012) R. Takamiya et al.   GLYCOBIOLOGY

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY