Article
Biochemical Research Methods
Mirza Jawad ul Hasnain, Farhat Amin, Aisha Ghani, Sibtain Ahmad, Ziaur Rahman, Tahera Aslam, Muhammad Tariq Pervez
Summary: The aim of this study was to analyze the structural and functional impact of mutations in the VPS35 protein on Parkinson's disease. The results showed that the mutations Y67H, R524W, and D620N have an impact on the structure and function of the VPS35 protein. These findings are important for drug design against diseases caused by these mutations.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS
(2022)
Article
Genetics & Heredity
Abid Ali Shah, Marryam Amjad, Jawad-Ul Hassan, Asmat Ullah, Arif Mahmood, Huiyin Deng, Yasir Ali, Fouzia Gul, Kun Xia
Summary: Investigated the impact of genetic variations in the GluN2B coding gene (GRIN2B) on neurodevelopmental diseases and found that multiple GRIN2B genetic variations are linked to neurodevelopmental problems.
Article
Neurosciences
Stefan F. Lichtenthaler, Sarah K. Tschirner, Harald Steiner
Summary: Secretases are key drug targets for preventing and treating Alzheimer's disease, involving the cleavage of APP and TREM2. Recent discoveries highlight the role of alpha-secretases and novel proteins in controlling alpha- and beta-secretase activity. Opportunities and challenges exist for pharmacologically targeting secretases to prevent or treat AD.
CURRENT OPINION IN NEUROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yiqiong Zhang, Hanwen Liu, Siyuan Zhao, Chao Xie, Zhenguo Huang, Shuangyin Wang
Summary: This review focuses on the formation and preparation of defects, the dynamic evolution process of defects, and the influence of defect dynamic evolution on catalytic reactions. The summary of the current advances in the dynamic evolution process of defects in various catalytic reactions is expected to provide a comprehensive understanding of the role of defective electrocatalysts in the structural evolution process and reaction mechanisms.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Joanna Zamel, Jiaxing Chen, Sofia Zaer, Paul David Harris, Paz Drori, Mario Lebendiker, Nir Kalisman, Nikolay V. Dokholyan, Eitan Lerner
Summary: Parkinson disease is associated with the aggregation of α-synuclein protein. In vitro experiments show that α-synuclein exists primarily as a monomer-dimer equilibrium in nanomolar to micromolar concentrations. By using cross-linking mass spectrometry and molecular dynamics simulations, a compact and stable dimer with partially exposed β-sheet structures is identified. This dimer, characterized by the proximity of tyrosine 39 hydroxyls, may play a role in the formation of α-synuclein amyloid fibrils and have etiological relevance to Parkinson disease.
Review
Medicine, General & Internal
Thomas Benzing, David Salant
Summary: This review focuses on the roles of glomerular capillary pressure, the glomerular basement membrane, and podocytes in regulating glomerular filtration and permeability, which are essential in understanding the pathogenesis of chronic kidney diseases.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Chengyi Hu, Ruihao Chen, Nanfeng Zheng
Summary: The interfaces between inorganic functional nanomaterials and their surface modifiers are crucial in determining their properties. Strategies to design model inorganic nanomaterials with well-defined interfaces can simplify the investigation of interfacial effects on performance enhancement. Atomically precise metal nanoclusters and ultrathin low-dimensional nanomaterials modified with organic ligands help understand how interfacial effects influence catalysis.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Binwen Sun, Ji Lv, Jin Chen, Zheyi Liu, Ye Zhou, Lin Liu, Yan Jin, Fangjun Wang
Summary: The study presents a size-selective VAILase proteolysis-mass spectrometry strategy to monitor protein structure changes without strict control of proteolysis kinetics. The unique conformation selectivity is achieved through the uniform nano-sized entrance pores of the VAILase hexameric cage and six inherent molecular rulers in substrate recognition and cleavage. The SVP strategy successfully captures dynamic insights into subtle conformation alterations in myoglobin unfolding transition and Aurora kinase A-inhibitor binding, matching well with molecular dynamics simulation results.
ANALYTICAL CHEMISTRY
(2021)
Review
Food Science & Technology
Yuxuan Zhao, Weiheng He, Sihan Zhao, Teng Jiao, Haifang Hu, Jingming Li, Lei Zhang, Jiachen Zang
Summary: Facing the pressure of increasing population and climate degeneration, exploring a green and environmentally sustainable food source, especially for protein-enriched diets, is crucial. This review summarizes recent advances in walnut protein, including its geographical distribution, structural and physiochemical properties, and functional attributes. While walnut protein has high nutritional value and environmental friendliness, allergies and physicochemical limitations have raised concerns. Comprehensive analysis and discussion provide useful strategies for future research, extraction, and processing of walnut protein.
Review
Cell Biology
Juan Lu, Zhaoying Xiao, Mengqiu Xu, Lanjuan Li
Summary: LINC00346 has been found to function as an oncogene in several cancers and its expression level is significantly correlated with various clinical indicators. It regulates specific cellular functions by interacting with multiple molecules and signaling pathways. Researchers believe that LINC00346 may be a potential target for disease diagnosis and treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Immunology
Xingyu Zhai, Yunfei Zhang, Shuyu Xin, Pengfei Cao, Jianhong Lu
Summary: Circular RNAs (circRNAs) are abundant, stable RNA molecules with circular structures that can serve as biomarkers for various diseases. In the context of autoimmune diseases (AIDs), circRNAs offer new possibilities for diagnosis and treatment by impacting the pathophysiological processes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Adriana Trifan, Andra-Cristina Bostanaru, Simon Vlad Luca, Veronika Temml, Muhammad Akram, Sonja Herdlinger, Lukasz Kulinowski, Krystyna Skalicka-Wozniak, Sebastian Granica, Monika E. Czerwinska, Aleksandra Kruk, Helene Greige-Gerges, Mihai Mares, Daniela Schuster
Summary: This study found that honokiol and magnolol have high activity against dermatophyte infections, acting as fungicidal agents through inhibition of ergosterol biosynthesis. Synergistic effects were observed when magnolol was combined with terbinafine, while honokiol only showed additive effects. Additionally, magnolol displayed inhibitory effects on pro-inflammatory cytokines released by stimulated human neutrophils.
Article
Construction & Building Technology
Benjamin Madeja, Denis Gebauer, Maximilian R. Marsiske, Andreas Ott, Markus Rueckel, Rose Rosenberg, Annet Baken, Tomasz M. Stawski, Alejandro Fernandez-Martinez, Alexander E. S. Van Driessche, Helmut Coelfen, Matthias Kellermeier
Summary: In this study, the formation of calcium hydroxide crystals from supersaturated aqueous solutions was investigated. Experimental data showed that calcium hydroxide started with ion association and cluster formation, leading to the formation of amorphous nanoparticles. These nanoparticles then aggregated, forming networks that eventually transformed into hexagonal Ca(OH)2 crystals. The presence of a soluble polycarboxylate delayed the transition to the final crystalline phase.
CEMENT AND CONCRETE RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xing'an Dong, Zhihao Cui, Xian Shi, Ping Yan, Zhiming Wang, Anne C. Co, Fan Dong
Summary: This study reveals the light-dependent surface hydrogenation mechanism and light-independent protection of catalyst surface on ultrathin Bi4O5Br2 nanosheets, providing a new strategy for advancing sustainable ammonia production through photocatalytic N-2 reduction.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biotechnology & Applied Microbiology
Hafiz Ishfaq Ahmad, Nabeel Ijaz, Gulnaz Afzal, Akhtar Rasool Asif, Aziz Ur Rehman, Abdur Rahman, Irfan Ahmed, Muhammad Yousaf, Abdelmotaleb Elokil, Sayyed Aun Muhammad, Sarah M. Albogami, Saqer S. Alotaibi
Summary: This study aims to determine the pathogenic effect of variations in BMP genes on BMP protein function. Computational analysis and molecular modeling revealed the impact of certain variations on the function and structure of BMP proteins.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Cell Biology
Raju Dash, Md Chayan Ali, Israt Jahan, Yeasmin Akter Munni, Sarmistha Mitra, Md Abdul Hannan, Binod Timalsina, Diyah Fatimah Oktaviani, Ho Jin Choi, Il Soo Moon
Summary: CBD, a non-psychotropic phytocannabinoid, has shown potential therapeutic implications in neurodegenerative disorders by modulating the proteostasis network. It has neuroprotective effects and can clear protein aggregates, offering a new therapeutic window for age-associated proteinopathies.
AGEING RESEARCH REVIEWS
(2021)
Article
Biology
Yeasmin Akter Munni, Md Chayan Ali, Nusrat Jahan Selsi, Marium Sultana, Md Hossen, Tanjiba Harun Bipasha, Mahbubur Rahman, Md Nazim Uddin, S. M. Zahid Hosen, Raju Dash
Summary: The study used molecular modeling techniques to investigate the binding behaviors of SHK and its derivatives with VEGFR-2, revealing the importance of the naphthazarin ring for strong binding and the potential modulations of binding stability through side chain modifications.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Raju Dash, Israt Jahan, Md. Chayan Ali, Sarmistha Mitra, Yeasmin Akter Munni, Binod Timalsina, Md. Abdul Hannan, Il Soo Moon
Summary: This article discusses the relationship between proteostasis and proteinopathies, as well as the effectiveness of using phytochemicals to modulate proteostasis. Modulating proteostasis targeting proteinopathies may be an effective way to prevent the progression of neurodegenerative diseases.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Md Abdul Hannan, Md Nazmul Haque, Yeasmin Akter Munni, Diyah Fatimah Oktaviani, Binod Timalsina, Raju Dash, Tania Afrin, Il Soo Moon
Summary: This study aimed to investigate the effects of Centella asiatica and its active component asiatic acid on various stages of neuronal polarity. The results showed that CAE enhanced neurite outgrowth, dendritic and axonal morphology, and facilitated synapse formation, indicating its neurotrophic function. Asiatic acid also promoted neurite outgrowth, but to a lesser extent compared to CAE.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Raju Dash, Sarmistha Mitra, Yeasmin Akter Munni, Ho Jin Choi, Md Chayan Ali, Largess Barua, Tae Jung Jang, Il Soo Moon
Summary: This study identified four damaging variants in the NAGK gene, located in different structural domains, which induce significant alterations in structure and function. These variants were found to reduce the binding energy between NAGK and the dynein subunit DYNLRB1, impacting their non-canonical function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Md Chayan Ali, Mst Shanzeda Khatun, Sultana Israt Jahan, Raju Das, Yeasmin Akter Munni, Md Mafizur Rahman, Raju Dash
Summary: This study aimed to design an effective epitope-based peptide vaccine against NTS species, utilizing immunoinformatics and molecular modeling approaches, to identify promising T and B cell epitopes and construct a multiepitope vaccine with good affinity and stability. In silico immune simulation showed a strong immune response, suggesting the potential of the predicted vaccine constructs as candidates against common NTS species.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Review
Nutrition & Dietetics
Md. Abdul Hannan, Md. Ataur Rahman, Abdullah Al Mamun Sohag, Md. Jamal Uddin, Raju Dash, Mahmudul Hasan Sikder, Md. Saidur Rahman, Binod Timalsina, Yeasmin Akter Munni, Partha Protim Sarker, Mahboob Alam, Md. Mohibbullah, Md. Nazmul Haque, Israt Jahan, Md. Tahmeed Hossain, Tania Afrin, Md. Mahbubur Rahman, Md. Tahjib-Ul-Arif, Sarmistha Mitra, Diyah Fatimah Oktaviani, Md Kawsar Khan, Ho Jin Choi, Il Soo Moon, Bonglee Kim
Summary: Black cumin is considered a functional food with a wide array of health benefits, including antioxidant, anti-inflammatory, immunomodulatory, and cell survival-promoting effects. Its active component TQ has demonstrated potential roles in various diseases and anti-cancer properties. Despite significant advances, black cumin and TQ are still far from clinical application.
Review
Neurosciences
Sarmistha Mitra, Raju Dash, Md. Sohel, Apusi Chowdhury, Yeasmin Akter Munni, Chayan Ali, Md. Abdul Hannan, Tofazzal Islam, Il Soo Moon
Summary: Radiation therapy is effective in treating cancer, but it can cause side effects, including cognitive impairment. Estrogen, known for its neuroprotective activity, has been suggested as a potential approach to manage radiation-induced brain degeneration. This review summarizes the molecular mechanisms and the protective effects of phytoestrogens in radiation-induced brain injury.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Armin Sultana, Il Soo Moon
Summary: This study explores the mechanism of action of Withania somnifera (WS) on neuritogenesis and finds that it promotes neuronal growth. Additionally, WS was observed to modulate the neurotrophin signaling pathway and steroidal lactones in WS might act as nerve growth factor (NGF)-mimetics. These findings suggest the potential of WS as a therapeutic agent for memory-related neurological disorders.
PHYTOTHERAPY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Sarmistha Mitra, Raju Dash, Yeasmin Akter Munni, Nusrat Jahan Selsi, Nasrin Akter, Md Nazim Uddin, Kishor Mazumder, Il Soo Moon
Summary: This review discusses an alternative strategy for managing GBM and neurodegeneration by targeting heat shock protein 90 (Hsp90), which plays essential roles in protein folding and signaling regulation. The benefits of Hsp90 inhibition in cancer treatment are well-known, and recent evidence suggests their potential applications in GBM and neurodegenerative diseases.
Article
Plant Sciences
Yeasmin Akter Munni, Raju Dash, Sarmistha Mitra, Nayan Dash, Mutakabrun Shima, Il Soo Moon
Summary: This study found that Coriandrum sativum extract can promote synaptogenesis and neuronal growth, potentially through the neurotrophin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Biology
Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Toma Sadhu, Largess Barua, Md. Ariful Islam, Dipannita Chowdhury, Debpriya Bhattacharjee, Kishor Mazumder, Il Soo Moon
Summary: The gut microbiota and the brain are interconnected through a complex bidirectional network. Intestinal homeostasis is crucial for brain function and plays a significant role in disease progression. The relationship between neuropsychological behavior, neurodegeneration, and gut dysbiosis is established, but many pathways are still unknown.
Article
Biochemistry & Molecular Biology
Yeasmin Akter Munni, Raju Dash, Ho Jin Choi, Sarmistha Mitra, Md. Abdul Hannan, Kishor Mazumder, Binod Timalsina, Il Soo Moon
Summary: Garlic extracts, both processed and unprocessed, have been found to promote the maturation of hippocampal neurons and the formation of functional synapses. The compound linalool, found in both extracts, plays a role in promoting neurite outgrowth and has a modulatory effect on neurotrophic signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ho Jin Choi, Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Sarmin Ummey Habiba, Md Sohel, Sultana Israt Jahan, Tae Jung Jang, Il Soo Moon
Summary: Disruptive neuronal migration during early brain development can cause severe brain malformation. This study identified high-risk nsSNPs in the LIS1 gene through bioinformatics and molecular modeling, and demonstrated their impact on the loss of LIS1 function through molecular dynamics simulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)