Review
Biochemistry & Molecular Biology
Jun Ho Lee, Hong Jun Kim, Jong Uk Kim, Tae Han Yook, Kyeong Han Kim, Joo Young Lee, Gabsik Yang
Summary: Alzheimer's disease and Parkinson's disease, the most common neurodegenerative diseases, are associated with the release of NLRP3 inflammasome-mediated proinflammatory cytokines by the excessive activation of microglia. Although studies suggest that the NLRP3 inflammasome plays an important role in disease development, its exact function and regulation are still unclear. Studies on natural products show promise as a potential strategy for treating these diseases by regulating NLRP3 inflammasome assembly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bruno Permanne, Astrid Sand, Solenne Ousson, Maud Neny, Jennifer Hantson, Ryan Schubert, Christoph Wiessner, Anna Quattropani, Dirk Beher
Summary: Neurodegenerative proteinopathies are characterized by the intracellular formation of insoluble and toxic protein aggregates in the brain that are closely linked to disease progression. In this study, the inhibition of OGA was found to prevent the aggregation and toxicity of tau and alpha-synuclein, suggesting its potential as a therapeutic approach. The novel OGA inhibitor ASN90 demonstrated promising preclinical results, preventing tau pathology, improving motor behavior and survival, and reducing astrogliosis in mouse models.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Shin Jie Yong, Abhimanyu Veerakumarasivam, Wei Ling Lim, Jactty Chew
Summary: Recent research on lactoferrin has revealed its multifunctional roles as an antimicrobial protein, immunomodulatory agent, anticancer agent, and neuroprotective agent. This literature review focuses on lactoferrin's neuroprotective effects and mechanisms against Alzheimer's and Parkinson's diseases, highlighting the involvement of various cellular pathways and proteins. It also discusses the inconsistent findings related to the neuroprotective effects of lactoferrin against Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Hui-Zhi Long, Yan Cheng, Zi-Wei Zhou, Hong-Yu Luo, Dan-Dan Wen, Li-Chen Gao
Summary: Alzheimer's disease and Parkinson's disease are two typical neurodegenerative diseases that increase with aging, and are related to the PI3K/AKT signaling pathway. Natural products can play a neuroprotective role by activating this pathway, potentially serving as a source for disease treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Behavioral Sciences
Ashok Jangra, Mehak Verma, Deepak Kumar, Chandrika, Mahesh Rachamalla, Abhijit Dey, Kamal Dua, Saurabh Kumar Jha, Shreesh Ojha, Athanasios Alexiou, Dinesh Kumar, Niraj Kumar Jha
Summary: The primary aim of this review is to summarize the literature on natural products that target endoplasmic reticulum stress (ERS) for the treatment of various neurological disorders. ERS has been implicated in the pathogenesis of multiple neurological disorders, and several natural products targeting ERS signaling pathways have potential neuroprotective properties.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Review
Geriatrics & Gerontology
Jing Yang, Wei Zhang, Shugeng Zhang, Ashok Iyaswamy, Jichao Sun, Jigang Wang, Chuanbin Yang
Summary: A key feature of neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of misfolded protein aggregates, which have limited effective therapeutic agents. TFEB, a regulator of lysosomal biogenesis and autophagy, plays a crucial role in protein aggregate degradation and is regarded as a promising therapeutic target for these NDs.
Article
Cell Biology
Tiejian Nie, Kai Tao, Lin Zhu, Lu Huang, Sijun Hu, Ruixin Yang, Pingyi Xu, Zixu Mao, Qian Yang
Summary: This study demonstrates the critical role of chaperone-mediated autophagy (CMA) in maintaining proper mitochondria dynamics. Loss of this regulatory control may occur in Parkinson's disease (PD), leading to impaired mitochondria function. Increasing CMA activity promotes MARCHF5 turnover, reduces mitochondria fragmentation, and alleviates mitochondrial dysfunction under oxidative stress.
Article
Biochemistry & Molecular Biology
Julia D. Vavilova, Anna A. Boyko, Natalya Troyanova, Natalya Ponomareva, Vitaly F. Fokin, Ekaterina Y. Fedotova, Maria A. Streltsova, Sofya A. Kust, Maria Grechikhina, Olga A. Shustova, Tatyana L. Azhikina, Elena Kovalenko, Alexander M. Sapozhnikov
Summary: Parkinson's disease is a proteostasis disorder caused by the accumulation of alpha-synuclein in a specific brain region. This study examined the changes in chaperones and p62 protein levels in peripheral blood mononuclear cells (PBMC) of PD patients. While there were no changes in the intracellular HSP70 protein pool, increased transcriptional activity of stress-associated genes and elevated p62 levels were observed. The combination of HSPA6 and p62 markers showed diagnostic significance with intermediate sensitivity and high specificity for PD patients.
Review
Cell Biology
Danielle Cozachenco, Felipe C. Ribeiro, Sergio T. Ferreira
Summary: The homeostasis of cellular proteins, or proteostasis, is crucial for neuronal function and brain processes, including learning and memory. Defective proteostasis has been found to contribute to the progression of Alzheimer's disease, the most common form of dementia in the elderly. This article discusses the molecular pathways involved in protein synthesis and degradation that are altered in Alzheimer's disease, as well as potential pharmacological approaches to correct these defects.
AGEING RESEARCH REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Esra Kupeli Akkol, Irem Tatli Cankaya, Gokce Seker Karatoprak, Elif Carpar, Eduardo Sobarzo-Sanchez, Raffaele Capasso
Summary: Psychiatric disorders are often comorbid with neurological diseases, with depression and anxiety being the most common diagnoses that are often overlooked. While there are various treatment options available, oral antidepressant therapy may have disadvantages. Research has shown that natural compounds of plant origin have potential in the treatment of psychiatric disorders.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Raju Dash, Md Chayan Ali, Israt Jahan, Yeasmin Akter Munni, Sarmistha Mitra, Md Abdul Hannan, Binod Timalsina, Diyah Fatimah Oktaviani, Ho Jin Choi, Il Soo Moon
Summary: CBD, a non-psychotropic phytocannabinoid, has shown potential therapeutic implications in neurodegenerative disorders by modulating the proteostasis network. It has neuroprotective effects and can clear protein aggregates, offering a new therapeutic window for age-associated proteinopathies.
AGEING RESEARCH REVIEWS
(2021)
Review
Multidisciplinary Sciences
Abolaji Samson Olagunju, Foysal Ahammad, Abiola Adeyanju Alagbe, Titilayomi Ayomide Otenaike, John Oluwafemi Teibo, Farhan Mohammad, Ahad Amer Alsaiari, Olabode Omotoso, Md Enamul Kabir Talukder
Summary: Mitochondrial dysfunction plays a crucial role in various neurodegenerative diseases. Changes in mitochondrial homeostasis are associated with the onset of Alzheimer's and Parkinson's diseases. Early mitochondrial dysfunctions may contribute to the progression of neuropathological processes.
Review
Plant Sciences
Mukta Gupta, Naresh Singh, Balbir Singh, Perwez Alam
Summary: This review summarizes the clinical and preclinical studies on the use of plant-derived active compounds for the treatment of Huntington's disease. These natural products exhibit anti-Huntington effects by targeting enzymes, modulating inflammatory mediators, and/or improving cognitive impairment. Although some preclinical studies have shown promising effects of phytochemicals in the treatment of Huntington's disease, further research is needed to prove their efficacy and safety in humans.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Neurosciences
James F. Striebel, Brent Race, Jacqueline M. Leung, Cindi Schwartz, Bruce Chesebro
Summary: Accumulation of misfolded host proteins, like PrPSc, in the retina during prion infection leads to early damage to the inner segments of photoreceptor cells and eventual death. Neurons in the outer plexiform layer are selectively targeted by prion deposition, with loss of ribbon synapses preceding widespread destruction of rods and cones.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Review
Medicine, Research & Experimental
Meijun Pang, Rui Peng, Yiwen Wang, Yi Zhu, Peng Wang, Bernard Moussian, Yanfang Su, Xiuyun Liu, Dong Ming
Summary: Parkinson's disease is a common neurodegenerative disease that primarily affects the elderly population. The current treatment options for Parkinson's disease have significant side effects and reduced effectiveness over time. Plant compounds have shown potential as a less toxic treatment option.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Neurosciences
Sarmistha Mitra, Raju Dash, Md. Sohel, Apusi Chowdhury, Yeasmin Akter Munni, Chayan Ali, Md. Abdul Hannan, Tofazzal Islam, Il Soo Moon
Summary: Radiation therapy is effective in treating cancer, but it can cause side effects, including cognitive impairment. Estrogen, known for its neuroprotective activity, has been suggested as a potential approach to manage radiation-induced brain degeneration. This review summarizes the molecular mechanisms and the protective effects of phytoestrogens in radiation-induced brain injury.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Neurosciences
Md. Mohibbullah, Michael Yordan Pringgo Wicaksono, Md. Abdul Hannan, Raju Dash, Maria Dyah Nur Meinita, Jae-Suk Choi, Yong-Ki Hong, Il Soo Moon
Summary: This study aimed to investigate the protective effects of Gelidium amansii extract (GAE) against scopolamine-induced cognitive deficits and its modulatory effects on hippocampal plasticity in mice. The results showed that GAE administration significantly improved memory deficits in mice, as indicated by increased latency time on the passive avoidance test and decreased errors and latency time on the radial arm maze test. Microscopic observations and immunohistochemistry analysis also revealed improved spine density, synaptic contact, and the recruitment of memory-associated proteins in GAE-treated mice. These findings suggest that GAE could be a potential functional food and a promising source of pharmacological agents for memory-related brain disorders.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Article
Multidisciplinary Sciences
Brian M. Romero, Stephany Vilchez-Bravo, Gustavo Hernandez-Arriaga, Lotty Bueso-Pineda, Thomas Franchi, Marcos Roberto Tovani-Palone, Christian R. Mejia
Summary: This study aimed to determine the factors associated with complications of foreign body ingestion and/or aspiration in children from a hospital in the Peruvian social security program. The most frequently ingested foreign bodies were coins, but complications were more common in cases of battery ingestion and in those where the diagnosis was made after 8 hours.
Review
Multidisciplinary Sciences
Shankargouda Patil, Shilpa Bhandi, Mohammed Mousa H. Bakri, Dhalia H. Albar, Khalid J. Alzahrani, Mohammad S. Al-Ghamdi, Mrim M. Alnfiai, Marcos Roberto Tovani-Palone
Summary: Patients with prolonged edentulism face challenges in replacing missing teeth. The use of non-resorbable and resorbable membranes in guided bone regeneration showed similar efficacy. However, further research is needed to draw conclusive results due to the low quality of evidence.
Review
Computer Science, Theory & Methods
Md. Abdul Hannan, Md. Atik Shahriar, Md Sadek Ferdous, Mohammad Jabed Morshed Chowdhury, Mohammad Shahriar Rahman
Summary: KYC guidelines require financial institutions to verify identity, suitability, and assess risks while maintaining a business relationship. e-KYC provides convenience and transparency through digitalization, but issues like lack of standardization, fraudulent activities, and privacy concerns need to be addressed. Blockchain has potential to address these issues, and several research works have explored the intersection of e-KYC and blockchain.
Article
Biochemistry & Molecular Biology
Binod Timalsina, Md Nazmul Haque, Raju Dash, Ho Jin Choi, Nisha Ghimire, Il Soo Moon
Summary: TASE and thymol have potent capacities in promoting neuronal development and reconstruction, which are crucial for neurodegenerative disorders and acute brain injuries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yeasmin Akter Munni, Raju Dash, Sarmistha Mitra, Nayan Dash, Mutakabrun Shima, Il Soo Moon
Summary: This study found that Coriandrum sativum extract can promote synaptogenesis and neuronal growth, potentially through the neurotrophin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Binod Timalsina, Md Nazmul Haque, Ho Jin Choi, Raju Dash, Il Soo Moon
Summary: This study investigates the therapeutic potential of Tachyspermum ammi seed extract (TASE) and its principal component thymol for the treatment of Alzheimer's disease (AD) in a mouse model. The findings suggest that TASE and thymol can reduce oxidative stress, enhance learning and memory, decrease A beta 1-42 accumulation, and promote neurogenesis, indicating their potential as natural therapeutic agents for neurodegenerative disorders.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biology
Sarmistha Mitra, Yeasmin Akter Munni, Raju Dash, Toma Sadhu, Largess Barua, Md. Ariful Islam, Dipannita Chowdhury, Debpriya Bhattacharjee, Kishor Mazumder, Il Soo Moon
Summary: The gut microbiota and the brain are interconnected through a complex bidirectional network. Intestinal homeostasis is crucial for brain function and plays a significant role in disease progression. The relationship between neuropsychological behavior, neurodegeneration, and gut dysbiosis is established, but many pathways are still unknown.
Article
Biochemistry & Molecular Biology
Yeasmin Akter Munni, Raju Dash, Ho Jin Choi, Sarmistha Mitra, Md. Abdul Hannan, Kishor Mazumder, Binod Timalsina, Il Soo Moon
Summary: Garlic extracts, both processed and unprocessed, have been found to promote the maturation of hippocampal neurons and the formation of functional synapses. The compound linalool, found in both extracts, plays a role in promoting neurite outgrowth and has a modulatory effect on neurotrophic signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Binod Timalsina, Ho Jin Choi, Il Soo Moon
Summary: In this study, the researchers explored the role of N-acetylglucosamine kinase (NAGK) and small nuclear ribonucleoprotein polypeptide N (SNRPN) in neurodevelopment. They found that the interaction of NAGK and SNRPN promotes axodendritic development of neurons and is associated with the DYNLRB1 protein. Additionally, the NAGK and SNRPN proteins were found to rescue impaired axodendritic development in a Prader-Willi syndrome (PWS) model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Rajib Dhar, Arikketh Devi, Shankargouda Patil, Marcos Roberto Tovani-Palone
Summary: This article discusses the involvement of exosomes, a subpopulation of extracellular vesicles secreted by cells in normal or pathological conditions, in cancer progression and their potential as a therapeutic tool based on their molecular signature for investigating cancer biomarkers. Recent research also reveals the potential role of exosomes in anticancer drug delivery and their future orientation in theranostics perspectives.
ELECTRONIC JOURNAL OF GENERAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)