Reducing White Adipose Tissue Browning Using p38α MAPK Inhibitors Ameliorates Cancer-Associated Cachexia as Assessed by Magnetic Resonance Imaging

Development of ovarian tumour causes significant loss of muscle and adipose tissue: a novel mouse model for cancer cachexia study

(2022) Yi Luan et al.   Journal of Cachexia Sarcopenia and Muscle

Whole‐body and adipose tissue metabolic phenotype in cancer patients

(2022) Lindsey J. Anderson et al.   Journal of Cachexia Sarcopenia and Muscle

MAPK-Activated Protein Kinases: Servant or Partner?

(2022) Natalia Ronkina et al.   Annual Review of Biochemistry

Piceatannol, a Dietary Polyphenol, Alleviates Adipose Tissue Loss in Pre-Clinical Model of Cancer-Associated Cachexia via Lipolysis Inhibition

(2022) Jonathan C. Kershaw et al.   Nutrients

Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging

(2021) Yue Chen et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Carnosol and its analogues attenuate muscle atrophy and fat lipolysis induced by cancer cachexia

(2021) Shanshan Lu et al.   Journal of Cachexia Sarcopenia and Muscle

HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes

(2021) Xin Lv et al.   Aging-US

Synergistic interventional photothermal therapy and immunotherapy using an iron oxide nanoplatform for the treatment of pancreatic cancer

(2021) Meng Wang et al.   Acta Biomaterialia

Development of metabolic and contractile alterations in development of cancer cachexia in female tumor-bearing mice

(2021) Seongkyun Lim et al.   JOURNAL OF APPLIED PHYSIOLOGY

Alantolactone ameliorates cancer cachexia-associated muscle atrophy mainly by inhibiting the STAT3 signaling pathway

(2021) Qiang Shen et al.   PHYTOMEDICINE

Histomorphological and inflammatory changes of white adipose tissue in gastrointestinal cancer patients with and without cachexia

(2021) Alessio Molfino et al.   Journal of Cachexia Sarcopenia and Muscle

Combination of PD1 Inhibitor and OX40 Agonist Induces Tumor Rejection and Immune Memory in Mouse Models of Pancreatic Cancer

(2020) Ying Ma et al.   GASTROENTEROLOGY

Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

(2020) Xin Huang et al.   Clinical and Translational Medicine

Brown fat does not cause cachexia in cancer patients: A large retrospective longitudinal FDG-PET/CT cohort study

(2020) Anton S. Becker et al.   PLoS One

The Extract of Arctium lappa L. Fruit (Arctii Fructus) Improves Cancer-Induced Cachexia by Inhibiting Weight Loss of Skeletal Muscle and Adipose Tissue

(2020) Yo-Han Han et al.   Nutrients

Impact of Conventional and Atypical MAPKs on the Development of Metabolic Diseases

(2020) Toufic Kassouf et al.   Biomolecules

Phases of Metabolic and Soft Tissue Changes in Months Preceding a Diagnosis of Pancreatic Ductal Adenocarcinoma

(2019) Raghuwansh P. Sah et al.   GASTROENTEROLOGY

Higher tumor mass and lower adipose mass are associated with colon‑26 adenocarcinoma‑induced cachexia in male, female and ovariectomized mice

(2019) Taylor Banh et al.   ONCOLOGY REPORTS

Effects of VCP979 Novel p38 Mitogen Activated Protein Kinase Inhibitor on Progression of Pancreatic Cancer in Mouse Model with Diabetic Conditions

(2019) Tingting Xu et al.   Journal of Biomedical Nanotechnology

A novel small molecule compound VCP979 improves ventricular remodeling in murine models of myocardial ischemia/reperfusion injury

(2019) Jing Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Metformin prevents the pathological browning of subcutaneous white adipose tissue

(2019) Christopher Auger et al.   Molecular Metabolism

p38α Mitogen-Activated Protein Kinase Is a Druggable Target in Pancreatic Adenocarcinoma

(2019) Ling Yang et al.   Frontiers in Oncology

Brown and beige fat: From molecules to physiology and pathophysiology

(2018) Stefania Carobbio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Non-invasive methods for the assessment of brown adipose tissue in humans

(2018) Maria Chondronikola et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic benefits of inhibition of p38α in white adipose tissue in obesity

(2018) Shengjie Zhang et al.   PLOS BIOLOGY

p38α blocks brown adipose tissue thermogenesis through p38δ inhibition

(2018) Nuria Matesanz et al.   PLOS BIOLOGY

Three cachexia phenotypes and the impact of fat-only loss on survival in FOLFIRINOX therapy for pancreatic cancer

(2018) Joshua K. Kays et al.   Journal of Cachexia Sarcopenia and Muscle

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Toll-Like Receptor-4 Disruption Suppresses Adipose Tissue Remodeling and Increases Survival in Cancer Cachexia Syndrome

(2018) Felipe Henriques et al.   Scientific Reports

Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma

(2017) Yangchun Xie et al.   GASTROENTEROLOGY

Exosomal adrenomedullin derived from cancer-associated fibroblasts promotes lipolysis in adipose tissue

(2017) Fanyang Kong et al.   GUT

The use of magnetic resonance imaging to characterize abnormal body composition phenotypes in youth with Prader–Willi syndrome

(2017) Camila E. Orsso et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis

(2017) Chunxiao Miao et al.   Frontiers in Pharmacology

An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice

(2016) Maria Rohm et al.   NATURE MEDICINE

Transcriptional and epigenetic control of brown and beige adipose cell fate and function

(2016) Takeshi Inagaki et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

White Adipose Tissue Browning: A Double-edged Sword

(2016) Abdikarim Abdullahi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Brown, Beige, and White: The New Color Code of Fat and Its Pharmacological Implications

(2015) Alexander Pfeifer et al.   Annual Review of Pharmacology and Toxicology

Stress kinases in the modulation of metabolism and energy balance

(2015) Elisa Manieri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

A Switch from White to Brown Fat Increases Energy Expenditure in Cancer-Associated Cachexia

(2014) Michele Petruzzelli et al.   Cell Metabolism

Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

(2014) Serkan Kir et al.   NATURE

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK

(2014) Natalie B. Vinh et al.   ChemistryOpen

Comparison of brown and white adipose tissue fat fractions in ob, seipin, and Fsp27 gene knockout mice by chemical shift-selective imaging and 1H-MR spectroscopy

(2012) Xin-Gui Peng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Understanding the mechanisms and treatment options in cancer cachexia

(2012) Kenneth Fearon et al.   Nature Reviews Clinical Oncology

Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update

(2012) John M. Kyriakis et al.   PHYSIOLOGICAL REVIEWS

Adipogenesis

(2012) K. Sarjeant et al.   Cold Spring Harbor Perspectives in Biology

Quantification of liver fat in mice: comparing dual-echo Dixon imaging, chemical shift imaging, and 1H-MR spectroscopy

(2011) Xin-Gui Peng et al.   JOURNAL OF LIPID RESEARCH

Definition and classification of cancer cachexia: an international consensus

(2011) Kenneth Fearon et al.   LANCET ONCOLOGY

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Regulation of adipogenesis by medium-chain fatty acids in the absence of hormonal cocktail☆

(2008) Jeong-Yeh Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY