Oxidative stress induces monocyte‐to‐myofibroblast transdifferentiation through p38 in pancreatic ductal adenocarcinoma

Induced CD10 expression during monocyte-to-macrophage differentiation identifies a unique subset of macrophages in pancreatic ductal adenocarcinoma

(2020) Xin Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reactive oxygen species-mediated cytoplasmic stiffening impairs the phagocytic ability of the macrophage

(2020) Mahesh Agarwal et al.   JOURNAL OF CELL SCIENCE

Fibroblast Heterogeneity in the Pancreatic Tumor Microenvironment

(2020) Erin Helms et al.   Cancer Discovery

Cancer statistics, 2019

(2019) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

(2019) Cecilia Roux et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Current Status of Immunotherapies for Treating Pancreatic Cancer

(2019) Annie A. Wu et al.   Current Oncology Reports

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

Checkpoint inhibitors in pancreatic cancer

(2019) Andreas Henriksen et al.   CANCER TREATMENT REVIEWS

Meta-analysis comparing upfront surgery with neoadjuvant treatment in patients with resectable or borderline resectable pancreatic cancer

(2018) E. Versteijne et al.   BRITISH JOURNAL OF SURGERY

CD10 + GPR77 + Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness

(2018) Shicheng Su et al.   CELL

Transdifferentiation of human adult peripheral blood T cells into neurons

(2018) Koji Tanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma

(2018) Huilin Ye et al.   Cell Death & Disease

PARP inhibitor olaparib sensitizes cholangiocarcinoma cells to radiation

(2018) Yize Mao et al.   Cancer Medicine

Transdifferentiation of Human Circulating Monocytes Into Neuronal-Like Cells in 20 Days and Without Reprograming

(2018) Alfredo Bellon et al.   Frontiers in Molecular Neuroscience

Immune Cell and Stromal Signature Associated With Progression-Free Survival of Patients With Resected Pancreatic Ductal Adenocarcinoma

(2018) Ujjwal Mukund Mahajan et al.   GASTROENTEROLOGY

Turning foes to friends: targeting cancer-associated fibroblasts

(2018) Xueman Chen et al.   NATURE REVIEWS DRUG DISCOVERY

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Tissue-Resident Macrophages in Pancreatic Ductal Adenocarcinoma Originate from Embryonic Hematopoiesis and Promote Tumor Progression

(2017) Yu Zhu et al.   IMMUNITY

Targeting stroma in pancreatic cancer: Promises and failures of targeted therapies

(2017) Afsane Bahrami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tissue factor variants induce monocyte transformation and transdifferentiation into endothelial cell-like cells

(2017) G. Arderiu et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tumor macrophages are pivotal constructors of tumor collagenous matrix

(2016) Ran Afik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypoxia and macrophages promote glioblastoma invasion by the CCL4-CCR5 axis

(2016) Ying Wang et al.   ONCOLOGY REPORTS

GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer

(2016) M. Waghray et al.   Cancer Discovery

Ballgown bridges the gap between transcriptome assembly and expression analysis

(2015) Alyssa C Frazee et al.   NATURE BIOTECHNOLOGY

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages

(2014) Julie M. Lowe et al.   CANCER RESEARCH

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function

(2014) R. Wunderlich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma

(2014) E. J. Kim et al.   CLINICAL CANCER RESEARCH

Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway

(2014) SUN-YOUNG LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage–stellate cell interaction

(2014) Chanjuan Shi et al.   LABORATORY INVESTIGATION

Macrophages promote renal fibrosis through direct and indirect mechanisms

(2014) David J. Nikolic-Paterson et al.   Kidney International Supplements

ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages

(2013) Yan Zhang et al.   CELL RESEARCH

Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer

(2013) Julia Tchou et al.   HUMAN PATHOLOGY

ERK1/2 activation mediated by the nutlin-3-induced mitochondrial translocation of p53

(2013) SUN-YOUNG LEE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

(2013) Maria Pia Protti et al.   Frontiers in Physiology

Nutlin-3, a small-molecule MDM2 inhibitor, sensitizes Caki cells to TRAIL-induced apoptosis through p53-mediated PUMA upregulation and ROS-mediated DR5 upregulation

(2012) Eun Jung Park et al.   ANTI-CANCER DRUGS

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Activation of the p53 pathway induces α-smooth muscle actin expression in both myeloid leukemic cells and normal macrophages

(2011) Paola Secchiero et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

(2011) Chris Jopling et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

(2011) M. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCAAT/enhancer binding protein   (C/EBP )-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation

(2011) A. Di Tullio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress promotes myofibroblast differentiation and tumour spreading

(2010) Aurore Toullec et al.   EMBO Molecular Medicine

CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer

(2010) Naoki Ikenaga et al.   GASTROENTEROLOGY

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Redox Regulation of Cell Survival

(2008) Dunyaporn Trachootham et al.   ANTIOXIDANTS & REDOX SIGNALING

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

The Activated Stroma Index Is a Novel and Independent Prognostic Marker in Pancreatic Ductal Adenocarcinoma

(2008) Mert Erkan et al.   Clinical Gastroenterology and Hepatology

Mapping and quantifying mammalian transcriptomes by RNA-Seq

(2008) Ali Mortazavi et al.   NATURE METHODS

PU.1 and C/EBP /  convert fibroblasts into macrophage-like cells

(2008) R. Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA