The Assembly Factor SDHAF2 Is Dispensable for Flavination of the Catalytic Subunit of Mitochondrial Complex II in Breast Cancer Cells

In-vitro, SDH5-dependent flavinylation of immobilized human respiratory complex II flavoprotein

(2016) Lala Zafreen et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB

(2016) Nunziata Maio et al.   Cell Metabolism

Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner

(2015) Bing Yan et al.   BMC CANCER

Mitochondrial Genome Acquisition Restores Respiratory Function and Tumorigenic Potential of Cancer Cells without Mitochondrial DNA

(2015) An S. Tan et al.   Cell Metabolism

Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II

(2015) Elena Maklashina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation

(2015) K Kluckova et al.   Cell Death & Disease

Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation

(2015) Anjali K. Nath et al.   Cell Reports

LON is the master protease that protects against protein aggregation in human mitochondria through direct degradation of misfolded proteins

(2015) Ayenachew Bezawork-Geleta et al.   Scientific Reports

ROS-Triggered Phosphorylation of Complex II by Fgr Kinase Regulates Cellular Adaptation to Fuel Use

(2014) Rebeca Acín-Pérez et al.   Cell Metabolism

Protein-mediated assembly of succinate dehydrogenase and its cofactors

(2014) Jonathan G. Van Vranken et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mitochondrial matrix proteostasis is linked to hereditary paraganglioma: LON-mediated turnover of the human flavinylation factor SDH5 is regulated by its interaction with SDHA

(2014) Ayenachew Bezawork-Geleta et al.   FASEB JOURNAL

Analysis of covalent flavinylation using thermostable succinate dehydrogenase fromThermus thermophilusandSulfolobus tokodaiilacking SdhE homologs

(2014) Asako Kounosu   FEBS LETTERS

Novel oncogene and tumor suppressor mutations inKITandPDGFRAwild type gastrointestinal stromal tumors revealed by next generation sequencing

(2014) Jaclyn Frances Hechtman et al.   GENES CHROMOSOMES & CANCER

Paraganglioma and phaeochromocytoma: from genetics to personalized medicine

(2014) Judith Favier et al.   Nature Reviews Endocrinology

The Conserved RGxxE Motif of the Bacterial FAD Assembly Factor SdhE Is Required for Succinate Dehydrogenase Flavinylation and Activity

(2013) Matthew B. McNeil et al.   BIOCHEMISTRY

Q-site inhibitor induced ROS production of mitochondrial complex II is attenuated by TCA cycle dicarboxylates

(2013) Ilka Siebels et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Succinate Dehydrogenase 5 (SDH5) Regulates Glycogen Synthase Kinase 3β-β-Catenin-mediated Lung Cancer Metastasis

(2013) Jun Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Solution NMR Structure of Yeast Succinate Dehydrogenase Flavinylation Factor Sdh5 Reveals a Putative Sdh1 Binding Site

(2012) Alexander Eletsky et al.   BIOCHEMISTRY

Respiratory chain complex II as general sensor for apoptosis

(2012) Stefan Grimm   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial complex II, a novel target for anti-cancer agents

(2012) Katarina Kluckova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

(2012) Antoine Italiano et al.   BMC CANCER

SdhE Is a Conserved Protein Required for Flavinylation of Succinate Dehydrogenase in Bacteria

(2012) Matthew B. McNeil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Complex II Can Generate Reactive Oxygen Species at High Rates in Both the Forward and Reverse Reactions

(2012) Casey L. Quinlan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase assembly factor 2 is needed for assembly and activity of mitochondrial complex II and for normal root elongation in Arabidopsis

(2012) Shaobai Huang et al.   PLANT JOURNAL

SDH mutations in cancer

(2011) Chiara Bardella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

(2010) Lan-Feng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy

(2009) Daniele Ghezzi et al.   NATURE GENETICS

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

(2008) L-F Dong et al.   ONCOGENE