The inflammasome pathway: A key player in ocular surface and anterior segment diseases

Role of Caspase-1 as a Biomarker of Ocular Surface Damage

(2022) Arianna Tovar et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

AIM2 in regulatory T cells restrains autoimmune diseases

(2021) Wei-Chun Chou et al.   NATURE

Airborne particulate matter (PM2.5) triggers ocular hypertension and glaucoma through pyroptosis

(2021) Liping Li et al.   Particle and Fibre Toxicology

TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells

(2021) Sofia Ranta-aho et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death

(2021) Angela Gomez et al.   EXPERIMENTAL EYE RESEARCH

Exosomes Derived From Mouse Adipose-derived Mesenchymal Stem Cells Alleviate BAC-induced Mouse Dry Eye Model Via Inhibiting NLRP3 Inflammasome

(2021) Guifang Wang et al.   OPHTHALMIC RESEARCH

Calcitriol Alleviates Hyperosmotic Stress-Induced Corneal Epithelial Cell Damage via Inhibiting the NLRP3–ASC–Caspase-1–GSDMD Pyroptosis Pathway in Dry Eye Disease

(2021) Jing Zhang et al.   Journal of Inflammation Research

NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly

(2021) Tingting Niu et al.   Nature Communications

Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease

(2020) Antonio Abbate et al.   CIRCULATION RESEARCH

IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis

(2020) Haritha L. Desu et al.   Journal of Neuroinflammation

The Role of NLRP3 Inflammasome Activation in the Epithelial to Mesenchymal Transition Process During the Fibrosis

(2020) Amani Abraheem Alsadiq Alyaseer et al.   Frontiers in Immunology

The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease

(2020) Xavier O. Scott et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP12- and NLRC4-mediated corneal epithelial pyroptosis is driven by GSDMD cleavage accompanied by IL-33 processing in dry eye

(2020) Hui Chen et al.   Ocular Surface

Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response

(2020) Luo Zhuo et al.   Biomed Research International

Clinicopathologic correlations of retrocorneal membranes associated with endothelial corneal graft failure.

(2020) Andrea Naranjo et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Role of the NLRP3 inflammasome in autoimmune diseases

(2020) Zhe Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets

(2020) Vaidya Govindarajan et al.   Journal of Neuroinflammation

Airborne particulate matter (PM2.5) triggers cornea inflammation and pyroptosis via NLRP3 activation

(2020) Liangliang Niu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich–Containing Family, Pyrin Domain–Containing-3) Inflammasome in Cardiovascular Disorders

(2019) Zheng Wang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury

(2019) Alexey Pronin et al.   Frontiers in Molecular Neuroscience

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

(2019) Pu Hong et al.   Journal of Neuroinflammation

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

Activation of P2X7R- NLRP3 pathway in Retinal microglia contribute to Retinal Ganglion Cells death in chronic ocular hypertension (COH)

(2019) Yujian Zhang et al.   EXPERIMENTAL EYE RESEARCH

Polydatin Inhibits NLRP3 Inflammasome in Dry Eye Disease by Attenuating Oxidative Stress and Inhibiting the NF-κB Pathway

(2019) Bongkyun Park et al.   Nutrients

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

(2018) Jacob Fulp et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammasomes: An emerging mechanism translating environmental toxicant exposure into neuroinflammation in Parkinson’s disease

(2018) Faith L Anderson et al.   TOXICOLOGICAL SCIENCES

The NLRP3 Inflammasome May Contribute to Pathologic Neovascularization in the Advanced Stages of Diabetic Retinopathy

(2018) Shyam S. Chaurasia et al.   Scientific Reports

Contribution of the inflammasome to inflammaging

(2018) Nancy H. Mejias et al.   Journal of Inflammation-London

NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development

(2018) Patricia Ahechu et al.   Frontiers in Immunology

Calcitriol inhibits ROS-NLRP3-IL-1β signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells

(2018) Yiqin Dai et al.   Redox Biology

Inflammasomes, the eye and anti-inflammasome therapy

(2017) P Yerramothu et al.   EYE

Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn

(2017) Fang Bian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye

(2017) Wei Chi et al.   JOURNAL OF AUTOIMMUNITY

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Therapeutics targeting the inflammasome after central nervous system injury

(2016) Juan Pablo de Rivero Vaccari et al.   Translational Research

NOD-Like Receptors in Infection, Immunity, and Diseases

(2016) Young Keun Kim et al.   YONSEI MEDICAL JOURNAL

Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector?

(2015) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

The inflammasome NLRP3 plays a protective role against a viral immunopathological lesion

(2015) Fernanda Gimenez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients

(2015) Liangliang Niu et al.   PLoS One

Reactive oxygen species activated NLRP3 inflammasomes prime environment-induced murine dry eye

(2014) Qinxiang Zheng et al.   EXPERIMENTAL EYE RESEARCH

Pattern recognition receptors and central nervous system repair

(2014) Kristina A. Kigerl et al.   EXPERIMENTAL NEUROLOGY

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

(2014) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Pyroptotic Neuronal Cell Death Mediated by the AIM2 Inflammasome

(2014) Stephanie E Adamczak et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Novel NLRP3/cryopyrin mutations and pro-inflammatory cytokine profiles in Behçet’s syndrome patients

(2013) Şahru Yüksel et al.   INTERNATIONAL IMMUNOLOGY

NLRC4 expression in intestinal epithelial cells mediates protection against an enteric pathogen

(2013) S Nordlander et al.   Mucosal Immunology

Silica induces NLRP3 inflammasome activation in human lung epithelial cells

(2013) Paul M Peeters et al.   Particle and Fibre Toxicology

Host Response and Bacterial Virulence Factor Expression in Pseudomonas aeruginosa and Streptococcus pneumoniae Corneal Ulcers

(2013) Rajapandian SivaGanesa Karthikeyan et al.   PLoS One

Staphylococcus aureus Activates the NLRP3 Inflammasome in Human and Rat Conjunctival Goblet Cells

(2013) Victoria E. McGilligan et al.   PLoS One

P2X4 Receptors Influence Inflammasome Activation after Spinal Cord Injury

(2012) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

The NLRP3 inflammasome is active but not essential in endotoxin-induced uveitis

(2011) Holly L. Rosenzweig et al.   INFLAMMATION RESEARCH

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

(2009) Juan Pablo de Rivero Vaccari et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

The NALP3/Cryopyrin-Inflammasome Complex is Expressed in LPS-Induced Ocular Inflammation

(2008) José F. González-Benítez et al.   MEDIATORS OF INFLAMMATION