Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating

Ca2+ leak through ryanodine receptor 1 regulates thermogenesis in resting skeletal muscle

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A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke

(2021) Toshiko Yamazawa et al.   Nature Communications

Sex‐specific alterations in whole body energetics and voluntary activity in heterozygous R163C malignant hyperthermia‐susceptible mice

(2020) Jennifer M. Rutkowsky et al.   FASEB JOURNAL

Single-cell temperature mapping with fluorescent thermometer nanosheets

(2020) Kotaro Oyama et al.   JOURNAL OF GENERAL PHYSIOLOGY

Transient Receptor Potential Cation Channels and Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia

(2020) Jose Rafael Lopez et al.   ANESTHESIOLOGY

Investigating dual Ca 2+ modulation of the ryanodine receptor 1 by molecular dynamics simulation

(2020) Wenjun Zheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Overlapping Mechanisms of Exertional Heat Stroke and Malignant Hyperthermia: Evidence vs. Conjecture

(2020) Orlando Laitano et al.   SPORTS MEDICINE

Structural mechanism of two gain-of-function cardiac and skeletal RyR mutations at an equivalent site by cryo-EM

(2020) Kavita A. Iyer et al.   Science Advances

Molecular Modification of Transient Receptor Potential Canonical 6 Channels Modulates Calcium Dyshomeostasis in a Mouse Model Relevant to Malignant Hyperthermia

(2020) Jose Rafael Lopez et al.   ANESTHESIOLOGY

Microscopic heat pulses activate cardiac thin filaments

(2019) Shuya Ishii et al.   JOURNAL OF GENERAL PHYSIOLOGY

An Assessment of Penetrance and Clinical Expression of Malignant Hyperthermia in Individuals Carrying Diagnostic Ryanodine Receptor 1 Gene Mutations

(2019) Carlos A. Ibarra Moreno et al.   ANESTHESIOLOGY

Insights into channel modulation mechanism of RYR1 mutants using Ca2+ imaging and molecular dynamics

(2019) Toshiko Yamazawa et al.   JOURNAL OF GENERAL PHYSIOLOGY

Malignant Hyperthermia in the Post-Genomics Era

(2018) Sheila Riazi et al.   ANESTHESIOLOGY

Pulsed Infrared Releases Ca2+ from the Endoplasmic Reticulum of Cultured Spiral Ganglion Neurons

(2018) John N Barrett et al.   JOURNAL OF NEUROPHYSIOLOGY

Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1

(2018) J.R. Lopez et al.   BRITISH JOURNAL OF ANAESTHESIA

Voltage modulates halothane-triggered Ca2+release in malignant hyperthermia-susceptible muscle

(2017) Alberto Zullo et al.   JOURNAL OF GENERAL PHYSIOLOGY

Investigating the inter-subunit/subdomain interactions and motions relevant to disease mutations in the N-terminal domain of ryanodine receptors by molecular dynamics simulation

(2017) Wenjun Zheng et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ca 2+ -associated triphasic pH changes in mitochondria during brown adipocyte activation

(2017) Yanyan Hou et al.   Molecular Metabolism

Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes

(2017) Rókus Kriszt et al.   Scientific Reports

Malignant hyperthermia-associated mutations in the S2-S3 cytoplasmic loop of type 1 ryanodine receptor calcium channel impair calcium-dependent inactivation

(2016) Angela C. Gomez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Identification of variants of the ryanodine receptor type 1 in patients with exertional heat stroke and positive response to the malignant hyperthermia in vitro contracture test

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Genotype-Phenotype Correlations of Malignant Hyperthermia and Central Core Disease Mutations in the Central Region of the RYR1 Channel

(2016) Takashi Murayama et al.   HUMAN MUTATION

High-frequency sarcomeric auto-oscillations induced by heating in living neonatal cardiomyocytes of the rat

(2015) Seine A. Shintani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Directional Bleb Formation in Spherical Cells under Temperature Gradient

(2015) Kotaro Oyama et al.   BIOPHYSICAL JOURNAL

Exertional Heat Stroke and Susceptibility to Malignant Hyperthermia in an Athlete: Evidence for a Link?

(2015) Mathias Poussel et al.   JOURNAL OF ATHLETIC TRAINING

Nano-imaging of the beating mouse heart in vivo: Importance of sarcomere dynamics, as opposed to sarcomere length per se, in the regulation of cardiac function

(2015) Fuyu Kobirumaki-Shimozawa et al.   JOURNAL OF GENERAL PHYSIOLOGY

Malignant hyperthermia: a review

(2015) Henry Rosenberg et al.   Orphanet Journal of Rare Diseases

Triggering of high-speed neurite outgrowth using an optical microheater

(2015) Kotaro Oyama et al.   Scientific Reports

Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region

(2015) Takashi Murayama et al.   PLoS One

Imaging intraorganellar Ca2+ at subcellular resolution using CEPIA

(2014) Junji Suzuki et al.   Nature Communications

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain

(2014) Kelvin Lau et al.   Nature Communications

Skeletal Muscle Ryanodine Receptor Mutations Associated with Malignant Hyperthermia Showed Enhanced Intensity and Sensitivity to Triggering Drugs when Expressed in Human Embryonic Kidney Cells

(2013) Keisaku Sato et al.   ANESTHESIOLOGY

Disease mutations in the ryanodine receptor N-terminal region couple to a mobile intersubunit interface

(2013) Lynn Kimlicka et al.   Nature Communications

Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics

(2012) Y Kanda   BONE MARROW TRANSPLANTATION

AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation

(2012) Johanna T Lanner et al.   NATURE MEDICINE

Mapping domains and mutations on the skeletal muscle ryanodine receptor channel

(2012) Jean H. Hwang et al.   TRENDS IN MOLECULAR MEDICINE

Microscopic heat pulses induce contraction of cardiomyocytes without calcium transients

(2011) Kotaro Oyama et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of Amino-terminal Half of the S4-S5 Linker in Type 1 Ryanodine Receptor (RyR1) Channel Gating

(2011) Takashi Murayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Studies of RYR1 Mutations in the Skeletal Muscle Ryanodine Receptor Using Human RYR1 Complementary DNA

(2010) Keisaku Sato et al.   ANESTHESIOLOGY

A bicistronic lentiviral vector-based method for differential transsynaptic tracing of neural circuits

(2010) Yohei Ohashi et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The amino-terminal disease hotspot of ryanodine receptors forms a cytoplasmic vestibule

(2010) Ching-Chieh Tung et al.   NATURE

Ryanodine Receptors: Structure, Expression, Molecular Details, and Function in Calcium Release

(2010) J. T. Lanner et al.   Cold Spring Harbor Perspectives in Biology

Highly thermosensitive Ca2+ dynamics in a HeLa cell through IP3 receptors

(2009) Vadim Tseeb et al.   HFSP Journal

The cell boundary theorem: a simple law of the control of cytosolic calcium concentration

(2009) Eduardo Ríos   Journal of Physiological Sciences

Temporal switching and cell-to-cell variability in Ca2+ release activity in mammalian cells

(2009) Naotoshi Nakamura et al.   Molecular Systems Biology

Calcium-Induced Calcium Release in Skeletal Muscle

(2009) Makoto Endo   PHYSIOLOGICAL REVIEWS

A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice

(2009) Z. Andronache et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RyR1 S-Nitrosylation Underlies Environmental Heat Stroke and Sudden Death in Y522S RyR1 Knockin Mice

(2008) William J. Durham et al.   CELL

Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm

(2008) S TREVES et al.   CURRENT OPINION IN PHARMACOLOGY

Reduced Threshold for Luminal Ca2+Activation of RyR1 Underlies a Causal Mechanism of Porcine Malignant Hyperthermia

(2008) Dawei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY