A theory of resistance to multiplexed gene drive demonstrates the significant role of weakly deleterious natural genetic variation

Gene drive escape from resistance depends on mechanism and ecology

(2022) Forest Cook et al.   Evolutionary Applications

Gene drives and population persistence vs elimination: The impact of spatial structure and inbreeding at low density

(2022) P.J. Beaghton et al.   THEORETICAL POPULATION BIOLOGY

Suppression gene drive in continuous space can result in unstable persistence of both drive and wild‐type alleles

(2021) Jackson Champer et al.   MOLECULAR ECOLOGY

Population modification strategies for malaria vector control are uniquely resilient to observed levels of gene drive resistance alleles

(2021) Gregory C. Lanzaro et al.   BIOESSAYS

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape

(2021) Fabian Schmidt et al.   NATURE

Understanding the evolution of multiple drug resistance in structured populations

(2021) David V McLeod et al.   eLife

Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs

(2020) Samuel E. Champer et al.   Science Advances

Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility

(2020) Ace R. North et al.   BMC BIOLOGY

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population

(2020) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleave and Rescue, a novel selfish genetic element and general strategy for gene drive

(2019) Georg Oberhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling the potential of genetic control of malaria mosquitoes at national scale

(2019) Ace R. North et al.   BMC BIOLOGY

Robust estimation of recent effective population size from number of independent origins in soft sweeps

(2019) Bhavin S Khatri et al.   MOLECULAR BIOLOGY AND EVOLUTION

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Vector control with driving Y chromosomes: modelling the evolution of resistance

(2017) Andrea Beaghton et al.   MALARIA JOURNAL

Dodging silver bullets: good CRISPR gene-drive design is critical for eradicating exotic vertebrates

(2017) Thomas A. A. Prowse et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Profiling single-guide RNA specificity reveals a mismatch sensitive core sequence

(2017) Ting Zheng et al.   Scientific Reports

Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies

(2017) Burcu Tepekule et al.   PLoS Computational Biology

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

(2017) Andrew M. Hammond et al.   PLoS Genetics

Evolutionary dynamics of CRISPR gene drives

(2017) Charleston Noble et al.   Science Advances

Overcoming evolved resistance to population-suppressing homing-based gene drives

(2017) John M. Marshall et al.   Scientific Reports

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

Evolution of Resistance Against CRISPR/Cas9 Gene Drive

(2016) Robert L. Unckless et al.   GENETICS

The Population Genetics of Evolutionary Rescue

(2014) H. Allen Orr et al.   PLoS Genetics

Concerning RNA-guided gene drives for the alteration of wild populations

(2014) Kevin M Esvelt et al.   eLife

Estimation of the Spontaneous Mutation Rate per Nucleotide Site in a Drosophila melanogaster Full-Sib Family

(2013) Peter D. Keightley et al.   GENETICS

Evolutionary dynamics of cancer in response to targeted combination therapy

(2013) Ivana Bozic et al.   eLife

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Standing Genetic Variation and the Evolution of Drug Resistance in HIV

(2012) Pleuni Simone Pennings   PLoS Computational Biology

On the Fixation Process of a Beneficial Mutation in a Variable Environment

(2011) Hildegard Uecker et al.   GENETICS

Evidence that Adaptation in Drosophila Is Not Limited by Mutation at Single Sites

(2010) Talia Karasov et al.   PLoS Genetics

Population Extinction and the Genetics of Adaptation

(2008) H. Allen Orr et al.   AMERICAN NATURALIST