Modeling antibiotic treatment in hospitals: A systematic approach shows benefits of combination therapy over cycling, mixing, and mono-drug therapies

Antibiotic Cycling and Antibiotic Mixing: which one best mitigates antibiotic resistance?

(2017) R. E. Beardmore et al.   MOLECULAR BIOLOGY AND EVOLUTION

Evaluation of a Mixing versus a Cycling Strategy of Antibiotic Use in Critically-Ill Medical Patients: Impact on Acquisition of Resistant Microorganisms and Clinical Outcomes

(2016) Nazaret Cobos-Trigueros et al.   PLoS One

Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults

(2015) Douwe F. Postma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imperfect drug penetration leads to spatial monotherapy and rapid evolution of multidrug resistance

(2015) Stefany Moreno-Gamez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic Restriction Might Facilitate the Emergence of Multi-drug Resistance

(2015) Uri Obolski et al.   PLoS Computational Biology

A Population Model Evaluating the Consequences of the Evolution of Double-Resistance and Tradeoffs on the Benefits of Two-Drug Antibiotic Treatments

(2014) Ellsworth M. Campbell et al.   PLoS One

Cycling Empirical Antibiotic Therapy in Hospitals: Meta-Analysis and Models

(2014) Pia Abel zur Wiesch et al.   PLoS Pathogens

β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia

(2014) Nicolas Garin et al.   JAMA Internal Medicine

Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012

(2013) R. P. Dellinger et al.   INTENSIVE CARE MEDICINE

Antibiotic resistance—the need for global solutions

(2013) Ramanan Laxminarayan et al.   LANCET INFECTIOUS DISEASES

Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Importance of Combination Therapy

(2012) M. Tumbarello et al.   CLINICAL INFECTIOUS DISEASES

Combination Therapy for Treatment of Infections with Gram-Negative Bacteria

(2012) P. D. Tamma et al.   CLINICAL MICROBIOLOGY REVIEWS

Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis

(2012) Frank M. Brunkhorst   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A 9-Year retrospective review of antibiotic cycling in a surgical intensive care unit

(2012) Shiva Sarraf-Yazdi et al.   JOURNAL OF SURGICAL RESEARCH

Informed Switching Strongly Decreases the Prevalence of Antibiotic Resistance in Hospital Wards

(2011) Roger D. Kouyos et al.   PLoS Computational Biology

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia*

(2009) Daren K. Heyland et al.   CRITICAL CARE MEDICINE

Combination antibiotic therapy with macrolides improves survival in intubated patients with community-acquired pneumonia

(2009) I. Martin-Loeches et al.   INTENSIVE CARE MEDICINE

Outbreak of Resistant Pseudomonas aeruginosa Infections during a Quarterly Cycling Antibiotic Regimen

(2008) Traci L. Hedrick et al.   Surgical Infections