Xanthotoxin (8‐methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity

Photodynamic therapy fortified with topical oleyl alcohol-based transethosomal 8-methoxypsoralen for ameliorating vitiligo: Optimization and clinical study

(2022) Dina B. Mahmoud et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Potential Anticancer Activity of the Furanocoumarin Derivative Xanthotoxin Isolated from Ammi majus L. Fruits: In Vitro and In Silico Studies

(2022) Marwa Y. Issa et al.   MOLECULES

Ginsenosides in central nervous system diseases: Pharmacological actions, mechanisms, and therapeutics

(2022) Jing Lu et al.   PHYTOTHERAPY RESEARCH

Overcoming drug delivery barriers and challenges in topical therapy of atopic dermatitis: A nanotechnological perspective

(2022) Chetna Hemrajani et al.   BIOMEDICINE & PHARMACOTHERAPY

Evaluation of photocytotoxicity liposomal form of furanocoumarins Sosnowsky's hogweed

(2022) Oleg A. Kulikov et al.   CHEMICO-BIOLOGICAL INTERACTIONS

A multi-faceted comparison of phytochemicals in seven citrus peels and improvement of chemical composition and antioxidant activity by steaming

(2022) Gwang Jin Lee et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Mechanisms of the Procognitive Effects of Xanthotoxin and Umbelliferone on LPS-Induced Amnesia in Mice

(2021) Łukasz Kurach et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological Correction of Cisplatin-Induced Hemostatic Disorders

(2021) M. V. Filonova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Xanthotoxin enhances the anticonvulsant potency of levetiracetam and valproate in the 6‐Hz corneal stimulation model in mice

(2021) Mirosław Zagaja et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Simultaneous Determination of Five Coumarins in Peucedanum Decursivum Radix by UPLC

(2021) Sinan Ma et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Efficacy of bath‐psoralen and ultraviolet A therapy for mycosis fungoides – retrospective analysis of 62 cases

(2021) Yoichi Shintani et al.   JOURNAL OF DERMATOLOGY

The ethnobotany, phytochemistry and biological properties of genus Ferulago – A review

(2021) Natale Badalamenti et al.   JOURNAL OF ETHNOPHARMACOLOGY

Understanding the phytochemistry and molecular insights to the pharmacology of Angelica archangelica L . (garden angelica) and its bioactive components

(2021) Anudeep Kaur et al.   PHYTOTHERAPY RESEARCH

Bilobalide: A review of its pharmacology, pharmacokinetics, toxicity, and safety

(2021) Jing Lu et al.   PHYTOTHERAPY RESEARCH

The Ratio between Lethal and Mutagenic Damages in the DNA of Plasmids and Bacteriophages Induced by 8-Methoxypsoralen Plus UV (λ ≥ 320 nm) Treatment

(2021) V. Yu. Kotova et al.   RUSSIAN JOURNAL OF GENETICS

Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8‐methoxypsoralen concentration and by replacing plasma with saline

(2021) Viola Hähnel et al.   TRANSFUSION

8-Methoxypsoralen has Anti-inflammatory and Antioxidant Roles in Osteoarthritis Through SIRT1/NF-κB Pathway

(2021) Jichao Li et al.   Frontiers in Pharmacology

Preparation of Oral Core–Shell Zein Nanoparticles to Improve the Bioavailability of Glycyrrhizic Acid for the Treatment of Ulcerative Colitis

(2021) Anxin Wu et al.   BIOMACROMOLECULES

Xanthotoxin induced photoactivated toxicity, oxidative stress and cellular apoptosis in Caenorhabditis elegans under ultraviolet A

(2021) Kan Fu et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

“Q-markers targeted screening” strategy for comprehensive qualitative and quantitative analysis in fingerprints of Angelica dahurica with chemometric methods

(2021) Fang-Yuan Gao et al.   Food Chemistry-X

Methoxsalen-induced advanced bull’s eye maculopathy

(2020) Ratnesh Ranjan et al.   EUROPEAN JOURNAL OF OPHTHALMOLOGY

Furanocoumarins in anticancer therapy – For and against

(2020) Joanna Sumorek-Wiadro et al.   FITOTERAPIA

Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation

(2020) Merhan O. Hindam et al.   PHYTOTHERAPY RESEARCH

Potent Inhibitors of Organic Anion Transporters 1 and 3 From Natural Compounds and Their Protective Effect on Aristolochic Acid Nephropathy

(2020) Caiyu Li et al.   TOXICOLOGICAL SCIENCES

Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action

(2020) Muhanad Elhafiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Vascular Protective Effects of Xanthotoxin and Its Action Mechanism in Rat Aorta and Human Vascular Endothelial Cells

(2020) Li-Hua Cao et al.   JOURNAL OF VASCULAR RESEARCH

Xanthotoxin reverses Parkinson’s disease-like symptoms in zebrafish larvae and mice models: a comparative study

(2020) Ewelina Kozioł et al.   Pharmacological Reports

Quality of Life, Anxiety, and Depression in Patients With Early-Stage Mycosis Fungoides and the Effect of Oral Psoralen Plus UV-A (PUVA) Photochemotherapy on it

(2020) Thomas Graier et al.   Frontiers in Medicine

Inhibition of the glutathione biosynthetic pathway increases phytochemical toxicity to Spodoptera litura and Nilaparvata lugens

(2020) Yongjie Cen et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Transcutol® P Containing SLNs for Improving 8-Methoxypsoralen Skin Delivery

(2020) Giulia Pitzanti et al.   Pharmaceutics

Zebrafish and mouse models for anxiety evaluation – A comparative study with xanthotoxin as a model compound

(2020) Monika Maciąg et al.   BRAIN RESEARCH BULLETIN

Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice

(2020) Joanna Kowalczyk et al.   BEHAVIOURAL BRAIN RESEARCH

Evaluation of Low-Dose, Low-Frequency Oral Psoralen–UV-A Treatment With or Without Maintenance on Early-Stage Mycosis Fungoides

(2019) Pablo Vieyra-Garcia et al.   JAMA Dermatology

Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study

(2019) Qing Chen et al.   MOLECULES

In vitro PUVA treatment triggers calreticulin exposition and HMGB1 release by dying T lymphocytes in GVHD: New insights in extracorporeal photopheresis

(2019) Céline Coppard et al.   JOURNAL OF CLINICAL APHERESIS

Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen

(2019) Jun-Yong Wu et al.   International Journal of Nanomedicine

733 Potent immunogenic cell death (ICD) caused by UVA-Activated 8-Methoxypsoralen (8-MOPA)

(2019) K. Tatsuno et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phototoxic risk assessment on benzophenone UV filters: In vitro assessment and a theoretical model

(2019) Lidan Xiong et al.   TOXICOLOGY IN VITRO

Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AαC) in human bladder RT4 cells

(2019) Medjda Bellamri et al.   ARCHIVES OF TOXICOLOGY

New players in phototherapy: photopharmacology and bio-integrated optoelectronics

(2019) Johannes Morstein et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Cross-Linking Approach to Stabilizing Stimuli-Responsive Colloidal Crystals Engineered with DNA

(2019) Seungkyu Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

8‐Methoxypsoralen protects bovine mammary epithelial cells against lipopolysaccharide‐induced inflammatory injury via suppressing JAK/STAT and NF‐κB pathway

(2019) Jiandong Li et al.   MICROBIOLOGY AND IMMUNOLOGY

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

(2019) Renato Bruni et al.   MOLECULES

RNA interference-mediated knockdown of a cytochrome P450 gene enhanced the toxicity of α-cypermethrin in xanthotoxin-fed larvae of Spodoptera exigua (Hübner)

(2019) Muhammad Hafeez et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Copper-induced H2O2 accumulation confers larval tolerance to xanthotoxin by modulating CYP6B50 expression in Spodoptera litura

(2019) Kai Lu et al.   PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY

Role of the CLOCK protein in liver detoxification

(2019) Mengjing Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Tissue distribution study of Angelica dahurica cv. Yubaizhi in rat by ultra–performance liquid chromatography with tandem mass spectrometry

(2019) You-Bo Zhang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Hepatotoxicity by Methoxsalen: The Innocuous Culprit

(2019) Amreet K. Aujla et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Natural product derived privileged scaffolds in drug discovery

(2019) Emma K Davison et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Inhibition of a novel coumarin on an aquatic rhabdovirus by targeting the early stage of viral infection demonstrates potential application in aquaculture

(2019) Lei Liu et al.   ANTIVIRAL RESEARCH

Enhancing the solubility of natural compound xanthotoxin by modulating stability via cocrystallization engineering

(2019) Jin-Yao Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

A new photosafety screening strategy based on in chemico photoreactivity and in vitro skin exposure for dermally-applied chemicals

(2019) Yosuke Iyama et al.   TOXICOLOGY LETTERS

Scopolamine-Induced Memory Impairment Is Alleviated by Xanthotoxin: Role of Acetylcholinesterase and Oxidative Stress Processes

(2018) Krystyna Skalicka-Wozniak et al.   ACS Chemical Neuroscience

8-Methoxypsoralen Plus Ultraviolet A Reduces the Psoriatic Response to Imiquimod in a Murine Model

(2018) N Shirsath et al.   ACTA DERMATO-VENEREOLOGICA

Furocoumarins: A review of biochemical activities, dietary sources and intake, and potential health risks

(2018) Melissa M. Melough et al.   FOOD AND CHEMICAL TOXICOLOGY

Nanoemulsion containing 8-methoxypsoralen for topical treatment of dermatoses: Development, characterization and ex vivo permeation in porcine skin

(2018) Catarina Amorim Oliveira et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo

(2018) Toril Holien et al.   LASERS IN SURGERY AND MEDICINE

Formulation characterization and in vitro drug release of hydrogel-thickened nanoemulsions for topical delivery of 8-methoxypsoralen

(2018) Thaís Nogueira Barradas et al.   Materials Science & Engineering C-Materials for Biological Applications

Assessment of phototoxicity in pigmented Long-Evans rat: sparfloxacin and 8-methoxypsoralen

(2018) Stephen Turnock et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Apheresis buffy coat collection without photoactivation has no effect on apoptosis, cell proliferation, and total viability of mononuclear cells collected using photopheresis systems

(2018) Zbigniew M. Szczepiorkowski et al.   TRANSFUSION

Infusion of lymphocytes treated with 8-methoxypsoralen and ultraviolet A light induces CD19 + IL-10 + regulatory B cells and promotes skin allograft survival

(2018) YuXiang Wei et al.   TRANSPLANTATION PROCEEDINGS

Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole

(2018) Raghava Choudary Palacharla et al.   XENOBIOTICA

The active compounds derived from Psoralea corylifolia for photochemotherapy against psoriasis-like lesions: The relationship between structure and percutaneous absorption

(2018) Ahmed Alalaiwe et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions

(2018) Christophe D. Guillon et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Photochemical and Pharmacokinetic Characterization of Orally Administered Chemicals to Evaluate Phototoxic Risk

(2018) Yosuke Iyama et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Adaptive homeostasis of the vitamin D–vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity

(2018) Guolin Zhao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

An alternative for extracorporeal photopheresis: 8-methoxypsoralen and UVA-treated leucocytes from allogeneic donors improve graft-versus-host disease in mice

(2018) Holger Budde et al.   VOX SANGUINIS

Antiviral effect of compounds derived from Angelica archangelica L. on Herpes simplex virus-1 and Coxsackievirus B3 infections

(2017) Barbara Rajtar et al.   FOOD AND CHEMICAL TOXICOLOGY

Methoxsalen-induced macular toxicity

(2017) Pukhraj Rishi et al.   INDIAN JOURNAL OF OPHTHALMOLOGY

Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages

(2017) Seung-Bin Lee et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhancement of 8-methoxypsoralen topical delivery via nanosized niosomal vesicles: Formulation development, in vitro and in vivo evaluation of skin deposition

(2017) Ahmed Alaa Kassem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Simultaneous assessment of absorption characteristics of coumarins from Angelicae Pubescentis Radix: In vitro transport across Caco-2 cell and in vivo pharmacokinetics in rats after oral administration

(2017) Yan-Fang Yang et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells

(2017) Magdalena Bartnik et al.   JOURNAL OF ETHNOPHARMACOLOGY

Strategies for Avoiding Benzopyrone Hepatotoxicity in Lymphedema Management—The Role of Pharmacogenetics, Metabolic Enzyme Gene Identification, and Patient Selection

(2017) Minhao Hu et al.   Lymphatic Research and Biology

Hypertrophic differentiation of mesenchymal stem cells is suppressed by xanthotoxin via the p38-MAPK/HDAC4 pathway

(2017) Zhen Cao et al.   Molecular Medicine Reports

Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran

(2017) Saeed Tavakoli et al.   NATURAL PRODUCT RESEARCH

A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis

(2017) Viola Hähnel et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Antiproliferative activity of 8-methoxypsoralen on DU145 prostate cancer cells under UVA and blue light

(2017) Giulio Sturaro et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity

(2017) Guolin Zhao et al.   TOXICOLOGY

ABC-transporter blockage mediated by xanthotoxin and bergapten is the major pathway for chemosensitization of multidrug-resistant cancer cells

(2017) Seyed Abbas Mirzaei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

(2017) Ai-Hong Yang et al.   XENOBIOTICA

Strategies for Avoiding Benzopyrone Hepatotoxicity in Lymphedema Management—The Role of Pharmacogenetics, Metabolic Enzyme Gene Identification, and Patient Selection

(2017) Minhao Hu et al.   Lymphatic Research and Biology

The Combination of Immunosuppressive Drugs with 8-Methoxypsoralen and Ultraviolet a Light Modulates the Myeloid-Derived Dendritic Cell Function

(2017) A. Failli et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Gene expression profiling reveals the role of RIG1 like receptor signaling in p53 dependent apoptosis induced by PUVA in keratinocytes

(2016) Shruti Chowdhari et al.   CELLULAR SIGNALLING

Photochemotherapy of Cutaneous Graft-versus-Host Disease May Reduce Concomitant Visceral Disease

(2016) Nicolas Feldreich et al.   DERMATOLOGY

Impact of Pesticide Resistance on Toxicity and Tolerance of Hostplant Phytochemicals inAmyelois Transitella(Lepidoptera: Pyralidae)

(2016) Vikram A. Bagchi et al.   JOURNAL OF INSECT SCIENCE

Cholinesterase, tyrosinase inhibitory and antioxidant potential of randomly selected Umbelliferous plant species and chromatographic profile of Heracleum platytaenium Boiss. and Angelica sylvestris L. var. sylvestris

(2016) Ilkay Orhan et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

In vitro antimicrobial and acetylcholinesterase inhibitory activities of coumarins from Ferulago carduchorum

(2016) Fereshteh Golfakhrabadi et al.   MEDICINAL CHEMISTRY RESEARCH

Enriched environment ameliorates depression-induced cognitive deficits and restores abnormal hippocampal synaptic plasticity

(2016) K. Mahati et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

The classical photoactivated drug 8-methoxypsoralen and related compounds are effective without UV light irradiation against glioma cells

(2016) Diêgo Madureira de Oliveira et al.   NEUROCHEMISTRY INTERNATIONAL

Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

(2016) C. Dou et al.   OSTEOPOROSIS INTERNATIONAL

The anti-metastatic effect of 8-MOP on hepatocellular carcinoma is potentiated by the down-regulation of bHLH transcription factor DEC1

(2016) Jing Xiong et al.   PHARMACOLOGICAL RESEARCH

Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA)

(2016) Guo-Ying Zuo et al.   PHYTOMEDICINE

In vivo modulation of the behavioral effects of nicotine by the coumarins xanthotoxin, bergapten, and umbelliferone

(2016) Barbara Budzynska et al.   PSYCHOPHARMACOLOGY

Root extract of water dropwort, Oenanthe javanica (Blume) DC, induces protein and gene expression of phase I carcinogen-metabolizing enzymes in HepG2 cells

(2016) Jae Kyeom Kim et al.   SpringerPlus

Comparison of Matrix Solid-Phase Dispersion and Liquid—Solid Extraction Methods Followed by Solid-Phase Extraction in the Analysis of Selected Furanocoumarins fromPimpinellaRoots by HPLC—DAD

(2015) A. Oniszczuk et al.   ACTA CHROMATOGRAPHICA

THE EFFECTS OF XANTHOTOXIN ON THE BIOLOGY AND BIOCHEMISTRY OFGalleria mellonellaL. (LEPIDOPTERA: PYRALIDAE)

(2015) Meltem Erdem et al.   ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY

Constituents of PG201 (Layla®), a multi-component phytopharmaceutical, with inhibitory activity on LPS-induced nitric oxide and prostaglandin E2 productions in macrophages

(2015) Hyun Ji Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Erythema action spectrum of topical 8-methoxypsoralen-sensitized skin re-evaluated: implications for routine clinical practice

(2015) D. Al-Ismail et al.   BRITISH JOURNAL OF DERMATOLOGY

8-Methoxypsoralen Induces Intrinsic Apoptosis in HepG2 Cells: Involvement of Reactive Oxygen Species Generation and ERK1/2 Pathway Inhibition

(2015) Huan Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2

(2015) Ai-Hong Yang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Effects of 8-methoxypsoralen on the metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice

(2015) Mingfei Feng et al.   Drug Metabolism and Pharmacokinetics

8-methoxypsoralen plus UVA (PUVA) therapy normalizes signalling of phosphorylated component of mTOR pathway in psoriatic skin of K5.hTGFβ1 transgenic mice

(2015) Nitesh Shirsath et al.   EXPERIMENTAL DERMATOLOGY

Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration

(2015) Nailiang Guo et al.   EXPERIMENTAL LUNG RESEARCH

Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography

(2015) Magdalena Walasek et al.   FOOD CHEMISTRY

Identification and Profile of Furanocoumarins from the Ribbed Celery (Apium Graveolens L Var. Dulce Mill./ Pers.)

(2015) Agnieszka Najda et al.   FOOD SCIENCE AND TECHNOLOGY RESEARCH

Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment

(2015) Bhawna Jain Garg et al.   JOURNAL OF DRUG TARGETING

Transport of Twelve Coumarins from Angelicae Pubescentis Radix across a MDCK-pHaMDR Cell Monolayer—An in Vitro Model for Blood-Brain Barrier Permeability

(2015) Yan-Fang Yang et al.   MOLECULES

Modification of extracorporeal photopheresis technology with porphyrin precursors. Comparison between 8-methoxypsoralen and hexaminolevulinate in killing human T-cell lymphoma cell lines in vitro

(2014) B. Čunderlíková et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A natural phenylpropionate derivative from Mirabilis himalaica inhibits cell proliferation and induces apoptosis in HepG2 cells

(2014) LingHu Lang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Endothelial nitric oxide synthase is regulated by ERK phosphorylation at Ser602

(2014) John C. Salerno et al.   BIOSCIENCE REPORTS

Comparison of various techniques for the extraction and determination of antioxidants in plants

(2014) Petra Bajerová et al.   JOURNAL OF SEPARATION SCIENCE

Isolation, Cytotoxicity Evaluation and HPLC-Quantification of the Chemical Constituents from Prangos pabularia

(2014) Saleem Farooq et al.   PLoS One

Preparative separation of methoxy derivatives of psoralen using supercritical-fluid chromatography

(2014) O. I. Pokrovskii et al.   Russian Journal of Physical Chemistry B

8-Methoxypsoralen is a competitive inhibitor of glutathione S-transferase P1-1

(2014) Diêgo Madureira de Oliveira et al.   Frontiers in Cellular Neuroscience

Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1

(2014) Chunni Zhang et al.   Scientific Reports

Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation

(2013) Yu-ping Zhu et al.   ACTA PHARMACOLOGICA SINICA

New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire

(2013) Saoussen Ben Salem et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

COGNITIVE DEFICITS AND FUNCTIONAL OUTCOMES IN MAJOR DEPRESSIVE DISORDER: DETERMINANTS, SUBSTRATES, AND TREATMENT INTERVENTIONS

(2013) Roger S. McIntyre et al.   DEPRESSION AND ANXIETY

Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3′-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen

(2013) Cheryl E. Ainslie-Waldman et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation

(2013) Maho Sumiyoshi et al.   Journal of Natural Medicines

Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC–MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract

(2013) Yan-xu Chang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor

(2013) S. D. Alsharari et al.   NICOTINE & TOBACCO RESEARCH

Evaluation of antihyperlipidemic and antitumor activities of isolated coumarins fromSalvadora indica

(2013) Deepa Iyer et al.   PHARMACEUTICAL BIOLOGY

UVA and UVB-Induced 8-Methoxypsoralen Photoadducts and a Novel Method for their Detection by Surface-Enhanced Laser Desorption Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF MS)

(2013) Alexandru D. Buhimschi et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Cytochrome P450 CYP1B1 Interacts with 8-Methoxypsoralen (8-MOP) and Influences Psoralen-Ultraviolet A (PUVA) Sensitivity

(2013) Yusuf Y. Deeni et al.   PLoS One

Implication of novel CYP2C9*57 (p.Asn204His) variant in coumarin hypersensitivity

(2013) Risha Nahar et al.   THROMBOSIS RESEARCH

Activation of GILZ gene by photoactivated 8-methoxypsoralen: Potential role of immunoregulatory dendritic cells in extracorporeal photochemotherapy

(2013) Jeffrey S. Futterleib et al.   TRANSFUSION AND APHERESIS SCIENCE

Purification and anticonvulsant activity of xanthotoxin (8-methoxypsoralen)

(2013) Krystyna Skalicka-Woźniak et al.   Open Life Sciences

The endothelium: influencing vascular smooth muscle in many ways

(2012) Chris R. Triggle et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Relationships between chromatin remodeling and DNA damage repair induced by 8-methoxypsoralen and UVA in yeast Saccharomyces cerevisiae

(2012) Lavínia Almeida Cruz et al.   GENETICS AND MOLECULAR BIOLOGY

Extracorporeal Photopheresis (ECP) in Patients with Steroid-dependent Crohnʼs Disease

(2012) Walter Reinisch et al.   INFLAMMATORY BOWEL DISEASES

UVA irradiation following treatment with topical 8-methoxypsoralen improves bleomycin-induced scleroderma in a mouse model, by reducing the collagen content and collagen gene expression levels in the skin

(2012) Shujiro Hayashi et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Epilepsy in the Renaissance: A survey of remedies from 16th and 17th century German herbals

(2012) Michael Adams et al.   JOURNAL OF ETHNOPHARMACOLOGY

Charting, Navigating, and Populating Natural Product Chemical Space for Drug Discovery

(2012) Hugo Lachance et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of new scavengers for hydroxyl radicals and superoxide dismutase by utilising ultraviolet A photoreaction of 8-methoxypsoralen and a variety of mutants of Escherichia coli: Implications on certain diseases of DNA repair deficiency

(2012) Shamim I. Ahmad et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Pressurized Liquid Extraction of Coumarins from Fruits of Heracleum leskowii with Application of Solvents with Different Polarity under Increasing Temperature

(2012) Krystyna Skalicka-Woźniak et al.   MOLECULES

Down regulation of differentiated embryonic chondrocytes 1 (DEC1) is involved in 8-methoxypsoralen-induced apoptosis in HepG2 cells

(2012) Yan Peng et al.   TOXICOLOGY

Effects of Methoxsalen fromPoncirus trifoliataon Acetylcholinesterase and Trimethyltin-Induced Learning and Memory Impairment

(2011) Jae Kyeom KIM et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Multicenter Photopheresis Intervention Trial in Early-Stage Mycosis Fungoides

(2011) Rakhshandra Talpur et al.   Clinical Lymphoma Myeloma & Leukemia

8-Methoxypsoralen plus UVA treatment increases the proportion of CLA+ CD25+ CD4+ T cells in lymph nodes of K5.hTGFβ1 transgenic mice

(2011) Tej Pratap Singh et al.   EXPERIMENTAL DERMATOLOGY

Risk assessment of coumarin using the bench mark dose (BMD) approach: Children in Norway which regularly eat oatmeal porridge with cinnamon may exceed the TDI for coumarin with several folds

(2011) T.Ø. Fotland et al.   FOOD AND CHEMICAL TOXICOLOGY

Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study

(2011) Amir-Houshang Ehsani et al.   PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE

Successful treatment of resistant alopecia areata with a phototoxic dose of ultraviolet A after topical 8-methoxypsoralen application

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