PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation

(2019) Jordan J. S. VerPlank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heart Failure with Preserved Ejection Fraction

(2018) James D. Gladden et al.   Annual Review of Medicine

A Multi-Protein Complex with TRPC, PDE1C, and A2R Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival

(2018) Yishuai Zhang et al.   CIRCULATION

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: A Translational Study in the Dog and Rabbit

(2018) Toru Hashimoto et al.   CIRCULATION

Desmin Phosphorylation Triggers Preamyloid Oligomers Formation and Myocyte Dysfunction in Acquired Heart FailureNovelty and Significance

(2018) Peter P. Rainer et al.   CIRCULATION RESEARCH

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

(2018) Chengjun Hu et al.   JOURNAL OF CLINICAL INVESTIGATION

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

(2017) Jie Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction

(2016) Sanjiv J. Shah et al.   CIRCULATION

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

(2016) Walter E. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assays for the Degradation of Misfolded Proteins in Cells

(2016) Lili Guo et al.   Jove-Journal of Visualized Experiments

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

(2015) Mark J. Ranek et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling

(2015) Natura Myeku et al.   NATURE MEDICINE

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins

(2015) Sudarsanareddy Lokireddy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins

(2014) Sebastian Kötter et al.   JOURNAL OF CELL BIOLOGY

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

(2013) Viswanathan Rajagopalan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The ubiquitin proteasome system in human cardiomyopathies and heart failure

(2013) Sharlene M. Day   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Protein Kinase G Positively Regulates Proteasome-Mediated Degradation of Misfolded Proteins

(2013) Mark J. Ranek et al.   CIRCULATION

Therapeutic potential of PDE modulation in treating heart disease

(2013) Walter Knight et al.   Future Medicinal Chemistry

Enhanced autophagy ameliorates cardiac proteinopathy

(2013) Md. Shenuarin Bhuiyan et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasomal and lysosomal protein degradation and heart disease

(2013) Xuejun Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetically Induced Moderate Inhibition of the Proteasome in Cardiomyocytes Exacerbates Myocardial Ischemia-Reperfusion Injury in Mice

(2012) Zongwen Tian et al.   CIRCULATION RESEARCH

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

(2011) Jie Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteasome functional insufficiency activates the calcineurin–NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

(2010) Mingxin Tang et al.   CARDIOVASCULAR RESEARCH

Myocardial Ischemic Preconditioning Preserves Postischemic Function of the 26S Proteasome Through Diminished Oxidative Damage to 19S Regulatory Particle Subunits

(2010) Andras Divald et al.   CIRCULATION RESEARCH

Doxycycline Attenuates Protein Aggregation in Cardiomyocytes and Improves Survival of a Mouse Model of Cardiac Proteinopathy

(2010) Hanqiao Zheng et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

Cardiomyocyte Expression of a Polyglutamine Preamyloid Oligomer Causes Heart Failure

(2008) J. Scott Pattison et al.   CIRCULATION

PKA rapidly enhances proteasome assembly and activity in in vivo canine hearts

(2008) Mitsutoshi Asai et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY