NLRP3 Inflammasome and Its Central Role in the Cardiovascular Diseases

Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure

(2020) Nikole J. Byrne et al.   Circulation-Heart Failure

Inflammation and NLRP3 Inflammasome Activation Initiated in Response to Pressure Overload by Ca 2+ /Calmodulin-Dependent Protein Kinase II δ Signaling in Cardiomyocytes Are Essential for Adverse Cardiac Remodeling

(2019) Takeshi Suetomi et al.   CIRCULATION

VSIG4 mediates transcriptional inhibition of Nlrp3 and Il-1β in macrophages

(2019) Xiaoyong Huang et al.   Science Advances

Role of NLRP3 Inflammasome in Cardiac Inflammation and Remodeling after Myocardial Infarction

(2019) Masafumi Takahashi   BIOLOGICAL & PHARMACEUTICAL BULLETIN

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

NLRP3 inflammasome in cardioprotective signaling

(2019) Coert J Zuurbier   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes

(2019) Pu Hong et al.   Journal of Neuroinflammation

Drugs to Inhibit the NLRP3 Inflammasome

(2019) Adolfo Gabriele Mauro et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Effects of the TLR4/Myd88/NF-κB Signaling Pathway on NLRP3 Inflammasome in Coronary Microembolization-Induced Myocardial Injury

(2018) Qiang Su et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Anti-Inflammatory Effects of Vardenafil Against Cholestatic Liver Damage in Mice: a Mechanistic Study

(2018) Dina S. El-Agamy et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Metaflammation: Tissue-Specific Alterations of the NLRP3 Inflammasome Platform in Metabolic Syndrome

(2018) Raffaella Mastrocola et al.   CURRENT MEDICINAL CHEMISTRY

Tet2-Mediated Clonal Hematopoiesis Accelerates Heart Failure Through a Mechanism Involving the IL-1β/NLRP3 Inflammasome

(2018) Soichi Sano et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiovascular diseases, NLRP3 inflammasome, and western dietary patterns

(2018) Luis E. Pavillard et al.   PHARMACOLOGICAL RESEARCH

NLRP3: A Novel Mediator in Cardiovascular Disease

(2018) Wenyi Zhou et al.   Journal of Immunology Research

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation

(2018) Hailin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Statin protects the heart against ischemia-reperfusion injury via inhibition of the NLRP3 inflammasome

(2017) Si-yang Yu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

NLRP3 Phosphorylation Is an Essential Priming Event for Inflammasome Activation

(2017) Nan Song et al.   MOLECULAR CELL

The NLRP3 inflammasome in acute myocardial infarction

(2017) Stefano Toldo et al.   Nature Reviews Cardiology

NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx

(2016) Michael A. Katsnelson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The NLRP3/Caspase-1/Interleukin-1β Axis Is Active in Human Lumbar Cartilaginous Endplate Degeneration

(2016) Pan Tang et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS

(2016) Jun Wu et al.   EXPERIMENTAL CELL RESEARCH

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Elevated levels of triglycerides and vldl-cholesterol provoke activation of nlrp1 inflammasome in endothelial cells

(2016) Silvia Bleda et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia–reperfusion in the mouse

(2016) Stefano Toldo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Lipin-2 regulates NLRP3 inflammasome by affecting P2X 7 receptor activation

(2016) Gema Lordén et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The RNA- and TRIM25-Binding Domains of Influenza Virus NS1 Protein Are Essential for Suppression of NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

(2016) Miyu Moriyama et al.   JOURNAL OF VIROLOGY

NLRX1 attenuates apoptosis and inflammatory responses in myocardial ischemia by inhibiting MAVS-dependent NLRP3 inflammasome activation

(2016) Hongyan Li et al.   MOLECULAR IMMUNOLOGY

Does caspase-12 suppress inflammasome activation?

(2016) Lieselotte Vande Walle et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP

(2016) Mausita Karmakar et al.   Nature Communications

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

(2015) Fadila Telarevic Cero et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of autophagy induces IL-1β release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress

(2015) Huanqi Shi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NF-κB Blockade in Hypothalamic Paraventricular Nucleus Inhibits High-Salt-Induced Hypertension Through NLRP3 and Caspase-1

(2015) Jie Qi et al.   Cardiovascular Toxicology

Sodium tanshinone IIA sulfonate ameliorates ischemia-induced myocardial inflammation and lipid accumulation in Beagle dogs through NLRP3 inflammasome

(2015) Qinghua Hu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Formation of the inflammasome during cardiac allograft rejection

(2015) Keyur B. Shah et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

FGF-21 alleviates diabetes-associated vascular complications: Inhibiting NF-κB/NLRP3 inflammasome-mediated inflammation?

(2015) Mi-Hua Liu   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ellagic acid prevents monocrotaline-induced pulmonary artery hypertension via inhibiting NLRP3 inflammasome activation in rats

(2015) Bing Tang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Bisphosphonate Induces Osteonecrosis of the Jaw in Diabetic Mice via NLRP3/Caspase-1-Dependent IL-1β Mechanism

(2015) Qunzhou Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3/Caspase-1 Axis in Adult Neural Stem Cells

(2015) Zheng Fan et al.   MOLECULAR NEUROBIOLOGY

Zinc- and oxidative property-dependent degradation of pro-caspase-1 and NLRP3 by ziram in mouse macrophages

(2015) Masashi Muroi et al.   TOXICOLOGY LETTERS

Caspase-1 activation by NLRP3 inflammasome dampens IL-33-dependent house dust mite-induced allergic lung inflammation

(2015) Fahima Madouri et al.   Journal of Molecular Cell Biology

Apoptosis-Associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 during Macrophage Swelling

(2015) Vincent Compan et al.   JOURNAL OF IMMUNOLOGY

A Tissue-Specific Role for Nlrp3 in Tubular Epithelial Repair after Renal Ischemia/Reperfusion

(2014) Pieter J. Bakker et al.   AMERICAN JOURNAL OF PATHOLOGY

TXNIP mediates NLRP3 inflammasome activation in cardiac microvascular endothelial cells as a novel mechanism in myocardial ischemia/reperfusion injury

(2014) Yi Liu et al.   BASIC RESEARCH IN CARDIOLOGY

Activation of NLRP3 and AIM2 inflammasomes in Kupffer cells in hepatic ischemia/reperfusion

(2014) Hyo-Yeon Kim et al.   FEBS Journal

NLRP3 Inflammasome as a Novel Player in Myocardial Infarction

(2014) Masafumi Takahashi   International Heart Journal

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

(2014) Fei Zheng et al.   MEDIATORS OF INFLAMMATION

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

(2014) Sijun Yang et al.   Redox Biology

A role for NLRP3 inflammasome in acute myocardial ischaemia-reperfusion injury?

(2013) W. M. C. Jong et al.   CARDIOVASCULAR RESEARCH

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Dimethyl sulfoxide inhibits NLRP3 inflammasome activation

(2013) Huijeong Ahn et al.   IMMUNOBIOLOGY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

TLR-induced PAI-2 expression suppresses IL-1  processing via increasing autophagy and NLRP3 degradation

(2013) S.-Y. Chuang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monosodium urate (MSU) crystals increase gout associated coronary heart disease (CHD) risk through the activation of NLRP3 inflammasome

(2012) Jia He et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome

(2012) S. Lacroix-Lamande et al.   JOURNAL OF IMMUNOLOGY

Premature Subclinical Atherosclerosis in Pediatric Inflammatory Bowel Disease

(2012) Marina Aloi et al.   JOURNAL OF PEDIATRICS

Efficacy and safety of the human anti-IL-1beta monoclonal antibody canakinumab in rheumatoid arthritis: results of a 12-week, phase II, dose-finding study

(2011) Rieke Alten et al.   BMC MUSCULOSKELETAL DISORDERS

Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury

(2011) Masanori Kawaguchi et al.   CIRCULATION