Copper-Catalyzed Azide–Alkyne Cycloaddition (CuAAC) by Functionalized NHC-Based Polynuclear Catalysts: Scope and Mechanistic Insights

The Huisgen Reaction: Milestones of the 1,3‐Dipolar Cycloaddition

(2020) Martin Breugst et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A decade of advances in the reaction of nitrogen sources and alkynes for the synthesis of triazoles

(2020) Jose S.S. Neto et al.   COORDINATION CHEMISTRY REVIEWS

Recent Progress of Cu-Catalyzed Azide-Alkyne Cycloaddition Reactions (CuAAC) in Sustainable Solvents: Glycerol, Deep Eutectic Solvents, and Aqueous Media

(2020) Noel Nebra et al.   MOLECULES

Mechanistic study in azide-alkyne cycloaddition (CuAAC) catalyzed by bifunctional trinuclear copper(I) pyrazolate complex: Shift in rate-determining step

(2020) Vladimir A. Larionov et al.   JOURNAL OF CATALYSIS

Cationic Copper Iminophosphorane Complexes as CuAAC Catalysts: A Mechanistic Study

(2020) Bas Venderbosch et al.   ORGANOMETALLICS

Synthetically Diversified Protein Nanopores: Resolving Click Reaction Mechanisms

(2019) Marius M. Haugland et al.   ACS Nano

NHC copper complexes functionalized with sulfoxide and sulfone moieties

(2019) Anna Szadkowska et al.   APPLIED ORGANOMETALLIC CHEMISTRY

The CuAAC: Principles, Homogeneous and Heterogeneous Catalysts, and Novel Developments and Applications

(2019) Steve Neumann et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Catalyst Activation, Chemoselectivity, and Reaction Rate Controlled by the Counter-Ion in the Cu(I)-Catalyzed Cycloaddition between Azide and Terminal or 1-Iodoalkynes

(2018) Ryan Chung et al.   ACS Catalysis

Influence of Alkyne and Azide Substituents on the Choice of the Reaction Mechanism of the Cu+-Catalyzed Addition of Azides to Iodoalkynes

(2018) Pedro J. Silva et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Mechanistic Study in Click Reactions by Using (N-Heterocyclic carbene)Copper(I) Complexes: Anionic Effects

(2018) Yi-Chen Lin et al.   ORGANOMETALLICS

Synthesis, Structural Characterization and Catalytic Activities of Sulfur-Functionalized NHC-Copper(I) Complexes

(2017) Anna Szadkowska et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Dicopper Cu(I)Cu(I) and Cu(I)Cu(II) Complexes in Copper-Catalyzed Azide–Alkyne Cycloaddition

(2017) Micah S. Ziegler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient and straightforward click synthesis of structurally related dendritic triazoles

(2017) M. I. Mangione et al.   RSC Advances

Cuprophilic interactions in highly luminescent dicopper(i)–NHC–picolyl complexes – fast phosphorescence or TADF?

(2016) Jörn Nitsch et al.   CHEMICAL COMMUNICATIONS

On the Mechanism of Copper(I)-Catalyzed Azide-Alkyne Cycloaddition

(2016) Lei Zhu et al.   CHEMICAL RECORD

Metal-catalyzed azide-alkyne “click” reactions: Mechanistic overview and recent trends

(2016) Changlong Wang et al.   COORDINATION CHEMISTRY REVIEWS

Structural Determinants of Alkyne Reactivity in Copper-Catalyzed Azide-Alkyne Cycloadditions

(2016) Xiaoguang Zhang et al.   MOLECULES

A DFT Study on the Binuclear CuAAC Reaction: Mechanism in Light of New Experiments

(2016) Yılmaz Özkılıç et al.   ORGANOMETALLICS

Exploring potential cooperative effects in dicopper(i)-di-mesoionic carbene complexes: applications in click catalysis

(2016) Stephan Hohloch et al.   Inorganic Chemistry Frontiers

Copper(I) Complexes Bearing Carbenes Beyond Classical N-Heterocyclic Carbenes: Synthesis and Catalytic Activity in “Click Chemistry”

(2015) Yannick D. Bidal et al.   ADVANCED SYNTHESIS & CATALYSIS

A Fluxional Copper Acetylide Cluster in CuAAC Catalysis

(2015) Ata Makarem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dinuclear Copper Intermediates in Copper(I)-Catalyzed Azide-Alkyne Cycloaddition Directly Observed by Electrospray Ionization Mass Spectrometry

(2015) Claudio Iacobucci et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper–NHC complexes in catalysis

(2015) Faïma Lazreg et al.   COORDINATION CHEMISTRY REVIEWS

Copper-catalysed azide–alkyne cycloadditions (CuAAC): an update

(2015) Estela Haldón et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Fluorinated Anions Promoted “on Water” Activity of Di- and Tetranuclear Copper(I) Catalysts for Functional Triazole Synthesis

(2015) Sayantani Saha et al.   ORGANOMETALLICS

Structure and spectroscopic properties of the dimeric copper(I) N-heterocyclic carbene complex [Cu2(CNCt-Bu)2](PF6)2

(2015) Korbinian Riener et al.   Acta Crystallographica Section C-Structural Chemistry

Crystal structure refinement withSHELXL

(2015) George M. Sheldrick   Acta Crystallographica Section C-Structural Chemistry

Isolation of bis(copper) key intermediates in Cu-catalyzed azide-alkyne "click reaction"

(2015) L. Jin et al.   Science Advances

Water-soluble NHC-Cu catalysts: applications in click chemistry, bioconjugation and mechanistic analysis

(2014) Heriberto Díaz Velázquez et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Remarkable Stability of Copper(II)–N-Heterocyclic Carbene Complexes Void of an Anionic Tether

(2014) Benjamin R. M. Lake et al.   ORGANOMETALLICS

Rhodium(I)-N-Heterocyclic Carbene Catalyst for Selective Coupling of N-Vinylpyrazoles with Alkynes via C–H Activation

(2014) Ramón Azpíroz et al.   ACS Catalysis

Catalytic and Computational Studies of N-Heterocyclic Carbene or Phosphine-Containing Copper(I) Complexes for the Synthesis of 5-Iodo-1,2,3-Triazoles

(2014) Steven Lal et al.   ACS Catalysis

An Abnormal N-Heterocyclic Carbene-Copper(I) Complex in Click Chemistry

(2013) Samaresh Chandra Sau et al.   ADVANCED SYNTHESIS & CATALYSIS

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

(2013) Regina Berg et al.   Beilstein Journal of Organic Chemistry

Structural Diversity of Copper(I)-N-Heterocyclic Carbene Complexes; Ligand Tuning Facilitates Isolation of the First Structurally Characterised Copper(I)-NHC Containing a Copper(I)-Alkene Interaction

(2013) Benjamin R. M. Lake et al.   CHEMISTRY-A EUROPEAN JOURNAL

Activating Azides and Alkynes for the Click Reaction with [Cu(aNHC)2I] or [Cu(aNHC)2]+(aNHC = Triazole-Derived Abnormal Carbenes): Structural Characterization and Catalytic Properties

(2013) Stephan Hohloch et al.   EUROPEAN JOURNAL OF INORGANIC CHEMISTRY

Copper(I) Heteroleptic Bis(NHC) and Mixed NHC/Phosphine Complexes: Syntheses and Catalytic Activities in the One-Pot Sequential CuAAC Reaction of Aromatic Amines

(2013) Shuai Guo et al.   ORGANOMETALLICS

Direct Evidence of a Dinuclear Copper Intermediate in Cu(I)-Catalyzed Azide-Alkyne Cycloadditions

(2013) B. T. Worrell et al.   SCIENCE

Copper N-heterocyclic carbene complexes in catalysis

(2013) Jonathan D. Egbert et al.   Catalysis Science & Technology

A water soluble CuI–NHC for CuAAC ligation of unprotected peptides under open air conditions

(2012) Christelle Gaulier et al.   CHEMICAL COMMUNICATIONS

WinGXandORTEP for Windows: an update

(2012) Louis J. Farrugia   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Heteroleptic Bis(N-heterocyclic carbene)Copper(I) Complexes: Highly Efficient Systems for the [3+2] Cycloaddition of Azides and Alkynes

(2012) Faïma Lazreg et al.   ORGANOMETALLICS

The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) “click” reaction and its applications. An overview

(2011) Liyuan Liang et al.   COORDINATION CHEMISTRY REVIEWS

The Use of Ligands in Copper-Catalyzed [3+2] Azide-Alkyne Cycloaddition: Clicker than Click Chemistry?

(2011) Silvia Diez-Gonzalez   CURRENT ORGANIC CHEMISTRY

Reusable ammonium salt-tagged NHC–Cu(i) complexes: preparation and catalytic application in the three component click reaction

(2011) Wenlong Wang et al.   GREEN CHEMISTRY

Experimental Investigation on the Mechanism of Chelation-Assisted, Copper(II) Acetate-Accelerated Azide–Alkyne Cycloaddition

(2011) Gui-Chao Kuang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Copper(I) 1,2,3-Triazol-5-ylidene Complexes as Efficient Catalysts for Click Reactions of Azides with Alkynes

(2011) Tatsuhito Nakamura et al.   ORGANIC LETTERS

Well-defined copper(i) complexes for Click azide–alkyne cycloaddition reactions: one Click beyond

(2011) Silvia Díez-González   Catalysis Science & Technology

How to Conceptualize Catalytic Cycles? The Energetic Span Model

(2010) Sebastian Kozuch et al.   ACCOUNTS OF CHEMICAL RESEARCH

Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(i) acetylides

(2010) Jason E. Hein et al.   CHEMICAL SOCIETY REVIEWS

Experimental Evidence for the Involvement of Dinuclear Alkynylcopper(I) Complexes in Alkyne-Azide Chemistry

(2010) Benjamin R. Buckley et al.   CHEMISTRY-A EUROPEAN JOURNAL

Continuous surface charge polarizable continuum models of solvation. I. General formalism

(2010) Giovanni Scalmani et al.   JOURNAL OF CHEMICAL PHYSICS

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Copper(I) thiophenolate in copper N-heterocyclic carbene preparation

(2010) Federico Cisnetti et al.   TETRAHEDRON LETTERS

Direct Synthesis of Iron, Cobalt, Nickel, and Copper Complexes of N-Heterocyclic Carbenes by Using Commercially Available Metal Powders

(2009) Bin Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

N-Heterocyclic Carbenes in Late Transition Metal Catalysis

(2009) Silvia Díez-González et al.   CHEMICAL REVIEWS

Improved Copper(I)-NHC Catalytic Efficiency on Huisgen Reaction by Addition of Aromatic Nitrogen Donors

(2009) Marie-Laure Teyssot et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reversible substrate binding at copper centers in neutral copper(i) carbene complexes derived from bis(3-tert-butylimidazole-2-ylidene)methane

(2009) Igor V. Shishkov et al.   DALTON TRANSACTIONS

[(NHC)2Cu]X Complexes as Efficient Catalysts for Azide-Alkyne Click Chemistry at Low Catalyst Loadings

(2008) Silvia Díez-González et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A [(NHC)CuCl] complex as a latent Click catalyst

(2008) Silvia Díez-González et al.   CHEMICAL COMMUNICATIONS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS