Article
Cell Biology
Yafang Qian, Peng Ding, Jie Xu, Xiaohu Nie, Bin Lu
Summary: The study found that in temozolomide (TMZ)-resistant glioma cells, the expressions of CCL2 and CCR2 were significantly upregulated, and overexpression of CCL2 reduced the antitumor effect of TMZ by enhancing glycolysis.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Food Science & Technology
Toshihide Suzuki, Makoto Shimizu, Yoshio Yamauchi, Ryuichiro Sato
Summary: Exercise increases the secretion of IL-6, and nobiletin promotes the secretion of IL-6 during exercise. Previous studies have shown that nobiletin increases IL-6 levels in C2C12 cells and rat plasma, while this study further explores how nobiletin enhances the secretion of IL-6 and CXCL-1 through the PKA pathway in beta 2-adrenergic receptor signaling.
FOOD SCIENCE & NUTRITION
(2022)
Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Article
Neurosciences
Jiapei Huang, Lan Yi, Xiaoxiao Yang, Qi Zheng, Jun Zhong, Sen Ye, Xican Li, Hui Li, Dongfeng Chen, Caixia Li
Summary: The transplantation of NSCs combined with ethyl stearate can improve the motor behavioral performance of PD rats by promoting NSCs migration and differentiation into dopaminergic neurons through CCL5/CCR5 signaling pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Cell Biology
Chao Ma, Guangxing Liu, Wei Liu, Wei Xu, Hongtu Li, Shuhua Piao, Yang Sui, Wenhua Feng
Summary: The study demonstrates the essential role of CXCL1 in decidual angiogenesis, which is mediated through promoting endothelial cell proliferation and migration, and modulating the expression of VEGF-A. Experimental validation has confirmed the mechanism by which CXCL1 functions in angiogenesis.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Dermatology
Tomoya Watanabe, Yuko Watanabe, Noriko Ikeda, Michiko Aihara, Yukie Yamaguchi
Summary: This retrospective study aimed to identify potential biomarkers for predicting acute respiratory distress syndrome (ARDS) onset in toxic epidermal necrolysis (TEN) patients. The study found that the levels of CCL2, IL-6, and IL-8 were significantly higher in TEN patients with ARDS compared to those without ARDS and healthy controls. Additionally, the levels of these cytokines decreased after systemic treatment. These findings suggest that IL-8 and CCL2 may be involved in the pathogenesis of TEN-induced ARDS and have potential as predictive markers for ARDS onset.
JOURNAL OF DERMATOLOGY
(2023)
Article
Immunology
Yang Li, Shukun Han, Baokang Wu, Chongli Zhong, Yu Shi, Chao Lv, Lei Fu, Yizhou Zhang, Qi Lang, Zhiyun Liang, Yang Yu, Yu Tian
Summary: CXCL11 expression is higher in tumor tissue and has associations with prognosis, immune cell infiltration, tumor mutation burden, and microsatellite instability. Further investigation into CXCL11 may improve cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Sara R. Nass, Yun K. Hahn, Michael Ohene-Nyako, Virginia D. McLane, M. Imad Damaj, Leroy R. Thacker II, Pamela E. Knapp, Kurt F. Hauser
Summary: Opioid use disorder (OUD) and HIV are comorbid epidemics that can increase depression. HIV and the viral protein Tat can directly induce neuronal injury within reward and emotionality brain circuitry, including the prefrontal cortex (PFC). Such damage involves both excitotoxic mechanisms and more indirect pathways through neuroinflammation, both of which can be worsened by opioid co-exposure. Tat and morphine differentially induce depressive-like behaviors associated with increased neuroinflammation, synaptic losses, and immune fatigue within the PFC.
Article
Dermatology
Kenta Nakamura, Atsuko Ashida, Yukiko Kiniwa, Ryuhei Okuyama
Summary: This study found that CCL5 and CXCL12 in blood may serve as biomarkers to predict the therapeutic effect of anti-PD-1 therapy in patients with advanced malignant melanoma. Patients with lower levels of CCL5 and CXCL12 had more TILs and better disease-specific survival rates, indicating these chemokines could be useful predictors for treatment outcomes.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeonhee Lee, Jangwook Lee, Minkyoung Park, Areum Seo, Kyu Hyeon Kim, Seonmi Kim, Minjung Kang, Eunjeong Kang, Kyung Don Yoo, Sunhwa Lee, Dong Ki Kim, Kook-Hwan Oh, Yon Su Kim, Kwon Wook Joo, Seung Hee Yang
Summary: We investigated the levels of chemokine CCL8 in PD effluent and serum, as well as its tissue expression, and found an association with peritoneal fibrosis. We also found that CCL8 levels significantly increased with the duration of PD and were correlated with peritoneal transport parameters. In a mouse model, CCL8 blockade improved peritoneal inflammation and fibrosis.
Article
Biochemistry & Molecular Biology
Song Xue, Hanfei Tang, Gefei Zhao, Chao Fang, Yang Shen, Dong Yan, Ye Yuan, Weiguo Fu, Zhenyu Shi, Xiao Tang, Daqiao Guo
Summary: The study revealed that CCL8 may promote atherosclerosis by inducing endothelial permeability increase. The NOX2/ROS signaling pathway may be the underlying mechanism for this effect. This research contributes to a deeper understanding of the connection between chemokines and atherosclerosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Sven H. Loosen, Tom F. Ulmer, Simon Labuhn, Jan Bednarsch, Sven A. Lang, Patrick H. Alizai, Anne T. Schneider, Mihael Vucur, Ulf P. Neumann, Tom Luedde, Christoph Roderburg
Summary: This study identified circulating levels of CXCL13 as a previously unrecognized marker for predicting outcomes following the resection of BTC, highlighting the potential role of the CXC chemokine family in BTC pathogenesis.
Article
Biotechnology & Applied Microbiology
Longfei Deng, Jie Ren, Benqin Li, Yinggang Wang, Nianfen Jiang, Yi Wang, Hongjuan Cui
Summary: CCL2 is highly expressed in GBM and is associated with prognosis and immunotherapy response. It can serve as an independent prognostic factor for GBM patients and participate in the regulation of chemokine signaling pathway and inflammatory response.
Article
Oncology
Linping Gu, Yaxian Yao, Zhiwei Chen
Summary: The study explored the interaction among CXCL1/2/8 expressions in NSCLC patients. It revealed that high expression of CXCL1 was associated with worse disease-free survival and overall survival, while high expression of CXCL2 was also linked to poorer survival outcomes. High expression of CXCL1 was identified as an independent factor predicting shorter survival time.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Plant Sciences
Chueh-Tan Chen, Chian-Feng Chen, Tung-Yi Lin, Wei-Jyun Hua, Kate Hua, Ching-Yao Tsai, Chung-Hua Hsu
Summary: The study aimed to investigate the anti-mobility activity of the Chinese medical decoction Kuan-Sin-Yin (KSY) on hepatocellular carcinoma (HCC) cells and elucidate its molecular mechanism. The results showed that KSY inhibited the migration and invasion of HCC cells and induced changes in cell morphology. KSY regulated gene networks related to cell migration, invasion, and movement.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Anne Blank, Irina Kremenetskaia, Ruth M. Urbantat, Gueliz Acker, Kati Turkowski, Josefine Radke, Ulf C. Schneider, Peter Vajkoczy, Susan Brandenburg
Summary: The study identified two distinct myeloid cell populations in human glioblastoma, which play a role in tumor escape mechanisms by expressing alternative proangiogenic factors. Limited efficacy of anti-angiogenic therapy may be due to tumor-infiltrating myeloid cells bypassing VEGF-mediated pathways through expression of alternative proangiogenic factors.
JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ruth M. Urbantat, Anne Blank, Irina Kremenetskaia, Peter Vajkoczy, Gueliz Acker, Susan Brandenburg
Summary: The study found that in glioblastoma, the overexpression of VEGF and CXCL2 was associated with decreased patient survival. However, while there were correlations among molecules in the VEGF pathway, no significant relationship was found between CXCR1/2 and CXCL2/IL8. Brain endothelial cells reacted differently to various proangiogenic molecules compared to peripheral endothelial cells, and treatment with a CXCR2 antagonist reduced endothelial cell motility and sprouting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ruth M. Urbantat, Claudius Jelgersma, Susan Brandenburg, Melina Nieminen-Kelha, Irina Kremenetskaia, Julia Zollfrank, Susanne Mueller, Kerstin Rubarth, Arend Koch, Peter Vajkoczy, Gueliz Acker
Summary: Tumor recurrence in GBM is a major challenge, with upregulation of IL8/CXCL2/CXCR2 signaling induced by TMZ. High TAM infiltration predicts poor survival, while more patients express IL8 in recurrent tumors and TMZ therapy maintains CXCL2 expression. Combination therapy shows enhanced anti-tumoral effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Alexander D. Bungert, Ruth M. Urbantat, Claudius Jelgersma, Biniam M. Bekele, Susanne Mueller, Annett Mueller, Matthaeus Felsenstein, Silke Dusatko, Anne Blank, Adnan Ghori, Philipp Boehm-Sturm, Stefan P. Koch, Peter Vajkoczy, Susan Brandenburg
Summary: This study investigates the impact of Ccr2 deficiency on microglia and macrophages, revealing the balance between these two cell populations in glioma tissue and identifying the involvement of the CCR2/CCL2 axis in the immunologic function of microglia and macrophages beyond migration.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Letter
Pediatrics
Ruth M. Urbantat, Charlotte O. Pioch, Niklas Ziegahn, Miriam S. Stegemann, Mirjam Stahl, Marcus A. Mall, Jobst F. Roehmel
PEDIATRIC PULMONOLOGY
(2023)
Review
Oncology
Ruth M. Urbantat, Peter Vajkoczy, Susan Brandenburg
Summary: Chemokine signaling plays a crucial role in glioblastoma, potentially serving as therapeutic targets for new treatment regimens. Further research and clinical studies are needed to explore the efficacy of these novel chemokine-targeting therapies.
Article
Medicine, General & Internal
Ruth M. Urbantat, Valentin Popper, Elisabeth Menschel, Michael Pfeilstocker, Ernst Forjan, Alexander Nader, Catherine R. Sieghart, Felix Keil, Elisabeth Koller
Summary: CPX-351, a promising new agent for patients with treatment-related and secondary acute myeloid leukemia, can cause a severe whole-body rash. While severe side effects are rare, treatment should be carefully monitored at specialized centers.
CLINICAL CASE REPORTS
(2021)