Mitochondria Associated Germinal Structures in Spermatogenesis: piRNA Pathway Regulation and Beyond

Targeted knock-in mice with a human mutation in GRTH/DDX25 reveals the essential role of phosphorylated GRTH in spermatid development during spermatogenesis

(2019) Raghuveer Kavarthapu et al.   HUMAN MOLECULAR GENETICS

Mouse GTSF1 is an essential factor for secondary piRNA biogenesis

(2018) Takuji Yoshimura et al.   EMBO REPORTS

PNLDC1, mouse pre‐piRNA Trimmer, is required for meiotic and post‐meiotic male germ cell development

(2018) Toru Nishimura et al.   EMBO REPORTS

Systematic In-Depth Proteomic Analysis of Mitochondria-Associated Endoplasmic Reticulum Membranes in Mouse and Human Testes

(2018) Xiaoli Wang et al.   PROTEOMICS

piRNA-Guided Genome Defense: From Biogenesis to Silencing

(2018) Benjamin Czech et al.   Annual Review of Genetics

Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis

(2018) Deqiang Ding et al.   NUCLEIC ACIDS RESEARCH

DAZL Regulates Germ Cell Survival through a Network of PolyA-Proximal mRNA Interactions

(2018) Leah L. Zagore et al.   Cell Reports

DAZL is a master translational regulator of murine spermatogenesis

(2018) Haixin Li et al.   National Science Review

PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

(2017) Deqiang Ding et al.   Nature Communications

TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes

(2017) Müge Akpınar et al.   PLoS Genetics

Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice

(2017) Lihong Zhao et al.   Journal of Animal Science and Biotechnology

Cancer: Untethering Mitochondria from the Endoplasmic Reticulum?

(2017) Maria Sol Herrera-Cruz et al.   Frontiers in Oncology

Identification and Functional Analysis of the Pre-piRNA 3′ Trimmer in Silkworms

(2016) Natsuko Izumi et al.   CELL

DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation

(2016) Joao P. Sousa Martins et al.   JOURNAL OF CELL SCIENCE

Argonaute2 Protein in Rat Spermatogenic Cells Is Localized to Nuage Structures and LAMP2-Positive Vesicles Surrounding Chromatoid Bodies

(2016) Yuki Fujii et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

DAZLExpression Explains Origin and Central Formation of Primordial Germ Cells in Chickens

(2016) Hyung Chul Lee et al.   STEM CELLS AND DEVELOPMENT

There's Something Wrong with my MAM; the ER–Mitochondria Axis and Neurodegenerative Diseases

(2016) Sebastien Paillusson et al.   TRENDS IN NEUROSCIENCES

Chromatoid Body Protein TDRD6 Supports Long 3’ UTR Triggered Nonsense Mediated mRNA Decay

(2016) Grigorios Fanourgakis et al.   PLoS Genetics

MIWI and piRNA-mediated cleavage of messenger RNAs in mouse testes

(2015) Peng Zhang et al.   CELL RESEARCH

Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors

(2015) L. L. Wu et al.   DEVELOPMENT

GASZ and mitofusin‐mediated mitochondrial functions are crucial for spermatogenesis

(2015) Jingjing Zhang et al.   EMBO REPORTS

The RNA helicase MOV10L1 binds piRNA precursors to initiate piRNA processing

(2015) Anastassios Vourekas et al.   GENES & DEVELOPMENT

Spata19is critical for sperm mitochondrial function and male fertility

(2015) Yongjie Mi et al.   MOLECULAR REPRODUCTION AND DEVELOPMENT

piRNA-guided slicing specifies transcripts for Zucchini-dependent, phased piRNA biogenesis

(2015) F. Mohn et al.   SCIENCE

MIWI2 and MILI Have Differential Effects on piRNA Biogenesis and DNA Methylation

(2015) Sergei A. Manakov et al.   Cell Reports

PIWI Slicing and RNA Elements in Precursors Instruct Directional Primary piRNA Biogenesis

(2015) David Homolka et al.   Cell Reports

Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice

(2014) J. Castaneda et al.   EMBO JOURNAL

An atlas of chromatoid body components

(2014) O. Meikar et al.   RNA

Correction: GASZ Is Essential for Male Meiosis and Suppression of Retrotransposon Expression in the Male Germline

(2014) Lang Ma et al.   PLoS Genetics

Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline

(2013) Jonathan P Saxe et al.   EMBO JOURNAL

DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells

(2013) Chika Kawahara et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Expression of MAEL in nuage and non-nuage compartments of rat spermatogenic cells and colocalization with DDX4, DDX25 and MIWI

(2013) Miki Takebe et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mitochondrial protein BmPAPI modulates the length of mature piRNAs

(2013) S. Honda et al.   RNA

GASZ promotes germ cell derivation from embryonic stem cells

(2013) Qian Wang et al.   Stem Cell Research

Blockade of Pachytene piRNA Biogenesis Reveals a Novel Requirement for Maintaining Post-Meiotic Germline Genome Integrity

(2012) Ke Zheng et al.   PLoS Genetics

MITOPLD Is a Mitochondrial Protein Essential for Nuage Formation and piRNA Biogenesis in the Mouse Germline

(2011) Toshiaki Watanabe et al.   DEVELOPMENTAL CELL

piRNA-Associated Germline Nuage Formation and Spermatogenesis Require MitoPLD Profusogenic Mitochondrial-Surface Lipid Signaling

(2011) Huiyan Huang et al.   DEVELOPMENTAL CELL

Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition

(2011) J. Chen et al.   GENES & DEVELOPMENT

Expression of DDX25 in nuage components of mammalian spermatogenic cells: immunofluorescence and immunoelectron microscopic study

(2011) Yuko Onohara et al.   HISTOCHEMISTRY AND CELL BIOLOGY

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

(2011) Serena De Fazio et al.   NATURE

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing

(2011) Michael Reuter et al.   NATURE

Deciphering arginine methylation: Tudor tells the tale

(2011) Chen Chen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PIWI-interacting small RNAs: the vanguard of genome defence

(2011) Mikiko C. Siomi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatoid body and small RNAs in male germ cells

(2011) Oliver Meikar et al.   REPRODUCTION

Relevance of gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) in the structural integrity of the chromatoid body during spermatogenesis

(2010) Hisashi Sato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

MVH in piRNA processing and gene silencing of retrotransposons

(2010) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

Localization of mouse vasa homolog protein in chromatoid body and related nuage structures of mammalian spermatogenic cells during spermatogenesis

(2010) Yuko Onohara et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway

(2010) K. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs

(2010) R. J. A. Frost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specialized piRNA Pathways Act in Germline and Somatic Tissues of the Drosophila Ovary

(2009) Colin D. Malone et al.   CELL

Mili Interacts with Tudor Domain-Containing Protein 1 in Regulating Spermatogenesis

(2009) Jianquan Wang et al.   CURRENT BIOLOGY

Tdrd6 Is Required for Spermiogenesis, Chromatoid Body Architecture, and Regulation of miRNA Expression

(2009) Ana Vasileva et al.   CURRENT BIOLOGY

Gtsf1/Cue110, a gene encoding a protein with two copies of a CHHC Zn-finger motif, is involved in spermatogenesis and retrotransposon suppression in murine testes

(2009) Takuji Yoshimura et al.   DEVELOPMENTAL BIOLOGY

Mitochondrial glutathione peroxidase 4 disruption causes male infertility

(2009) Manuela Schneider et al.   FASEB JOURNAL

Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members

(2009) V. V. Vagin et al.   GENES & DEVELOPMENT

Associations between PIWI proteins and TDRD1/MTR-1 are critical for integrated subcellular localization in murine male germ cells

(2009) Kanako Kojima et al.   GENES TO CELLS

Heat shock protein 2 promoter drives cre expression in spermatocytes of transgenic mice

(2009) Amy L. Inselman et al.   GENESIS

Mitochondrial functionality in reproduction: from gonads and gametes to embryos and embryonic stem cells

(2009) J. Ramalho-Santos et al.   HUMAN REPRODUCTION UPDATE

Depletion of Selenoprotein GPx4 in Spermatocytes Causes Male Infertility in Mice

(2009) Hirotaka Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi

(2009) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

(2009) Alexei A. Aravin et al.   PLoS Genetics

Mouse Maelstrom, a Component of Nuage, Is Essential for Spermatogenesis and Transposon Repression in Meiosis

(2008) Sarah F.C. Soper et al.   DEVELOPMENTAL CELL

DNA methylation of retrotransposon genes is regulated by Piwi family members MILI and MIWI2 in murine fetal testes

(2008) S. Kuramochi-Miyagawa et al.   GENES & DEVELOPMENT

MILI, a PIWI-interacting RNA-binding Protein, Is Required for Germ Line Stem Cell Self-renewal and Appears to Positively Regulate Translation

(2008) Yingdee Unhavaithaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A piRNA Pathway Primed by Individual Transposons Is Linked to De Novo DNA Methylation in Mice

(2008) Alexei A. Aravin et al.   MOLECULAR CELL