PI3K drives the de novo synthesis of coenzyme A from vitamin B5

Redesigning therapies for pantothenate kinase–associated neurodegeneration

(2022) Muhammad I. Munshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

(2020) Benjamin D. Hopkins et al.   Nature Reviews Endocrinology

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

(2020) C. Martinez Calejman et al.   Nature Communications

Compartmentalized acyl-CoA metabolism and roles in chromatin regulation

(2020) Sophie Trefely et al.   Molecular Metabolism

Regulation of coenzyme A levels by degradation: the ‘Ins and Outs’

(2020) Philippe Naquet et al.   PROGRESS IN LIPID RESEARCH

Pan-Cancer Analyses Reveal Genomic Features of FOXM1 Overexpression in Cancer

(2019) Carter Barger et al.   Cancers

Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS

(2019) Min Yuan et al.   Nature Protocols

An allosteric mechanism for potent inhibition of human ATP-citrate lyase

(2019) Jia Wei et al.   NATURE

Human pantothenate kinase 4 is a pseudo‐pantothenate kinase

(2019) Jiangwei Yao et al.   PROTEIN SCIENCE

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

CoA‐dependent activation of mitochondrial acyl carrier protein links four neurodegenerative diseases

(2019) Roald A Lambrechts et al.   EMBO Molecular Medicine

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

(2018) Samuel K. McBrayer et al.   CELL

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

(2018) Benjamin D. Hopkins et al.   NATURE

Mouse ER+/PIK3CAH1047R breast cancers caused by exogenous estrogen are heterogeneously dependent on estrogen and undergo BIM-dependent apoptosis with BH3 and PI3K agents

(2018) Elias E. Stratikopoulos et al.   ONCOGENE

A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract

(2018) Min Sun et al.   HUMAN MUTATION

A relative quantitative positive/negative ion switching method for untargeted lipidomics via high resolution LC-MS/MS from any biological source

(2017) Susanne B. Breitkopf et al.   Metabolomics

Glutathione biosynthesis is a metabolic vulnerability in PI(3)K/Akt-driven breast cancer

(2016) Evan C. Lien et al.   NATURE CELL BIOLOGY

A family of metal-dependent phosphatases implicated in metabolite damage-control

(2016) Lili Huang et al.   Nature Chemical Biology

Acetyl Coenzyme A: A Central Metabolite and Second Messenger

(2015) Federico Pietrocola et al.   Cell Metabolism

A High-Throughput Screen Reveals New Small-Molecule Activators and Inhibitors of Pantothenate Kinases

(2015) Lalit Kumar Sharma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Extracellular 4′-phosphopantetheine is a source for intracellular coenzyme A synthesis

(2015) Balaji Srinivasan et al.   Nature Chemical Biology

Coenzyme A biosynthetic machinery in mammalian cells

(2014) David Lopez Martinez et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Physiological roles of the pantothenate kinases

(2014) Lorraine E. Dansie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

E-CRISP: fast CRISPR target site identification

(2014) Florian Heigwer et al.   NATURE METHODS

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation

(2013) Pascal Furet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

(2013) Chudi O. Ndubaku et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

The p110  and p110  isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis

(2012) T. Utermark et al.   GENES & DEVELOPMENT

Discovery and Preclinical Pharmacology of a Selective ATP-Competitive Akt Inhibitor (GDC-0068) for the Treatment of Human Tumors

(2012) James F. Blake et al.   JOURNAL OF MEDICINAL CHEMISTRY

A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue

(2012) Min Yuan et al.   Nature Protocols

Germline Deletion of Pantothenate Kinases 1 and 2 Reveals the Key Roles for CoA in Postnatal Metabolism

(2012) Matthew Garcia et al.   PLoS One

Stable Isotope Labeling by Essential Nutrients in Cell Culture for Preparation of Labeled Coenzyme A and Its Thioesters

(2011) Sankha S. Basu et al.   ANALYTICAL CHEMISTRY

SILEC: a protocol for generating and using isotopically labeled coenzyme A mass spectrometry standards

(2011) Sankha S Basu et al.   Nature Protocols

A mechanism based protein crosslinker for acyl carrier protein dehydratases

(2010) Jordan L. Meier et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

Pantothenate kinase-associated neurodegeneration: insights from a Drosophila model

(2009) Z. Wu et al.   HUMAN MOLECULAR GENETICS

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective, Orally Bioavailable Inhibitor of Class I PI3 Kinase for the Treatment of Cancer†

(2008) Adrian J. Folkes et al.   JOURNAL OF MEDICINAL CHEMISTRY