HelR is a helicase-like protein that protects RNA polymerase from rifamycin antibiotics

The Enzymes of the Rifamycin Antibiotic Resistome

(2021) Matthew D. Surette et al.   ACCOUNTS OF CHEMICAL RESEARCH

Target protection as a key antibiotic resistance mechanism

(2020) Daniel N. Wilson et al.   NATURE REVIEWS MICROBIOLOGY

Molecular basis for RNA polymerase-dependent transcription complex recycling by the helicase-like motor protein HelD

(2020) Timothy P. Newing et al.   Nature Communications

Mycobacterial HelD is a nucleic acids-clearing factor for RNA polymerase

(2020) Tomáš Kouba et al.   Nature Communications

The δ subunit and NTPase HelD institute a two-pronged mechanism for RNA polymerase recycling

(2020) Hao-Hong Pei et al.   Nature Communications

Mycobacterial SigA and SigB Cotranscribe Essential Housekeeping Genes during Exponential Growth

(2019) Kelley Hurst-Hess et al.   mBio

CDD/SPARCLE: the conserved domain database in 2020

(2019) Shennan Lu et al.   NUCLEIC ACIDS RESEARCH

Snakemake—a scalable bioinformatics workflow engine

(2018) Johannes Köster et al.   BIOINFORMATICS

Structural Basis of Transcription Inhibition by Fidaxomicin (Lipiarmycin A3)

(2018) Wei Lin et al.   MOLECULAR CELL

Ribosome protection by antibiotic resistance ATP-binding cassette protein

(2018) Weixin Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks

(2018) Janine N. Copp et al.   BIOCHEMISTRY

Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis

(2018) Hamed Mosaei et al.   MOLECULAR CELL

Structural basis for antibiotic resistance mediated by theBacillus subtilisABCF ATPase VmlR

(2018) Caillan Crowe-McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

InterPro in 2019: improving coverage, classification and access to protein sequence annotations

(2018) Alex L Mitchell et al.   NUCLEIC ACIDS RESEARCH

Rifampicin can induce antibiotic tolerance in mycobacteria via paradoxical changes in rpoB transcription

(2018) Jun-Hao Zhu et al.   Nature Communications

Kinetics of drug–ribosome interactions defines the cidality of macrolide antibiotics

(2017) Maxim S. Svetlov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

(2017) Byoung-Mo Koo et al.   Cell Systems

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Distinguishing between resistance, tolerance and persistence to antibiotic treatment

(2016) Asher Brauner et al.   NATURE REVIEWS MICROBIOLOGY

Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining

(2015) Xiaoyu Tang et al.   ACS Chemical Biology

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rifampin Induces Hydroxyl Radical Formation in Mycobacterium tuberculosis

(2014) Giovanni Piccaro et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Mechanisms of Transcription through Single-Molecule Experiments

(2014) Manchuta Dangkulwanich et al.   CHEMICAL REVIEWS

UvrD facilitates DNA repair by pulling RNA polymerase backwards

(2014) Vitaly Epshtein et al.   NATURE

Fast and sensitive protein alignment using DIAMOND

(2014) Benjamin Buchfink et al.   NATURE METHODS

Characterization of HelD, an interacting partner of RNA polymerase from Bacillus subtilis

(2014) Jana Wiedermannová et al.   NUCLEIC ACIDS RESEARCH

A rifamycin inactivating phosphotransferase family shared by environmental and pathogenic bacteria

(2014) P. Spanogiannopoulos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance

(2014) B. Javid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Mechanism of tetracycline resistance by ribosomal protection protein Tet(O)

(2013) Wen Li et al.   Nature Communications

Characterization of a Rifampin-Inactivating Glycosyltransferase from a Screen of Environmental Actinomycetes

(2012) Peter Spanogiannopoulos et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Snakemake--a scalable bioinformatics workflow engine

(2012) J. Koster et al.   BIOINFORMATICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structural basis for TetM-mediated tetracycline resistance

(2012) A. Donhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

β-Glucuronidase as a Sensitive and Versatile Reporter in Actinomycetes

(2011) Maksym Myronovskyi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Superfamily I helicases as modular components of DNA-processing machines

(2011) Mark S. Dillingham   BIOCHEMICAL SOCIETY TRANSACTIONS

Drug Tolerance in Replicating Mycobacteria Mediated by a Macrophage-Induced Efflux Mechanism

(2011) Kristin N. Adams et al.   CELL

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

Search and clustering orders of magnitude faster than BLAST

(2010) Robert C. Edgar   BIOINFORMATICS

SF1 and SF2 helicases: family matters

(2010) Margaret E Fairman-Williams et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses

(2009) S. Capella-Gutierrez et al.   BIOINFORMATICS

Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes

(2008) Cleo M. Salisbury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr

(2008) J. Baysarowich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA