Design, synthesis and bioactivity of novel naphthalimide-benzotriazole conjugates against A549 cells via targeting BCL2 G-quadruplex and inducing autophagy

Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression

(2020) Li-Wen Shen et al.   Scientific Reports

Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells

(2019) David Muench et al.   PLoS One

Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress

(2019) Aaron M Fleming et al.   NUCLEIC ACIDS RESEARCH

Folding/unfolding kinetics of G-quadruplexes upstream of the P1 promoter of the human BCL-2 oncogene

(2019) Yuanlei Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death

(2019) Avedis Torossian et al.   HAEMATOLOGICA

Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives

(2019) Sveva Pelliccia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel triazole and morpholine substituted bisnaphthalimide: Synthesis, photophysical and G-quadruplex binding properties

(2019) Zhize Ou et al.   JOURNAL OF MOLECULAR STRUCTURE

Autophagy role(s) in response to oncogenes and DNA replication stress

(2019) Riccardo Vanzo et al.   CELL DEATH AND DIFFERENTIATION

Novel Naphthalimide Derivatives as Selective G-Quadruplex DNA Binders

(2018) Ufuk Yildiz et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Small Molecule Driven Stabilization of Promoter G-Quadruplexes and Transcriptional Regulation of c-MYC

(2018) Tania Das et al.   BIOCONJUGATE CHEMISTRY

Targeting the BCL2 Gene Promoter G-Quadruplex with a New Class of Furopyridazinone-Based Molecules

(2018) Jussara Amato et al.   ChemMedChem

5-Bromo-oxoisoaporphine platinum(II) complexes exhibit tumor cell cytotoxcicity via inhibition of telomerase activity and disruption of c-myc G-quadruplex DNA and mitochondrial functions

(2018) Zu-Zhuang Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel Schizocommunin Derivatives as Telomeric G-Quadruplex Ligands That Trigger Telomere Dysfunction and the Deoxyribonucleic Acid (DNA) Damage Response

(2018) Tong Che et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

(2018) Chiara Marchetti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex

(2018) Ming-Hao Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Organometallic Gold(III) Complexes Similar to Tetrahydroisoquinoline Induce ER-Stress-Mediated Apoptosis and Pro-Death Autophagy in A549 Cancer Cells

(2018) Ke-Bin Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing

(2018) Robert Hänsel-Hertsch et al.   Nature Protocols

Cell penetrating thiazole peptides inhibit c-MYC expression via site-specific targeting of c-MYC G-quadruplex

(2018) Debasish Dutta et al.   NUCLEIC ACIDS RESEARCH

3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

(2018) Yan Sun et al.   Theranostics

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Site-specific amino acid substitution in dodecameric peptides determines the stability and unfolding of c-MYC quadruplex promoting apoptosis in cancer cells

(2018) Pallabi Sengupta et al.   NUCLEIC ACIDS RESEARCH

Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex

(2017) Chan Shan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effects of the central potassium ions on the G-quadruplex and stabilizer binding

(2017) Zhiguo Wang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

(2017) Hong Xu et al.   Nature Communications

G-quadruplex DNA targeted metal complexes acting as potential anticancer drugs

(2017) Qian Cao et al.   Inorganic Chemistry Frontiers

Quadruplex nucleic acids as targets for anticancer therapeutics

(2017) Stephen Neidle   Nature Reviews Chemistry

Telomeric G-quadruplex-forming DNA fragments induce TLR9-mediated and LL-37-regulated invasion in breast cancer cells in vitro

(2016) Johanna M. Tuomela et al.   BREAST CANCER RESEARCH AND TREATMENT

Quadruplex Nucleic Acids as Novel Therapeutic Targets

(2016) Stephen Neidle   JOURNAL OF MEDICINAL CHEMISTRY

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

Downregulation of the WT1 gene expression via TMPyP4 stabilization of promoter G-quadruplexes in leukemia cells

(2016) Saeedeh Ghazaey Zidanloo et al.   TUMOR BIOLOGY

Stabilization of G-Quadruplex DNA, Inhibition of Telomerase Activity, and Tumor Cell Apoptosis by Organoplatinum(II) Complexes with Oxoisoaporphine

(2015) Zhen-Feng Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

A basal level of DNA damage and telomere deprotection increases the sensitivity of cancer cells to G-quadruplex interactive compounds

(2015) Erica Salvati et al.   NUCLEIC ACIDS RESEARCH

Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity

(2015) Wen Zhang et al.   Scientific Reports

The Major G-Quadruplex Formed in the Human BCL-2 Proximal Promoter Adopts a Parallel Structure with a 13-nt Loop in K+ Solution

(2014) Prashansa Agrawal et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure-Based Design and Evaluation of Naphthalene Diimide G-Quadruplex Ligands As Telomere Targeting Agents in Pancreatic Cancer Cells

(2013) Marialuisa Micco et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

(2013) Céline Douarre et al.   NUCLEIC ACIDS RESEARCH

Tetrasubstituted naphthalene diimide ligands with selectivity for telomeric G-quadruplexes and cancer cells

(2010) Sonja M. Hampel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Turning off Transcription of thebcl-2Gene by Stabilizing thebcl-2Promoter Quadruplex with Quindoline Derivatives

(2010) Xiao-Dong Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of a Potent G-Quadruplex-Binding Macrocyclic Heptaoxazole

(2009) Masayuki Tera et al.   CHEMBIOCHEM

Selective Recognition of a DNA G-Quadruplex by an Engineered Antibody†

(2008) Himesh Fernando et al.   BIOCHEMISTRY

An Unbiased Evaluation of CK2 Inhibitors by Chemoproteomics

(2008) James S. Duncan et al.   MOLECULAR & CELLULAR PROTEOMICS

The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents

(2008) D. Sun et al.   MOLECULAR CANCER THERAPEUTICS

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY