The genomic landscape of canine diffuse large B-cell lymphoma identifies distinct subtypes with clinical and therapeutic implications

KDM5 inhibition offers a novel therapeutic strategy for the treatment of KMT2D mutant lymphomas

(2021) James Andrew Heward et al.   BLOOD

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

(2021) Burair A. Alsaihati et al.   Nature Communications

Pan-cancer analysis of SETD2 mutation and its association with the efficacy of immunotherapy

(2021) Mingdong Lu et al.   npj Precision Oncology

Comparative Molecular Life History of Spontaneous Canine and Human Gliomas

(2020) Samirkumar B. Amin et al.   CANCER CELL

The repertoire of mutational signatures in human cancer

(2020) Ludmil B. Alexandrov et al.   NATURE

Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma

(2020) Patrizia Mondello et al.   Cancer Discovery

The Genetic and Molecular Basis for Canine Models of Human Leukemia and Lymphoma

(2020) Anne C. Avery   Frontiers in Oncology

A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

(2020) George W. Wright et al.   CANCER CELL

Cancer type-dependent correlations between TP53 mutations and antitumor immunity

(2020) Lin Li et al.   DNA REPAIR

TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate

(2020) Leandro Venturutti et al.   CELL

Phase I Study of Lysine-Specific Demethylase-1 Inhibitor CC-90011 in Patients With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma

(2020) Antoine Hollebecque et al.   CLINICAL CANCER RESEARCH

The prevalence and characterisation of TRAF3 and POT1 mutations in canine B-cell lymphoma

(2020) P.A.D. Smith et al.   VETERINARY JOURNAL

Histone Variant H3.3 Mutations in Defining the Chromatin Function in Mammals

(2020) Matteo Trovato et al.   Cells

The Histone Demethylase UTX/KDM6A in Cancer: Progress and Puzzles

(2019) Wolfgang A. Schulz et al.   INTERNATIONAL JOURNAL OF CANCER

Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma

(2019) Kim Wong et al.   Nature Communications

Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview

(2019) Tyler S. McCann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified

(2019) Maria Antonella Laginestra et al.   MODERN PATHOLOGY

Genetic alterations and their clinical implications in DLBCL

(2019) Yi Miao et al.   Nature Reviews Clinical Oncology

Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia

(2019) Fary Diop et al.   HAEMATOLOGICA

Opportunities and challenges of active immunotherapy in dogs with B-cell lymphoma: a 5-year experience in two veterinary oncology centers

(2019) Laura Marconato et al.   Journal for ImmunoTherapy of Cancer

TRAF3 regulates the oncogenic proteins Pim2 and c-Myc to restrain survival in normal and malignant B cells

(2019) Amy L. Whillock et al.   Scientific Reports

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma.

(2018) Sharadha Sakthikumar et al.   CANCER RESEARCH

Oncogenic Signaling Pathways in The Cancer Genome Atlas

(2018) Francisco Sanchez-Vega et al.   CELL

Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified

(2018) Meng-Meng Ji et al.   HAEMATOLOGICA

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified

(2018) Meng-Meng Ji et al.   HAEMATOLOGICA

Somatic inactivating PTPRJ mutations and dysregulated pathways identified in canine malignant melanoma by integrated comparative genomic analysis

(2018) William P. D. Hendricks et al.   PLoS Genetics

New molecular and therapeutic insights into canine diffuse large B cell lymphoma elucidates the role of the dog as a model for human disease

(2018) Luca Aresu et al.   HAEMATOLOGICA

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis

(2018) Katerina Hatzi et al.   NATURE IMMUNOLOGY

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Minimal residual disease in lymph nodes after achievement of complete remission predicts time to relapse in dogs with large B-cell lymphoma

(2018) Carmit Chalfon et al.   Veterinary and Comparative Oncology

EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas

(2017) Faizaan Mohammad et al.   NATURE MEDICINE

The Genetic Basis of Hepatosplenic T-cell Lymphoma

(2017) Matthew McKinney et al.   Cancer Discovery

signeR: an empirical Bayesian approach to mutational signature discovery

(2016) Rafael A. Rosales et al.   BIOINFORMATICS

A weighted exact test for mutually exclusive mutations in cancer

(2016) Mark D.M. Leiserson et al.   BIOINFORMATICS

SETD2: an epigenetic modifier with tumor suppressor functionality

(2016) Jun Li et al.   Oncotarget

TRAF3 deficiency promotes metabolic reprogramming in B cells

(2016) Nurbek Mambetsariev et al.   Scientific Reports

Manta: rapid detection of structural variants and indels for germline and cancer sequencing applications

(2015) Xiaoyu Chen et al.   BIOINFORMATICS

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

(2015) Ingegerd Elvers et al.   GENOME RESEARCH

Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis

(2015) Jiyuan Zhang et al.   NATURE MEDICINE

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

(2015) Ana Ortega-Molina et al.   NATURE MEDICINE

Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes

(2015) Bart J.G. Broeckx et al.   Scientific Reports

An Oncogenic Role for Alternative NF-κB Signaling in DLBCL Revealed upon Deregulated BCL6 Expression

(2015) Baochun Zhang et al.   Cell Reports

Genetic inactivation of TRAF3 in canine and human B-cell lymphoma

(2014) K. R. Bushell et al.   BLOOD

Molecular Pathways: Deregulation of Histone H3 Lysine 27 Methylation in Cancer--Different Paths, Same Destination

(2014) T. Ezponda et al.   CLINICAL CANCER RESEARCH

DoGSD: the dog and wolf genome SNP database

(2014) Bing Bai et al.   NUCLEIC ACIDS RESEARCH

Minimal residual disease detection by flow cytometry and PARR in lymph node, peripheral blood and bone marrow, following treatment of dogs with diffuse large B-cell lymphoma

(2014) Luca Aresu et al.   VETERINARY JOURNAL

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

(2013) K. L. Richards et al.   CANCER RESEARCH

Randomized, Placebo-Controlled, Double-Blinded Chemoimmunotherapy Clinical Trial in a Pet Dog Model of Diffuse Large B-cell Lymphoma

(2013) Laura Marconato et al.   CLINICAL CANCER RESEARCH

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples

(2013) Kristian Cibulskis et al.   NATURE BIOTECHNOLOGY

POT1 mutations cause telomere dysfunction in chronic lymphocytic leukemia

(2013) Andrew J Ramsay et al.   NATURE GENETICS

Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

(2013) Rami Rahal et al.   NATURE MEDICINE

Genetic heterogeneity of diffuse large B-cell lymphoma

(2013) Jenny Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canine Lymphomas

(2013) V. E. Valli et al.   VETERINARY PATHOLOGY

Strelka: accurate somatic small-variant calling from sequenced tumor–normal sample pairs

(2012) Christopher T. Saunders et al.   BIOINFORMATICS

Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study

(2012) Z. Y. Xu-Monette et al.   BLOOD

Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma

(2012) Claudia Otto et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

The dog as a possible animal model for human non-Hodgkin lymphoma: a review

(2012) Laura Marconato et al.   HEMATOLOGICAL ONCOLOGY

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

Alteration of BIRC3 and multiple other NF- B pathway genes in splenic marginal zone lymphoma

(2011) D. Rossi et al.   BLOOD

Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma

(2011) Ryan D. Morin et al.   NATURE

Analysis of the coding genome of diffuse large B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE GENETICS

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

(2010) K. Wang et al.   NUCLEIC ACIDS RESEARCH

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Response evaluation criteria for peripheral nodal lymphoma in dogs (v1.0)-a veterinary cooperative oncology group (VCOG) consensus document

(2009) D. M. Vail et al.   Veterinary and Comparative Oncology