Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy

Quantitative Measurement of Cytosolic and Nuclear Penetration of Oligonucleotide Therapeutics

(2022) Kirsten Deprey et al.   ACS Chemical Biology

Targeting autophagy in disease: established and new strategies

(2021) Muhammed Kocak et al.   Autophagy

Stapled β-Hairpins Featuring 4-Mercaptoproline

(2021) Jennifer R. Pace et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Encouraging long‐term survival following autophagy inhibition using neoadjuvant hydroxychloroquine and gemcitabine for high‐risk patients with resectable pancreatic carcinoma

(2021) Samer S. AlMasri et al.   Cancer Medicine

The crystal structure of the FAM134B–GABARAP complex provides mechanistic insights into the selective binding of FAM134 to the GABARAP subfamily

(2021) Junfeng Zhao et al.   FEBS Open Bio

The functions of Atg8-family proteins in autophagy and cancer: linked or unrelated?

(2020) Marine Jacquet et al.   Autophagy

Stapled peptide inhibitors of autophagy adapter LC3B

(2020) Robert A. Cerulli et al.   CHEMBIOCHEM

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves anti–PD-1/PD-L1 immunotherapy

(2020) Muhammad Zaeem Noman et al.   Science Advances

Disrupting the LC3 Interaction Region (LIR) Binding of Selective Autophagy Receptors Sensitizes AML Cell Lines to Cytarabine

(2020) Mateusz Putyrski et al.   Frontiers in Cell and Developmental Biology

Super-assembly of ER-phagy receptor Atg40 induces local ER remodeling at contacts with forming autophagosomal membranes

(2020) Keisuke Mochida et al.   Nature Communications

Chloroquine combined with concurrent radiotherapy and temozolomide for newly diagnosed glioblastoma: a phase IB trial

(2020) Inge Compter et al.   Autophagy

A Phase II Study of the Efficacy and Safety of Chloroquine in Combination With Taxanes in the Treatment of Patients With Advanced or Metastatic Anthracycline-refractory Breast Cancer

(2020) Kartik Anand et al.   Clinical Breast Cancer

Decoding three distinct states of the Syntaxin17 SNARE motif in mediating autophagosome–lysosome fusion

(2020) Ying Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy inhibition enhances PD-L1 expression in gastric cancer

(2019) Xiaojuan Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5

(2019) Jessica Huber et al.   Autophagy

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins

(2019) Martina Wirth et al.   Nature Communications

Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors

(2019) Terje Johansen et al.   JOURNAL OF MOLECULAR BIOLOGY

Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties

(2019) Anthony W. Partridge et al.   MOLECULES

Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds

(2019) Zhaoyang Li et al.   NATURE

AUTACs: Cargo-Specific Degraders Using Selective Autophagy

(2019) Daiki Takahashi et al.   MOLECULAR CELL

Hydrogen Bond Surrogate Stabilization of β-Hairpins

(2018) Nicholas Sawyer et al.   ACS Chemical Biology

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins

(2018) Jianchao Li et al.   Nature Chemical Biology

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

(2018) Leila Peraro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

(2017) Leila Peraro et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cisplatin-induced autophagy protects breast cancer cells from apoptosis by regulating yes-associated protein

(2017) Yulin Jiang et al.   ONCOLOGY REPORTS

Role of the mammalian ATG8/LC3 family in autophagy: differential and compensatory roles in the spatiotemporal regulation of autophagy

(2016) You-Kyung Lee et al.   BMB Reports

Atg8 family LC3/GABARAP proteins are crucial for autophagosome–lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation

(2016) Thanh Ngoc Nguyen et al.   JOURNAL OF CELL BIOLOGY

Analysis of Loops that Mediate Protein–Protein Interactions and Translation into Submicromolar Inhibitors

(2016) Timothy R. Siegert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rapid Onset of Retinal Toxicity From High-Dose Hydroxychloroquine Given for Cancer Therapy

(2015) Loh-Shan B. Leung et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

The role for autophagy in cancer

(2015) Eileen White   JOURNAL OF CLINICAL INVESTIGATION

Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

Role of Autophagy in Cisplatin Resistance in Ovarian Cancer Cells

(2014) Juan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis

(2010) Hilla Weidberg et al.   EMBO JOURNAL

Atg8-family interacting motif crucial for selective autophagy

(2010) Nobuo N. Noda et al.   FEBS LETTERS

Phage-encoded combinatorial chemical libraries based on bicyclic peptides

(2009) Christian Heinis et al.   Nature Chemical Biology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Ligand Binding Mode of GABAA Receptor-Associated Protein

(2008) Oliver H. Weiergräber et al.   JOURNAL OF MOLECULAR BIOLOGY