Leaky Gut in IBD: Intestinal Barrier–Gut Microbiota Interaction

A β-N-acetylhexosaminidase Amuc_2109 from Akkermansia muciniphila protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota

(2022) Kaiyue Qian et al.   Food & Function

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

(2021) Naschla Gasaly et al.   Frontiers in Immunology

Exosomal MicroRNA-181a Derived From Mesenchymal Stem Cells Improves Gut Microbiota Composition, Barrier Function, and Inflammatory Status in an Experimental Colitis Model

(2021) Li Gu et al.   Frontiers in Medicine

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

(2020) Abigail Jarret et al.   CELL

Adrenergic Signaling in Muscularis Macrophages Limits Infection-Induced Neuronal Loss

(2020) Fanny Matheis et al.   CELL

Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation

(2020) Sidhartha R. Sinha et al.   Cell Host & Microbe

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

(2020) Mariya A. Borisova et al.   Nutrients

Exosome‐mediated effects and applications in inflammatory bowel disease

(2020) Dickson K. W. Ocansey et al.   BIOLOGICAL REVIEWS

A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8+ T cells in mice

(2020) Lijuan Wang et al.   GUT

Increased Intestinal Permeability is Associated with Later Development of Crohn’s Disease

(2020) Williams Turpin et al.   GASTROENTEROLOGY

Barrier Protection and Recovery Effects of Gut Commensal Bacteria on Differentiated Intestinal Epithelial Cells In Vitro

(2020) Nooshin Mohebali et al.   Nutrients

Macrophages Maintain Epithelium Integrity by Limiting Fungal Product Absorption

(2020) Aleksandra S. Chikina et al.   CELL

An Insight into the Roles of Dietary Tryptophan and its Metabolites in Intestinal Inflammation and Inflammatory Bowel Disease

(2020) Xiaolan Li et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice

(2019) Benthe van der Lugt et al.   Immunity & Ageing

Colonic epithelial cell diversity in health and inflammatory bowel disease

(2019) Kaushal Parikh et al.   NATURE

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

(2019) Julie Schulthess et al.   IMMUNITY

Elucidation of Akkermansia muciniphila Probiotic Traits Driven by Mucin Depletion

(2019) Jongoh Shin et al.   Frontiers in Microbiology

Light-entrained and brain-tuned circadian circuits regulate ILC3s and gut homeostasis

(2019) Cristina Godinho-Silva et al.   NATURE

Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease

(2019) Hua Fan et al.   Turkish Journal of Gastroenterology

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

(2019) Xiaoyuan Bian et al.   Frontiers in Microbiology

Additional Candida albicans administration enhances the severity of dextran sulfate solution induced colitis mouse model through leaky gut-enhanced systemic inflammation and gut-dysbiosis but attenuated by Lactobacillus rhamnosus L34

(2019) Wimonrat Panpetch et al.   Gut Microbes

A Specific Mutation in Muc2 Determines Early Dysbiosis in Colitis-Prone Winnie Mice

(2019) Marina Liso et al.   INFLAMMATORY BOWEL DISEASES

Commensal microbiota drive the functional diversification of colon macrophages

(2019) Byunghyun Kang et al.   Mucosal Immunology

Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense

(2019) Nicole Y. Lai et al.   CELL

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms

(2018) Jamie M Golden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Iron Sequestration in Microbiota Biofilms As A Novel Strategy for Treating Inflammatory Bowel Disease

(2018) Jean-Paul Motta et al.   INFLAMMATORY BOWEL DISEASES

Sodium Butyrate Inhibits Inflammation and Maintains Epithelium Barrier Integrity in a TNBS-induced Inflammatory Bowel Disease Mice Model

(2018) Guangxin Chen et al.   EBioMedicine

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Plant-Derived Exosomal MicroRNAs Shape the Gut Microbiota

(2018) Yun Teng et al.   Cell Host & Microbe

Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial

(2018) Ilkay Yilmaz et al.   Turkish Journal of Gastroenterology

Probiotics Efficacy on Oxidative Stress Values in Inflammatory Bowel Disease: A Randomized Double-Blinded Placebo-Controlled Pilot Study.

(2018) Andrea Ballini et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Understanding and Preventing the Global Increase of Inflammatory Bowel Disease

(2017) Gilaad G. Kaplan et al.   GASTROENTEROLOGY

Partial to complete abrogation of the subepithelial macrophage barrier against the gut microbiota in patients with ulcerative colitis and Crohn's colitis

(2017) Carlos A Rubio et al.   HISTOPATHOLOGY

Microbial-Derived Butyrate Promotes Epithelial Barrier Function through IL-10 Receptor–Dependent Repression of Claudin-2

(2017) Leon Zheng et al.   JOURNAL OF IMMUNOLOGY

Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility

(2017) Xiaolong Ge et al.   Journal of Translational Medicine

Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway

(2017) Hui Yan et al.   PLoS One

Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages

(2016) Ilana Gabanyi et al.   CELL

A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility

(2016) Mahesh S. Desai et al.   CELL

Leaky gut – concept or clinical entity?

(2016) Eamonn M.M. Quigley   CURRENT OPINION IN GASTROENTEROLOGY

Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease

(2016) Floris Imhann et al.   GUT

Increased Enterococcus faecalis infection is associated with clinically active Crohn disease

(2016) Youlian Zhou et al.   MEDICINE

Core 1– and 3–derived O-glycans collectively maintain the colonic mucus barrier and protect against spontaneous colitis in mice

(2016) K Bergstrom et al.   Mucosal Immunology

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

(2016) Sales Ibiza et al.   NATURE

Constitutive aryl hydrocarbon receptor signaling constrains type I interferon–mediated antiviral innate defense

(2016) Taisho Yamada et al.   NATURE IMMUNOLOGY

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cosmcis an X-linked inflammatory bowel disease risk gene that spatially regulates gut microbiota and contributes to sex-specific risk

(2016) Matthew R. Kudelka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16

(2016) Joakim H. Bergström et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The association between the gut microbiota and the inflammatory bowel disease activity: a systematic review and meta-analysis

(2016) Michelle Prosberg et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Fecal Microbiota in Pediatric Inflammatory Bowel Disease and Its Relation to Inflammation

(2015) Kaija-Leena Kolho et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

(2015) Maayan Levy et al.   CELL

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

(2015) Malin E.V. Johansson et al.   Cell Host & Microbe

Cross-talk between type 3 innate lymphoid cells and the gut microbiota in inflammatory bowel disease

(2015) Kristine-Ann G. Buela et al.   CURRENT OPINION IN GASTROENTEROLOGY

Gut commensal microvesicles reproduce parent bacterial signals to host immune and enteric nervous systems

(2015) Khalid Al-Nedawi et al.   FASEB JOURNAL

Annexin A1–containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair

(2015) Giovanna Leoni et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered Fecal Microbiota in Paediatric Inflammatory Bowel Disease

(2015) Johanna Maukonen et al.   Journal of Crohns & Colitis

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2- b ]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes

(2015) Sophia L. Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease

(2015) S C Nalle et al.   Mucosal Immunology

Tuft-cell-derived IL-25 regulates an intestinal ILC2–epithelial response circuit

(2015) Jakob von Moltke et al.   NATURE

Epidemiology and risk factors for IBD

(2015) Ashwin N. Ananthakrishnan   Nature Reviews Gastroenterology & Hepatology

The gut microbiome restores intrinsic and extrinsic nerve function in germ-free mice accompanied by changes in calbindin

(2015) K. A. McVey Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

(2015) Panagiotis S. Kabouridis et al.   NEURON

Exosome-delivered microRNAs modulate the inflammatory response to endotoxin

(2015) Margaret Alexander et al.   Nature Communications

Remodeling of Tight Junctions and Enhancement of Barrier Integrity of the CACO-2 Intestinal Epithelial Cell Layer by Micronutrients

(2015) Mary Carmen Valenzano et al.   PLoS One

Crosstalk between Muscularis Macrophages and Enteric Neurons Regulates Gastrointestinal Motility

(2014) Paul Andrew Muller et al.   CELL

The composition of the gut microbiota shapes the colon mucus barrier

(2014) H. E. Jakobsson et al.   EMBO REPORTS

Characteristics of Fecal and Mucosa-Associated Microbiota in Chinese Patients With Inflammatory Bowel Disease

(2014) Liping Chen et al.   MEDICINE

Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness

(2014) Joseph M. Pickard et al.   NATURE

Mucin-type O-glycans and their roles in intestinal homeostasis

(2013) K. S. B. Bergstrom et al.   GLYCOBIOLOGY

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

(2013) Malin E V Johansson et al.   GUT

Intestinal epithelial cells as mediators of the commensal-host immune crosstalk

(2013) Yoshiyuki Goto et al.   IMMUNOLOGY AND CELL BIOLOGY

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins

(2013) Indrajit Das et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-146b improves intestinal injury in mouse colitis by activating nuclear factor-κB and improving epithelial barrier function

(2013) Toshie Nata et al.   JOURNAL OF GENE MEDICINE

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Bifidobacterium longumNCC3001 inhibits AH neuron excitability

(2013) A. Khoshdel et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Faecalibacterium prausnitzii supernatant improves intestinal barrier function in mice DSS colitis

(2013) Anders H Carlsson et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons

(2013) Yu-Kang Mao et al.   Nature Communications

Perspectives on Mucus Properties and Formation--Lessons from the Biochemical World

(2013) D. Ambort et al.   Cold Spring Harbor Perspectives in Medicine

Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

(2012) Michael Camilleri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Butyrate Enhances Intestinal Epithelial Barrier Function via Up-Regulation of Tight Junction Protein Claudin-1 Transcription

(2012) Hong-Bo Wang et al.   DIGESTIVE DISEASES AND SCIENCES

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

(2012) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases

(2012) Henri Duboc et al.   GUT

Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors

(2012) C C Bain et al.   Mucosal Immunology

Exogenous Stimuli Maintain Intraepithelial Lymphocytes via Aryl Hydrocarbon Receptor Activation

(2011) Ying Li et al.   CELL

Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract

(2011) A. P. Moran et al.   GUT

The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells

(2011) Ju Qiu et al.   IMMUNITY

Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation

(2011) Jessica M. Holmn Larsson et al.   INFLAMMATORY BOWEL DISEASES

Enterotypes of the human gut microbiome

(2011) Manimozhiyan Arumugam et al.   NATURE

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

(2011) S. Vetrano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enteric commensal bacteria potentiate epithelial restitution via reactive oxygen species-mediated inactivation of focal adhesion kinase phosphatases

(2011) P. A. Swanson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Aryl Hydrocarbon Receptor Ligands Control Organogenesis of Intestinal Lymphoid Follicles

(2011) E. A. Kiss et al.   SCIENCE

Alternative Activation of Macrophages: Mechanism and Functions

(2010) Siamon Gordon et al.   IMMUNITY

Oxidative stress-induced disruption of epithelial and endothelial tight junctions

(2008) Radhakrishna Rao   Frontiers in Bioscience-Landmark

Role of Intestinal Mucins in Innate Host Defense Mechanisms against Pathogens

(2008) Poonam Dharmani et al.   Journal of Innate Immunity

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE

Neuropeptides activate human mast cell degranulation and chemokine production

(2007) Marianna Kulka et al.   IMMUNOLOGY