Inhibition of astrocytic DRD2 suppresses CNS inflammation in an animal model of multiple sclerosis

Sarm1-mediated neurodegeneration within the enteric nervous system protects against local inflammation of the colon

(2021) Yue Sun et al.   Protein & Cell

Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation

(2020) Yuqing Wu et al.   MOLECULAR CELL

MAFG-driven astrocytes promote CNS inflammation

(2020) Michael A. Wheeler et al.   NATURE

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

Dopaminergic Therapeutics in Multiple Sclerosis: Focus on Th17-Cell Functions

(2019) Mikhail Melnikov et al.   Journal of Neuroimmune Pharmacology

NG2 glia regulate brain innate immunity via TGF-β2/TGFBR2 axis

(2019) Shu-zhen Zhang et al.   BMC Medicine

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Multiple Sclerosis: Mechanisms and Immunotherapy

(2018) Clare Baecher-Allan et al.   NEURON

Multiple Sclerosis

(2018) Daniel S. Reich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Regulation of Astrocyte Functions in Multiple Sclerosis

(2018) Michael A. Wheeler et al.   Cold Spring Harbor Perspectives in Medicine

Extracellular αB-crystallin modulates the inflammatory responses

(2018) Yong-shun Guo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroinflammation in the central nervous system: Symphony of glial cells

(2018) Qiao‐qiao Yang et al.   GLIA

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Gene Expression Profiling of Multiple Sclerosis Pathology Identifies Early Patterns of Demyelination Surrounding Chronic Active Lesions

(2017) Debbie A. E. Hendrickx et al.   Frontiers in Immunology

The Dopamine Imbalance Hypothesis of Fatigue in Multiple Sclerosis and Other Neurological Disorders

(2015) Ekaterina Dobryakova et al.   Frontiers in Neurology

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

A Novel Analgesic Isolated from a Traditional Chinese Medicine

(2014) Yan Zhang et al.   CURRENT BIOLOGY

Interactions between Neutrophils, Th17 Cells, and Chemokines during the Initiation of Experimental Model of Multiple Sclerosis

(2014) Dagmara Weronika Wojkowska et al.   MEDIATORS OF INFLAMMATION

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Regulation of caspase-3 processing by cIAP2 controls the switch between pro-inflammatory activation and cell death in microglia

(2014) E Kavanagh et al.   Cell Death & Disease

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

Neural Correlates of Cognitive Fatigue: Cortico-Striatal Circuitry and Effort–Reward Imbalance

(2013) Ekaterina Dobryakova et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Epigenome-wide differences in pathology-free regions of multiple sclerosis–affected brains

(2013) Jimmy L Huynh et al.   NATURE NEUROSCIENCE

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2+ glial cells

(2013) Zizhen Kang et al.   NATURE NEUROSCIENCE

Thalamo-striato-cortical determinants to fatigue in multiple sclerosis

(2013) Maria Engström et al.   Brain and Behavior

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Detecting cognitive fatigue in multiple sclerosis: Method matters

(2012) L.A.S. Walker et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

CNS-specific Therapy for Ongoing EAE by Silencing IL-17 Pathway in Astrocytes

(2012) Yaping Yan et al.   MOLECULAR THERAPY

Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

(2012) Wei Shao et al.   NATURE

Caspase signalling controls microglia activation and neurotoxicity

(2011) Miguel A. Burguillos et al.   NATURE

Suppression of EAE and prevention of blood–brain barrier breakdown after vaccination with novel bifunctional peptide inhibitor

(2011) Ahmed H. Badawi et al.   NEUROPHARMACOLOGY

Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice

(2011) L. Cai et al.   NEUROSCIENCE

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Frontal networks play a role in fatigue perception in multiple sclerosis.

(2010) Matteo Pardini et al.   BEHAVIORAL NEUROSCIENCE

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Blood–brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE

(2010) Jami Bennett et al.   JOURNAL OF NEUROIMMUNOLOGY

Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis

(2010) Sergio E. Baranzini et al.   NATURE

Astrocyte expression of D2-like dopamine receptors in the prefrontal cortex

(2010) Mihovil Mladinov et al.   Translational Neuroscience

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice

(2009) Lihua Li et al.   BMC NEUROSCIENCE

Role of dopamine in the physiology of T-cells and dendritic cells

(2009) Rodrigo Pacheco et al.   JOURNAL OF NEUROIMMUNOLOGY

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA