12/15-Lipoxygenase Regulation of Diabetic Cognitive Dysfunction Is Determined by Interfering with Inflammation and Cell Apoptosis

The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review

(2022) Daiene Santos Buglio et al.   JOURNAL OF MEDICINAL FOOD

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage

(2019) Thomas Gaberel et al.   STROKE

Platelet-type 12-lipoxygenase deletion provokes a compensatory 12/15-lipoxygenase increase that exacerbates oxidative stress in islet β-cells

(2019) Abass M. Conteh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

(2018) H. Karatas et al.   BRAIN RESEARCH

Activation of the 12/15 lipoxygenase pathway accompanies metabolic decline in db/db pre-diabetic mice

(2018) Anca D. Dobrian et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Dendrimeric Poly(Epsilon-Lysine) Delivery Systems for the Enhanced Permeability of Flurbiprofen across the Blood-Brain Barrier in Alzheimer’s Disease

(2018) Shafq Al-azzawi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Linking senile dementia to type 2 diabetes: role of oxidative stress markers, C-reactive protein and tumor necrosis factor-α

(2017) Merhan Mamdouh Ragy et al.   NEUROLOGICAL RESEARCH

Neuroprotection of taurine through inhibition of 12/15 lipoxygenase pathway in cerebral ischemia of rats

(2017) Zhe Zhang et al.   NEUROLOGICAL RESEARCH

Formononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP

(2017) Lizhi Chen et al.   NEUROSCIENCE LETTERS

Neuroprotective Effects of Aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by β-Amyloid in Rats

(2017) Nutchareeporn Nillert et al.   Nutrients

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

(2016) N. N. Rumzhum et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Reversal of diabetes-induced behavioral and neurochemical deficits by cinnamaldehyde

(2016) Akshay Jawale et al.   PHYTOMEDICINE

Diabetes mellitus and the central nervous system

(2016) E. V. Surkova   TERAPEVTICHESKII ARKHIV

Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia

(2016) Kazim Yigitkanli et al.   Translational Stroke Research

5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease

(2015) Olof Rådmark et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Chemical Molecule B355252 is Neuroprotective in an In Vitro Model of Parkinson’s Disease

(2015) Nailya S. Gliyazova et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Central Insulin Administration Improves Odor-Cued Reactivation of Spatial Memory in Young Men

(2015) Yvonne F. Brünner et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Inflammation and Oxidative Stress: The Molecular Connectivity between Insulin Resistance, Obesity, and Alzheimer’s Disease

(2015) Giuseppe Verdile et al.   MEDIATORS OF INFLAMMATION

Inflammation is genetically implicated in Parkinson’s disease

(2015) N. Dzamko et al.   NEUROSCIENCE

The 12/15-lipoxygenase as an emerging therapeutic target for Alzheimer's disease

(2015) Yash B. Joshi et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A novel role for 12/15-lipoxygenase in regulating autophagy

(2015) Alwena H. Morgan et al.   Redox Biology

Arachidonate 12/15-Lipoxygenase–Induced Inflammation and Oxidative Stress Are Involved in the Development of Diabetic Cardiomyopathy

(2014) Hirofumi Suzuki et al.   DIABETES

The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing

(2013) L. Luu et al.   DIABETOLOGIA

Molecular links between Alzheimer’s disease and diabetes mellitus

(2013) Y. Yang et al.   NEUROSCIENCE

Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration

(2012) Ki Sung Kang et al.   BRAIN RESEARCH

Synergistic Interactions between Repeats in Tau Protein and Aβ Amyloids May Be Responsible for Accelerated Aggregation via Polymorphic States

(2011) Yifat Miller et al.   BIOCHEMISTRY

Diabetes as a chronic metabolic stressor: Causes, consequences and clinical complications

(2011) Lawrence P. Reagan   EXPERIMENTAL NEUROLOGY

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

(2011) Xiao-dong Pan et al.   Molecular Neurodegeneration

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Different Roles of 12/15-Lipoxygenase in Diabetic Large and Small Fiber Peripheral and Autonomic Neuropathies

(2010) Irina G. Obrosova et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroprotection of early and short-time applying atorvastatin in the acute phase of cerebral ischemia: Down-regulated 12/15-LOX, p38MAPK and cPLA2 expression, ameliorated BBB permeability

(2010) Lili Cui et al.   BRAIN RESEARCH

Increased Nuclear Apoptosis-Inducing Factor after Transient Focal Ischemia: A 12/15-Lipoxygenase-dependent Organelle Damage Pathway

(2010) Stefanie Pallast et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Loss of  7 Nicotinic Receptors Enhances  -Amyloid Oligomer Accumulation, Exacerbating Early-Stage Cognitive Decline and Septohippocampal Pathology in a Mouse Model of Alzheimer's Disease

(2010) C. M. Hernandez et al.   JOURNAL OF NEUROSCIENCE

Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis

(2010) A Young Choi et al.   NEUROCHEMISTRY INTERNATIONAL

Functional and pathological roles of the 12- and 15-lipoxygenases

(2010) Anca D. Dobrian et al.   PROGRESS IN LIPID RESEARCH

Role of the p38 Mitogen-Activated Protein Kinase/Cytosolic Phospholipase A2 Signaling Pathway in Blood—Brain Barrier Disruption after Focal Cerebral Ischemia and Reperfusion

(2008) Chikako Nito et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HT22 hippocampal neuronal cell line possesses functional cholinergic properties

(2008) Jun Liu et al.   LIFE SCIENCES