Ca2+/Calmodulin-Dependent Protein Kinase II Regulation by Inhibitor of Receptor Interacting Protein Kinase 3 Alleviates Necroptosis in Glycation End Products-Induced Cardiomyocytes Injury

Stabilizing cardiac ryanodine receptor prevents the development of cardiac dysfunction and lethal arrhythmia in Ca2+/calmodulin-dependent protein kinase IIδc transgenic mice

(2020) Yoko Sufu-Shimizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitors Targeting RIPK1/RIPK3: Old and New Drugs

(2020) Sofie Martens et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

(2020) Huipeng Jiao et al.   NATURE

The role of RIPK3‐regulated cell death pathways and necroptosis in the pathogenesis of cardiac ischaemia‐reperfusion injury

(2020) Luo Ying et al.   Acta Physiologica

Advanced glycation end products in diabetes, cancer and phytochemical therapy

(2020) Begum Dariya et al.   DRUG DISCOVERY TODAY

Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias

(2020) Steffen Pabel et al.   EUROPACE

Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

(2020) Elizabeth D. Luczak et al.   Nature Communications

Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract

(2020) Timme van der Lugt et al.   Nutrients

Necroptosis in Intestinal Inflammation and Cancer: New Concepts and Therapeutic Perspectives

(2020) Anna Negroni et al.   Biomolecules

The Development of Maillard Reaction, and Advanced Glycation End Product (AGE)-Receptor for AGE (RAGE) Signaling Inhibitors as Novel Therapeutic Strategies for Patients with AGE-Related Diseases

(2020) Chieh-Yu Shen et al.   MOLECULES

Chronic Calmodulin-Kinase II Activation Drives Disease Progression in Mutation-Specific Hypertrophic Cardiomyopathy

(2019) Sarah J. Lehman et al.   CIRCULATION

Diabetic cardiomyopathy- A comprehensive updated review

(2019) Ghulam Murtaza et al.   PROGRESS IN CARDIOVASCULAR DISEASES

HIMF (Hypoxia-Induced Mitogenic Factor)-IL (Interleukin)-6 Signaling Mediates Cardiomyocyte-Fibroblast Crosstalk to Promote Cardiac Hypertrophy and Fibrosis

(2019) Santosh Kumar et al.   HYPERTENSION

Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy

(2019) Isabella Evangelista et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Diabetic Cardiomyopathy

(2019) Stefania Paolillo et al.   Heart Failure Clinics

Necroptosis in the Pathophysiology of Disease

(2019) Mitri K. Khoury et al.   AMERICAN JOURNAL OF PATHOLOGY

Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes

(2019) Ping Yang et al.   Oxidative Medicine and Cellular Longevity

Activation of CaMKIIδA promotes Ca2+ leak from the sarcoplasmic reticulum in cardiomyocytes of chronic heart failure rats

(2018) Le Gui et al.   ACTA PHARMACOLOGICA SINICA

Physiological and unappreciated roles of CaMKII in the heart

(2018) Jan Beckendorf et al.   BASIC RESEARCH IN CARDIOLOGY

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Diabetic Cardiomyopathy

(2018) Guanghong Jia et al.   CIRCULATION RESEARCH

Necroptosis in development and diseases

(2018) Bing Shan et al.   GENES & DEVELOPMENT

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

Ablation of phospholamban rescues reperfusion arrhythmias but exacerbates myocardium infarction in hearts with Ca2+/calmodulin kinase II constitutive phosphorylation of ryanodine receptors

(2018) Carlos A Valverde et al.   CARDIOVASCULAR RESEARCH

Implications of advanced oxidation protein products (AOPPs), advanced glycation end products (AGEs) and other biomarkers in the development of cardiovascular diseases

(2018) Mahmood Rasool et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Antagonism of receptor interacting protein 1 using necrostatin-1 in oxidized LDL- induced endothelial injury

(2018) Songtao An et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective

(2017) Salvatore Bongarzone et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases

(2017) Philip A. Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

(2017) Marilen Federico et al.   JOURNAL OF PHYSIOLOGY-LONDON

CaMKII as a target for arrhythmia suppression

(2017) Julian Mustroph et al.   PHARMACOLOGY & THERAPEUTICS

Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca 2+ /Calmodulin‐Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development

(2017) Bandana Chakravarti et al.   Journal of the American Heart Association

Hypoxia-inducible factor-1 alpha is involved in RIP-induced necroptosis caused by in vitro and in vivo ischemic brain injury

(2017) Xiao-Sa Yang et al.   Scientific Reports

Oral AGE restriction ameliorates insulin resistance in obese individuals with the metabolic syndrome: a randomised controlled trial

(2016) Helen Vlassara et al.   DIABETOLOGIA

Low advanced glycation end product diet improves the lipid and inflammatory profiles of prediabetic subjects

(2016) Antonino Di Pino et al.   Journal of Clinical Lipidology

CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress–induced myocardial necroptosis

(2016) Ting Zhang et al.   NATURE MEDICINE

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

The ins and outs of selective kinase inhibitor development

(2015) Susanne Müller et al.   Nature Chemical Biology

RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

(2014) Mark Luedde et al.   CARDIOVASCULAR RESEARCH

RIP kinases: key decision makers in cell death and innate immunity

(2014) F Humphries et al.   CELL DEATH AND DIFFERENTIATION

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

CaMKIIdelta subtypes: localization and function

(2014) Charles B. B. Gray et al.   Frontiers in Pharmacology

Restriction of Advanced Glycation End Products Improves Insulin Resistance in Human Type 2 Diabetes: Potential role of AGER1 and SIRT1

(2011) J. Uribarri et al.   DIABETES CARE

Cardioprotection by CaMKII-δB Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 70

(2009) Wei Peng et al.   CIRCULATION RESEARCH

Critical Role of Nuclear Calcium/Calmodulin-dependent Protein Kinase IIδB in Cardiomyocyte Survival in Cardiomyopathy

(2009) Gillian H. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY