Co-Crystal Structure-Guided Optimization of Dual-Functional Small Molecules for Improving the Peroxygenase Activity of Cytochrome P450BM3

Enantioselective Synthesis of α-Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with Acceptor-Acceptor Carbene Donors

(2022) Donggeon Nam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Different Geometric Requirements for Cytochrome P450-Catalyzed Aliphatic Versus Aromatic Hydroxylation Results in Chemoselective Oxidation

(2022) Tom Coleman et al.   ACS Catalysis

A Chemoenzymatic Strategy for the Synthesis of Steroid Drugs Enabled by P450 Monooxygenase-Mediated Steroidal Core Modification

(2022) Yaqin Peng et al.   ACS Catalysis

Biocatalytic One-Carbon Ring Expansion of Aziridines to Azetidines via a Highly Enantioselective [1,2]-Stevens Rearrangement

(2022) David C. Miller et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Unique P450 Peroxygenase System Facilitated by a Dual-Functional Small Molecule: Concept, Application, and Perspective

(2022) Siyu Di et al.   Antioxidants

Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- and β-Hydroxy-γ4-amino Acids

(2021) Emel Adaligil et al.   ACS Chemical Biology

Unexpected Reactions of α,β‐Unsaturated Fatty Acids Provide Insight into the Mechanisms of CYP152 Peroxygenases

(2021) Yuanyuan Jiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Suite of Activity-Based Probes To Dissect the KLK Activome in Drug-Resistant Prostate Cancer

(2021) Scott Lovell et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Enantiopure Unnatural Amino Acids by Metallaphotoredox Catalysis

(2021) Tomer M. Faraggi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

H-Bonding Networks Dictate the Molecular Mechanism of H2O2 Activation by P450

(2021) Xuan Zhang et al.   ACS Catalysis

Enzymatic Regio- and Enantioselective C–H Oxyfunctionalization of Fatty Acids

(2021) Hao Chen et al.   ACS Catalysis

Engineering P450 TamI as an Iterative Biocatalyst for Selective Late-Stage C–H Functionalization and Epoxidation of Tirandamycin Antibiotics

(2021) Rosa V. Espinoza et al.   ACS Catalysis

Switching an Artificial P450 Peroxygenase into Peroxidase via Mechanism-Guided Protein Engineering

(2021) Nana Ma et al.   ACS Catalysis

Accessing Chemo- and Regioselective Benzylic and Aromatic Oxidations by Protein Engineering of an Unspecific Peroxygenase

(2021) Anja Knorrscheidt et al.   ACS Catalysis

An Overview of Cytochrome P450 Immobilization Strategies for Drug Metabolism Studies, Biosensing, and Biocatalytic Applications: Challenges and Opportunities

(2021) Donya Valikhani et al.   ACS Catalysis

Inspiration from Nature: Influence of Engineered Ligand Scaffolds and Auxiliary Factors on the Reactivity of Biomimetic Oxidants

(2021) Gourab Mukherjee et al.   ACS Catalysis

Enzymatic Hydroxylations of sp3-Carbons

(2021) Judith Münch et al.   ACS Catalysis

A Chiral-Pool-Based Strategy to Access trans-syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-polyveoline and the Chrodrimanins

(2021) Fuzhuo Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Investigation of Isonitrile Formation Catalyzed by the Nonheme Iron/α-KG-Dependent Decarboxylase (ScoE)

(2020) Hong Li et al.   ACS Catalysis

A 2‐Tyr‐1‐Carboxylate Mononuclear Iron Center is the Active Site of Dimethylformamidase

(2020) Chetan Kumar Arya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism-Guided Design and Discovery of Efficient Cytochrome P450-Derived C–H Amination Biocatalysts

(2020) Viktoria Steck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Systematic Evolution of Decoy Molecules for the Highly Efficient Hydroxylation of Benzene and Small Alkanes Catalyzed by Wild-Type Cytochrome P450BM3

(2020) Kai Yonemura et al.   ACS Catalysis

Current state and future perspectives of engineered and artificial peroxygenases for the oxyfunctionalization of organic molecules

(2020) Marie-Cathérine Sigmund et al.   Nature Catalysis

Directed Evolution of a Hydroxylase into a Decarboxylase for Synthesis of 1-Alkenes from Fatty Acids

(2020) Shuaibo Wang et al.   ACS Catalysis

Exploiting Designed Oxidase-Peroxygenase Mutual Benefit System for Asymmetric Cascade Reactions

(2019) Da Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strategies for Substrate‐Regulated P450 Catalysis: From Substrate Engineering to Co‐catalysis

(2019) Jiakun Xu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Peroxide-Driven Hydroxylation of Small Alkanes Catalyzed by an Artificial P450BM3 Peroxygenase System

(2019) Jie Chen et al.   ACS Catalysis

P450BM3-Catalyzed Oxidations Employing Dual Functional Small Molecules

(2019) Willot et al.   Catalysts

ADMET Evaluation in Drug Discovery. 19. Reliable Prediction of Human Cytochrome P450 Inhibition Using Artificial Intelligence Approaches

(2019) Zhenxing Wu et al.   Journal of Chemical Information and Modeling

An enzymatic platform for the asymmetric amination of primary, secondary and tertiary C(sp3)–H bonds

(2019) Yang Yang et al.   Nature Chemistry

Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives

(2018) Masayuki Karasawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecule

(2018) Zhifeng Chen et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

Mechanistic Studies of Fatty Acid Activation by CYP152 Peroxygenases Reveal Unexpected Desaturase Activity

(2018) Mathias Pickl et al.   ACS Catalysis

Mechanisms of Cytochrome P450-Catalyzed Oxidations

(2018) F. Peter Guengerich   ACS Catalysis

Prospects for Applying Synthetic Biology to Toxicology: Future Opportunities and Current Limitations for the Repurposing of Cytochrome P450 Systems

(2016) James B. Y. H. Behrendorff et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Ynamides as Racemization-Free Coupling Reagents for Amide and Peptide Synthesis

(2016) Long Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Peroxygenase reactions catalyzed by cytochromes P450

(2014) Osami Shoji et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Activation of Wild-Type Cytochrome P450BM3 by the Next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence

(2014) Zhiqi Cong et al.   ACS Catalysis

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS