Strategies for Substrate‐Regulated P450 Catalysis: From Substrate Engineering to Co‐catalysis

Whole-Cell Biotransformation of Benzene to Phenol Catalysed by Intracellular Cytochrome P450BM3 Activated by External Additives

(2018) Masayuki Karasawa et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Dual-Functional Small Molecules for Generating an Efficient Cytochrome P450BM3 Peroxygenase

(2018) Nana Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cytochrome P450 diversity in the tree of life

(2018) David R. Nelson   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Chemoenzymatic Route to Oxyfunctionalized Cembranoids Facilitated by Substrate and Protein Engineering

(2018) Priska Le-Huu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent developments in the application of P450 based biocatalysts

(2018) Yifeng Wei et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Design of artificial enzymes by supramolecular strategies

(2018) Tingting Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Stereoselective hydroxylation of isophorone by variants of the cytochromes P450 CYP102A1 and CYP101A1

(2018) Shaghayegh Dezvarei et al.   ENZYME AND MICROBIAL TECHNOLOGY

Efficient hydroxylation of cycloalkanes by co-addition of decoy molecules to variants of the cytochrome P450 CYP102A1

(2018) Shaghayegh Dezvarei et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

The relationships between cytochromes P450 and H 2 O 2 : Production, reaction, and inhibition

(2018) Matthew E. Albertolle et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Selective hydroxylation of naphthalene using the H2O2-dependent engineered P450BM3 driven by dual-functional small molecule

(2018) Zhifeng Chen et al.   JOURNAL OF PORPHYRINS AND PHTHALOCYANINES

A Rationally Designed Myoglobin Exhibits a Catalytic Dehalogenation Efficiency More than 1000-Fold That of a Native Dehaloperoxidase

(2018) Lu−Lu Yin et al.   ACS Catalysis

Green and efficient biosynthesis of indigo from indole by engineered myoglobins

(2018) Can Liu et al.   RSC Advances

Enzymatic Late‐Stage Oxidation of Lead Compounds with Solubilizing Biomimetic Docking/Protecting groups

(2018) Clare Vickers et al.   CHEMISTRY-A EUROPEAN JOURNAL

Expansion of chemical space for natural products by uncommon P450 reactions

(2017) Xingwang Zhang et al.   NATURAL PRODUCT REPORTS

PLETHORA transcription factors orchestrate de novo organ patterning duringArabidopsislateral root outgrowth

(2017) Yujuan Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biocatalytic Phosphorylations of Metabolites: Past, Present, and Future

(2017) Roland Wohlgemuth et al.   TRENDS IN BIOTECHNOLOGY

Control of stereoselectivity of benzylic hydroxylation catalysed by wild-type cytochrome P450BM3 using decoy molecules

(2017) Kazuto Suzuki et al.   Catalysis Science & Technology

Improved oxidation of aromatic and aliphatic hydrocarbons using rate enhancing variants of P450Bm3 in combination with decoy molecules

(2016) Samuel D. Munday et al.   CHEMICAL COMMUNICATIONS

Design and engineering of artificial oxygen-activating metalloenzymes

(2016) Flavia Nastri et al.   CHEMICAL SOCIETY REVIEWS

Engineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis -β-Methylstyrenes

(2016) Chun Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation inCorynebacterium glutamicum

(2016) Lei Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improving the Monooxygenase Activity and the Regio- and Stereoselectivity of Terpenoid Hydroxylation Using Ester Directing Groups

(2016) Emma A. Hall et al.   ACS Catalysis

A substrate-binding-state mimic of H2O2-dependent cytochrome P450 produced by one-point mutagenesis and peroxygenation of non-native substrates

(2016) Osami Shoji et al.   Catalysis Science & Technology

The Use of Directing Groups Enables the Selective and Efficient Biocatalytic Oxidation of Unactivated Adamantyl C-H Bonds

(2016) Md. Raihan Sarkar et al.   ChemistrySelect

Acetate anion-triggered peroxygenation of non-native substrates by wild-type cytochrome P450s

(2015) Hiroki Onoda et al.   DALTON TRANSACTIONS

Enzymatic hydroxylation of an unactivated methylene C–H bond guided by molecular dynamics simulations

(2015) Alison R. H. Narayan et al.   Nature Chemistry

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis

(2014) Vanja Polic et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The taming of oxygen: biocatalytic oxyfunctionalisations

(2014) Dirk Holtmann et al.   CHEMICAL COMMUNICATIONS

Expanding P450 catalytic reaction space through evolution and engineering

(2014) John A McIntosh et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Bringing out the Potential of Wild-type Cytochrome P450s using Decoy Molecules: Oxygenation of Nonnative Substrates by Bacterial Cytochrome P450s

(2014) Osami Shoji et al.   ISRAEL JOURNAL OF CHEMISTRY

Peroxygenase reactions catalyzed by cytochromes P450

(2014) Osami Shoji et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond Oxygenation

(2014) Solymar Negretti et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of Wild-Type Cytochrome P450BM3 by the Next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence

(2014) Zhiqi Cong et al.   ACS Catalysis

Highly Selective Hydroxylation of Benzene to Phenol by Wild-type Cytochrome P450BM3 Assisted by Decoy Molecules

(2013) Osami Shoji et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Corrigendum: Tuning a P450 Enzyme for Methane Oxidation

(2013) Felipe E. Zilly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Basis of Substrate Conversion in a New Aromatic Peroxygenase

(2013) Klaus Piontek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct hydroxylation of primary carbons in small alkanes by wild-type cytochrome P450BM3 containing perfluorocarboxylic acids as decoy molecules

(2013) Norifumi Kawakami et al.   Chemical Science

Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1

(2012) Amélie Ménard et al.   CHEMBIOCHEM

Chiral-Substrate-Assisted Stereoselective Epoxidation Catalyzed by H2O2-Dependent Cytochrome P450SPα

(2012) Takashi Fujishiro et al.   Chemistry-An Asian Journal

Tuning P450 Enzymes as Oxidation Catalysts

(2012) Rudi Fasan   ACS Catalysis

Use of Perfluorocarboxylic Acids To Trick Cytochrome P450BM3 into Initiating the Hydroxylation of Gaseous Alkanes

(2011) Norifumi Kawakami et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tuning a P450 Enzyme for Methane Oxidation

(2011) Felipe E. Zilly et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

P450BM3(CYP102A1): connecting the dots

(2011) Christopher J. C. Whitehouse et al.   CHEMICAL SOCIETY REVIEWS

Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4

(2011) Aaron T. Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis

(2011) Wei-Cheng Huang et al.   Metallomics

Construction of biocatalysts using the myoglobin scaffold for the synthesis of indigo from indole

(2011) Jiakun Xu et al.   Catalysis Science & Technology

Aromatic C–H bond hydroxylation by P450 peroxygenases: a facile colorimetric assay for monooxygenation activities of enzymes based on Russig’s blue formation

(2010) Osami Shoji et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Understanding substrate misrecognition of hydrogen peroxide dependent cytochrome P450 from Bacillus subtilis

(2010) Osami Shoji et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Modification of the heme active site to increase the peroxidase activity of thermophilic cytochrome P450: A rational approach

(2010) Rabindra Kumar Behera et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

(2010) J. Rittle et al.   SCIENCE

Non-covalent modification of the active site of cytochrome P450 for inverting the stereoselectivity of monooxygenation

(2010) Takashi Fujishiro et al.   TETRAHEDRON LETTERS

Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

(2009) Paul R. Ortiz de Montellano   CHEMICAL REVIEWS

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC fromStreptomyces venezuelae

(2009) Shengying Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

(2009) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA