Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer’s Disease

Age- and Sex-Associated Glucose Metabolism Decline in a Mouse Model of Alzheimer’s Disease

(2022) Camila Gherardelli et al.   JOURNAL OF ALZHEIMERS DISEASE

The role of GSK3 in metabolic pathway perturbations in cancer

(2021) David Papadopoli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oral Glucose Tolerance Test Predicts Episodic Memory Decline: A 10-Year Population-Based Follow-up Study

(2021) Sini Toppala et al.   DIABETES CARE

Lithium increases mitochondrial respiration in iPSC-derived neural precursor cells from lithium responders

(2021) Jordi Requena Osete et al.   MOLECULAR PSYCHIATRY

Lithium: A therapeutic option in Alzheimer’s disease and its prodromal stages?

(2021) Robert Haussmann et al.   NEUROSCIENCE LETTERS

Lithium chloride inhibits phosphorylation of tau protein

(2021) Rei Asano et al.   Alzheimers & Dementia

Disruption of Glucose Metabolism in Aged Octodon degus: A Sporadic Model of Alzheimer's Disease

(2021) Pedro Cisternas et al.   Frontiers in Integrative Neuroscience

High Dosage Lithium Treatment Induces DNA Damage and p57Kip2 Decrease

(2020) Emanuela Stampone et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Andrographolide restores glucose uptake in rat hippocampal neurons

(2020) Camila Gherardelli et al.   JOURNAL OF NEUROCHEMISTRY

Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer’s Disease

(2019) Pedro Cisternas et al.   Frontiers in Cellular Neuroscience

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Canonical Wnt Signaling Modulates the Expression of Pre- and Postsynaptic Components in Different Temporal Patterns

(2019) Milka Martinez et al.   MOLECULAR NEUROBIOLOGY

2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

(2019) B. Pajak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NP03, a Microdose Lithium Formulation, Blunts Early Amyloid Post-Plaque Neuropathology in McGill-R-Thy1-APP Alzheimer-Like Transgenic Rats

(2019) Edward N. Wilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Wnt3a ligand facilitates autophagy in hippocampal neurons by modulating a novel GSK-3β-AMPK axis

(2018) Juvenal A. Ríos et al.   Cell Communication and Signaling

Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer's disease in J20-APP transgenic and wild-type mice

(2018) Cheril Tapia-Rojas et al.   JOURNAL OF NEUROCHEMISTRY

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

(2018) Brian A Gordon et al.   LANCET NEUROLOGY

Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

(2018) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens

(2017) Shiping Bai et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Effect of Lithium on the Mechanism of Glucose Transport in Skeletal Muscles

(2017) Suryun JUNG et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of Wnt/β-catenin signaling by lithium chloride attenuates d -galactose-induced neurodegeneration in the auditory cortex of a rat model of aging

(2017) Ming-Yu Xia et al.   FEBS Open Bio

Cannabidiol attenuates OGD/R-induced damage by enhancing mitochondrial bioenergetics and modulating glucose metabolism via pentose-phosphate pathway in hippocampal neurons

(2017) Shanshan Sun et al.   Redox Biology

How Native and Alien Metal Cations Bind ATP: Implications for Lithium as a Therapeutic Agent

(2017) Todor Dudev et al.   Scientific Reports

Blood-Brain Glucose Transfer in Alzheimer’s disease: Effect of GLP-1 Analog Treatment

(2017) Michael Gejl et al.   Scientific Reports

Alzheimer’s disease: experimental models and reality

(2016) Eleanor Drummond et al.   ACTA NEUROPATHOLOGICA

A Molecular Model for Lithium’s Bioactive Form

(2016) Katharine T. Briggs et al.   BIOPHYSICAL JOURNAL

Increased Glucose Transport into Neurons Rescues Aβ Toxicity in Drosophila

(2016) Teresa Niccoli et al.   CURRENT BIOLOGY

Glucose Transporters in Brain: In Health and in Alzheimer’s Disease

(2016) Leszek Szablewski   JOURNAL OF ALZHEIMERS DISEASE

Toxicity of lithium on isolated heart mitochondria and cardiomyocyte: A justification for its cardiotoxic adverse effect

(2016) Ahmad Salimi et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis

(2016) Pedro Cisternas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

Andrographolide activates the canonical Wnt signalling pathway by a mechanism that implicates the non-ATP competitive inhibition of GSK-3β: autoregulation of GSK-3βin vivo

(2015) Cheril Tapia-Rojas et al.   BIOCHEMICAL JOURNAL

Lithium protects dopaminergic cells from rotenone toxicity via autophagy enhancement

(2015) Lingling Hou et al.   BMC NEUROSCIENCE

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

(2015) Jerome Mertens et al.   NATURE

GLUT1 reductions exacerbate Alzheimer's disease vasculo-neuronal dysfunction and degeneration

(2015) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Long-Term Lithium Treatment Reduces Glucose Metabolism in the Cerebellum and Hippocampus of Nondemented Older Adults: An [18F]FDG-PET Study

(2014) Orestes V. Forlenza et al.   ACS Chemical Neuroscience

Neuroprotective Effects of Lithium: Implications for the Treatment of Alzheimer’s Disease and Related Neurodegenerative Disorders

(2014) O. V. Forlenza et al.   ACS Chemical Neuroscience

A Longitudinal FDG-PET Study of Transgenic Mice Overexpressing GSK- 3β in the Brain

(2014) Javier Cristobal et al.   Current Alzheimer Research

The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism

(2014) Pedro Cisternas et al.   JOURNAL OF NEUROCHEMISTRY

Potential Mechanisms of Action of Lithium in Bipolar Disorder

(2013) Gin S. Malhi et al.   CNS DRUGS

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: Implications for diagnostic and therapeutic strategies

(2013) Zhichun Chen et al.   PROGRESS IN NEUROBIOLOGY

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

The Genetics of Alzheimer Disease

(2013) R. E. Tanzi   Cold Spring Harbor Perspectives in Medicine

Generative FDG-PET and MRI Model of Aging and Disease Progression in Alzheimer's Disease

(2013) Juergen Dukart et al.   PLoS Computational Biology

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease–associated Aβ oligomers

(2012) Theresa R. Bomfim et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term oral lithium treatment attenuates motor disturbance in tauopathy model mice: Implications of autophagy promotion

(2012) Kohei Shimada et al.   NEUROBIOLOGY OF DISEASE

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism

(2012) X. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder

(2012) Alexander J. Valvezan et al.   Frontiers in Molecular Neuroscience

Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial

(2011) Orestes V. Forlenza et al.   BRITISH JOURNAL OF PSYCHIATRY

Temporal changes in mRNA expression of the brain nutrient transporters in the lithium–pilocarpine model of epilepsy in the immature and adult rat

(2011) Claire Leroy et al.   NEUROBIOLOGY OF DISEASE

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

(2011) De-Maw Chuang et al.   Frontiers in Molecular Neuroscience

CSF Biomarkers in Prediction of Cerebral and Clinical Change in Mild Cognitive Impairment and Alzheimer's Disease

(2010) A. M. Fjell et al.   JOURNAL OF NEUROSCIENCE

Wnt-5a occludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

(2010) Waldo Cerpa et al.   Molecular Neurodegeneration

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

The history of lithium therapy

(2009) Edward Shorter   BIPOLAR DISORDERS

Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue

(2009) Iris C Maurer et al.   BIPOLAR DISORDERS

FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer’s disease

(2009) Lisa Mosconi et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Lithium Trial in Alzheimer's Disease

(2009) Harald Hampel et al.   JOURNAL OF CLINICAL PSYCHIATRY

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1ΔE9 mouse model of Alzheimer's disease

(2009) E M Toledo et al.   MOLECULAR PSYCHIATRY

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Wnt/ -catenin signaling is required for CNS, but not non-CNS, angiogenesis

(2009) R. Daneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GSK3: a multifaceted kinase in Wnt signaling

(2009) Dianqing Wu et al.   TRENDS IN BIOCHEMICAL SCIENCES

Regulation of glycolysis and pentose–phosphate pathway by nitric oxide: Impact on neuronal survival

(2008) Juan P. Bolaños et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

A feasibility and tolerability study of lithium in Alzheimer's disease

(2008) Alastair Macdonald et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The role of Wnt signaling in neuronal dysfunction in Alzheimer's Disease

(2008) Nibaldo C Inestrosa et al.   Molecular Neurodegeneration

FDG-PET Study in Pathological Gamblers

(2008) Eric Hollander et al.   NEUROPSYCHOBIOLOGY

Roles of insulin signalling and p38 MAPK in the activation by lithium of glucose transport in insulin-resistant rat skeletal muscle

(2008) Antoni R. Macko et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

Hippocampal hypometabolism predicts cognitive decline from normal aging

(2007) Lisa Mosconi et al.   NEUROBIOLOGY OF AGING