The Complement System, Aging, and Aging-Related Diseases

Involvement of complement peptides C3a and C5a in osteoarthritis pathology

(2022) Nicole Schäfer et al.   PEPTIDES

The complement system in age-related macular degeneration

(2021) Angela Armento et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial C3a Receptor Activation in Oxidatively Stressed Epithelial Cells Reduces Mitochondrial Respiration and Metabolism

(2021) Masaaki Ishii et al.   Frontiers in Immunology

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

(2021) Jasna Friščić et al.   IMMUNITY

Inhibition of the Wnt/β‑catenin signaling pathway reduces autophagy levels in complement treated podocytes

(2021) Zhaocheng Dong et al.   Experimental and Therapeutic Medicine

Saponins isolated from Radix polygalae extent lifespan by modulating complement C3 and gut microbiota

(2021) Wu Zeng et al.   PHARMACOLOGICAL RESEARCH

Complement C4, Infections, and Autoimmune Diseases

(2021) Hongbin Wang et al.   Frontiers in Immunology

Complement System in Alzheimer’s Disease

(2021) Akash Shah et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Centenarian longevity is positively correlated with IgE levels but negatively correlated with C3/C4 levels, abdominal obesity and metabolic syndrome

(2020) Shihui Fu et al.   Cellular & Molecular Immunology

Complement-Mediated Events in Alzheimer’s Disease: Mechanisms and Potential Therapeutic Targets

(2020) Andrea J. Tenner   JOURNAL OF IMMUNOLOGY

Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation

(2020) Thore Hettmann et al.   Scientific Reports

Preclinical Pharmacokinetics of Complement C5a Receptor Antagonists PMX53 and PMX205 in Mice

(2020) Vinod Kumar et al.   ACS Omega

Aging Fits the Disease Criteria of the International Classification of Diseases

(2020) Khaltourina Daria et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Modelling biological age based on plasma peptides in Han Chinese adults

(2020) Weijie Cao et al.   Aging-US

Complement component 3 prevents imiquimod-induced psoriatic skin inflammation by inhibiting apoptosis in mice

(2020) Quan-you Zheng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Associations Between Complement Components and Vitamin D and the Physical Activities of Daily Living Among a Longevous Population in Hainan, China

(2020) Chi Zhang et al.   Frontiers in Immunology

Complement inhibition as a therapeutic strategy in retinal disorders

(2019) Enoch Kassa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Senescent cells in the development of cardiometabolic disease

(2019) Andrea C. Postmus et al.   CURRENT OPINION IN LIPIDOLOGY

­­­Intracellular cytosolic complement component C3 regulates cytoprotective autophagy in pancreatic beta cells by interaction with ATG16L1

(2019) Ben C. King et al.   Autophagy

Complement component C5a induces aberrant epigenetic modifications in renal tubular epithelial cells accelerating senescence by Wnt4/βcatenin signaling after ischemia/reperfusion injury

(2019) Giuseppe Castellano et al.   Aging-US

Body composition changes in diabetes and aging

(2019) Mohammed E. Al-Sofiani et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Hallmarks of senescence and aging

(2019) Slavica Dodig et al.   Biochemia Medica

Ageing as a risk factor for neurodegenerative disease

(2019) Yujun Hou et al.   Nature Reviews Neurology

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Complement C5a Induces Renal Injury in Diabetic Kidney Disease by Disrupting Mitochondrial Metabolic Agility

(2019) Sih Min Tan et al.   DIABETES

High complement levels in astrocyte-derived exosomes of Alzheimer disease

(2018) Edward J. Goetzl et al.   ANNALS OF NEUROLOGY

Resistance training prevents muscle fibrosis and atrophy via down-regulation of C1q-induced Wnt signaling in senescent mice

(2018) Naoki Horii et al.   FASEB JOURNAL

The Impact of Aging on Cardio and Cerebrovascular Diseases

(2018) Carmine Izzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role and mechanism of ROS scavengers in alleviating NLRP3-mediated inflammation

(2018) Takami Sho et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Protective Role of Complement C3 Against Cytokine-Mediated β-Cell Apoptosis

(2017) Reinaldo S Dos Santos et al.   ENDOCRINOLOGY

A review of human diseases caused or exacerbated by aberrant complement activation

(2017) Patrick L. McGeer et al.   NEUROBIOLOGY OF AGING

Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a

(2017) Rink-Jan Lohman et al.   Nature Communications

Obesity and related consequences to ageing

(2016) Magdalena Jura et al.   AGE

Increased choroidal mast cells and their degranulation in age-related macular degeneration

(2016) Imran A Bhutto et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

(2016) Pierpaola Davalli et al.   Oxidative Medicine and Cellular Longevity

C5a and pain development: An old molecule, a new target

(2016) Andreza U. Quadros et al.   PHARMACOLOGICAL RESEARCH

The effect of complement C5a on mitochondrial functions of PC12 cells

(2016) Ryan D. Martinus et al.   NEUROREPORT

The role of complement factor C3 in lipid metabolism

(2015) Andreea Barbu et al.   MOLECULAR IMMUNOLOGY

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System Part I – Molecular Mechanisms of Activation and Regulation

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

Complement System in Lung Disease

(2014) Pankita H. Pandya et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The complement system in human cardiometabolic disease

(2014) E. Hertle et al.   MOLECULAR IMMUNOLOGY

Aberrant Activation of the WNT/β-Catenin Signaling Pathway in Lupus Nephritis

(2014) Xiao-dong Wang et al.   PLoS One

Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular Degeneration

(2013) Jaimie Hoh Kam et al.   AMERICAN JOURNAL OF PATHOLOGY

C3a modulates IL-1  secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

(2013) E. Asgari et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitochondria and the Lectin Pathway of Complement

(2013) Christel R. Brinkmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Pathogenesis of Lupus Nephritis

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement C3 and its polymorphism: biological and clinical consequences

(2013) Joris R. Delanghe et al.   PATHOLOGY

The receptor for complement component C3a mediates protection from intestinal ischemia-reperfusion injuries by inhibiting neutrophil mobilization

(2013) Mike C. L. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

(2012) Atsuhiko T. Naito et al.   CELL

Pros and cons for C4d as a biomarker

(2012) Danielle Cohen et al.   KIDNEY INTERNATIONAL

Complement C3 and cleavage products in cardiometabolic risk

(2011) Altan Onat et al.   CLINICA CHIMICA ACTA

Histological and Direct Evidence for the Role of Complement in the Neuroinflammation of AD

(2011) Robert Veerhuis   Current Alzheimer Research

Age-related macular degeneration and the complement system

(2011) S. Khandhadia et al.   IMMUNOBIOLOGY

Complement mediated apoptosis leads to the loss of retinal ganglion cells in animal model of glaucoma

(2011) Purushottam Jha et al.   MOLECULAR IMMUNOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Apoptosis and aging: increased resistance to apoptosis enhances the aging process

(2010) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-κB-dependent blockade

(2009) Gil Amarilyo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population

(2009) Altan Onat et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Nociceptive sensitization by complement C5a and C3a in mouse

(2009) Jun Ho Jang et al.   PAIN

Developments in the clinical understanding of osteoarthritis

(2009) David T Felson   ARTHRITIS RESEARCH & THERAPY